A5075776102- Dialysis and Renal Disease Management
- Pediatric Urology and Nephrology Studies
- Renal Diseases and Glomerulopathies
- Central Venous Catheters and Hemodialysis
- Parathyroid Disorders and Treatments
- Adolescent and Pediatric Healthcare
- Bone health and treatments
- Coenzyme Q10 studies and effects
- Hemoglobinopathies and Related Disorders
- Genetic Syndromes and Imprinting
- Hemodynamic Monitoring and Therapy
- Acute Kidney Injury Research
- Muscle and Compartmental Disorders
- Urinary Tract Infections Management
- Genomics and Rare Diseases
- Inflammatory Myopathies and Dermatomyositis
- Childhood Cancer Survivors' Quality of Life
- Biomedical Research and Pathophysiology
- Genetic and Kidney Cyst Diseases
- Dermatological and Skeletal Disorders
- Ion Transport and Channel Regulation
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Neonatal Health and Biochemistry
- ATP Synthase and ATPases Research
- Blood Pressure and Hypertension Studies
Ajou University
2024-2025
Seoul National University Children's Hospital
2018-2024
Seoul National University
2019-2024
Ministry of Health and Welfare
2020-2022
Seoul National University Hospital
2017
The outbreak of Coronavirus Disease 2019 (COVID-19) caused a worldwide pandemic.Less than 6 weeks after the first confirmed cases in Korea, patient number exceeded 5,000, which overcrowded limited hospital resources and forced patients to stay at home.To allocate medical efficiently, Korea implemented novel institution for purpose treating with cohort isolation out hospital, namely Community Treatment Center (CTC).Herein, we report results initial management one largest CTC Korea.A total 309...
Abstract Background The purpose of this study was to examine the prevalence hypertension in Korean adolescents, its long-term trends, and factors associated with development hypertension. Methods Data Korea National Health Nutrition Examination Survey (KNHANES) from 2007 2020 were combined into three time periods (2007–2011, 2012–2016, 2017–2020). A total 11,146 adolescents aged 10–18 included analysis. definition based on 2017 American Academy Pediatrics guidelines for Results age-adjusted...
Abstract Background Coenzyme Q10 (CoQ10) nephropathy is a well-known cause of hereditary steroid-resistant nephrotic syndrome, primarily impacting podocytes. This study aimed to elucidate variations in individual cell-level gene expression CoQ10 using single-cell transcriptomics. Methods We conducted sequencing kidney biopsy specimen from 5-year-old boy diagnosed with caused by compound heterozygous COQ2 mutation complicated immune complex-mediated glomerulonephritis. The analysis focused on...
BackgroundDue to the limited availability of therapeutic agents for type 2 diabetic kidney disease (T2DKD), there is a need further knowledge derived from experimental models and innovative techniques. In addressing this issue, single-cell RNA sequencing (scRNA-seq) has been exclusively applied genetically modified model, but not an induced model representing T2DKD. Herein, we analyzed scRNA-seq other experiments T2DKD validated results in human-derived biospecimens. MethodsThe was by...
Abstract Background Acute kidney injury (AKI) is a critical issue in cancer patients because it not only morbid complication but also able to interrupt timely diagnostic evaluation or planned optimal treatment. However, the impact of AKI on overall mortality remains unclear. Methods We conducted retrospective cohort study 67 986 patients, from 2004 2013 evaluate relationship between and all‐cause mortality. used KDIGO definition grading system. Results During 3.9 ± 3.1 years follow‐up, 33.8%...
Dapagliflozin, a sodium-glucose cotransporter-2 inhibitor, has shown results in slowing estimated glomerular filtration rate (eGFR) decline and reducing proteinuria adult patients with chronic kidney disease. This retrospective study examines dapagliflozin's effects 22 children disease proteinuria.
