A5081167839- Immune Cell Function and Interaction
- Sinusitis and nasal conditions
- T-cell and B-cell Immunology
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Olfactory and Sensory Function Studies
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Obstructive Sleep Apnea Research
- Immunotherapy and Immune Responses
- Long-Term Effects of COVID-19
- Neuroscience of respiration and sleep
- Head and Neck Surgical Oncology
- IL-33, ST2, and ILC Pathways
- Biochemical Analysis and Sensing Techniques
- Tracheal and airway disorders
- Cytomegalovirus and herpesvirus research
- Advanced Chemical Sensor Technologies
- Facial Nerve Paralysis Treatment and Research
- S100 Proteins and Annexins
- Renal Transplantation Outcomes and Treatments
- Immune Response and Inflammation
- Ear Surgery and Otitis Media
- Respiratory viral infections research
- Oral and Maxillofacial Pathology
Yonsei University
2014-2025
Yonsei University Health System
2024
Severance Hospital
2022-2024
Korea Advanced Institute of Science and Technology
2019-2023
Memory T cells contribute to rapid viral clearance during re-infection, but the longevity and differentiation of SARS-CoV-2-specific memory remain unclear. Here we conduct ex vivo assays evaluate CD4+ CD8+ cell responses in COVID-19 convalescent patients up 317 days post-symptom onset (DPSO), find that are maintained study period regardless severity COVID-19. In particular, observe sustained polyfunctionality proliferation capacity cells. Among detected by activation-induced markers,...
Abstract Invariant natural killer T (iNKT), mucosal-associated invariant (MAIT), and γδ cells are innate that acquire memory phenotype in the thymus share similar biological characteristics. However, how their effector differentiation is developmentally regulated still unclear. Here, we identify analogous subsets of these three cell types transcriptional profiles. Using single-cell RNA sequencing, show iNKT, MAIT mature via shared, branched rather than linear maturation or TCR-mediated...
Subsets of the human CD8+ T cell population express inhibitory NK receptors, such as killer immunoglobulin-like receptors (KIRs) and NKG2A. In present study, we examine phenotypic functional characteristics KIR+CD8+ cells NKG2A+CD8+ cells. KIRs NKG2A tend to be expressed by in a mutually exclusive manner. addition, TCR clonotypes barely overlap with those cells, are more terminally differentiated replicative senescent than Among cytokine IL12Rβ1, IL12Rβ2, IL18Rβ highly whereas IL2Rβ is...
Background and Objectives: Pediatric chronic rhinosinusitis (CRS) significantly affects children’s quality of life learning abilities. This study aimed to evaluate the postoperative outcomes in pediatric patients who underwent functional endoscopic sinus surgery (FESS) for CRS.Methods: A retrospective review was conducted on FESS CRS at 11 university hospitals. The inclusion criteria were under 20 years old with bilateral disease operated between January 2005 December 2021. data collected...
The liver provides a unique niche of lymphocytes enriched with large proportion innate-like T cells. However, the heterogeneity and functional characteristics hepatic T-cell population remain to be fully elucidated.We obtained sinusoidal mononuclear cells from perfusate healthy donors recipients HBV-associated chronic disease (CLD) during transplantation. We performed CITE-seq analysis CD45+ in combination cell receptor (TCR)-seq flow cytometry examine phenotypes functions CD8+ cells.We...
Regulatory T (Treg) cells are important in preventing acute rejection (AR) solid organ transplantation, but the clinical relevance of different kinetics early after