Multicentric carpotarsal osteolysis syndrome (MCTO) is characterized by progressive destruction and disappearance of the carpal tarsal bones associated with nephropathy. MCTO caused loss-of-function mutations in MAF bZIP transcription factor B (MAFB) gene. This report describes three unrelated patients MAFB mutations, including two male one female patient. Osteolytic lesions were detected at 2 years, 12 14 months age, respectively. Associated proteinuria was noted 4 3 Kidney biopsy performed...
Background: X-linked hypophosphatemia (XLH) is the most frequent form of hypophosphatemic rickets and caused by mutations in PHEX gene. We analyzed genotype-phenotype correlations XLH patients with proven mutations. Methods: were detected 55 out 81 who clinically presented rickets. The grouped into nontruncating ( n = 9) truncating 46) mutation groups; their initial presentation as well long-term clinical findings evaluated according to these groups. Results: Initial findings, including...
Bioimpedance spectroscopy (BIS) is a noninvasive method used to evaluate body fluid volume status in dialysis patients, but reports on its effectiveness pediatrics are scarce. We investigated the correlation between BIS and clinical characteristics identified changes patients whose prescription was modified based BIS. The medical records of children maintenance who had undergone 2017 2019 were reviewed. Of 49 14 overhydrated, >15% proportion overhydration relative extracellular water...
Peritonitis is the most common complication of peritoneal dialysis (PD). This study aimed to investigate changes in incidence, risk factors, microbiology, and clinical outcomes PD-associated peritonitis past decades.
<title>Abstract</title> <bold>Background</bold> Coenzyme Q10 (CoQ10) nephropathy is a well-known cause of hereditary steroid-resistant nephrotic syndrome, primarily impacting podocytes. This study aimed to elucidate variations in individual cell-level gene expression CoQ10 using single-cell transcriptomics. <bold>Methods</bold> We conducted sequencing kidney biopsy specimen from 5-year-old boy diagnosed with caused by compound heterozygous <italic>COQ2</italic> mutation. The analysis focused...
Severe hypercalcemia is rarely encountered in children, even though serum calcium concentrations above 15-16 mg/dL could be life-threatening. We present a patient having severe and azotemia. A 14-year-old boy with no significant past medical history was referred to our hospital Laboratory imaging studies excluded hyperparathyroidism solid tumor. Other laboratory findings including peripheral blood profile were unremarkable. His not improved massive hydration, diuretics, or hemodialysis, but...
Purpose: This article was to investigate the association between urinary tract infections (UTIs) and high weight status in infancy.Methods: We conducted a nationwide matched cohort study from January 2018 December 2020 using data Korean National Health Insurance System Screening Program for Infants Children. analyzed UTI diagnosis codes (which defined as being 90th percentile or higher of weight-for-age).Results: found that 22.8% infants with UTIs exhibited status, compared 20.0% non-UTI...
Abstract Background : Most patients with chronic kidney disease develop variable degrees of secondary hyperparathyroidism, which is resolved after transplantation (KT). However, persistent hyperparathyroidism KT in adults reported to occur 50% undergoing KT; this has not been investigated thoroughly children. Here, we analyzed the prevalence and its risk factors among children a single-referral hospital. Methods This retrospective observational study medical records who underwent between...
Abstract Background Peritonitis is the most common complication of peritoneal dialysis (PD). This study aimed to investigate changes in incidence, risk factors, microbiology, and clinical outcomes PD-associated peritonitis past decades. Methods was a retrospective that included children who initiated chronic PD at Seoul National University Children’s Hospital between 2000 2017. The patients were divided into two groups according year initiation: those 2008 2009 follow-up data until...
Although various childhood illnesses are known to influence growth status, the impact of urinary tract infections (UTI) on subsequent remains unclear. This study was conducted examine association between UTI during infancy and status at 30-36 months.Nationwide population-based matched cohort done using data from Korean National Health Insurance System (NHIS) Screening Program for Infants Children (NHSPIC) January 2018 December 2020. Height weight standard deviation scores (SDSs) fourth...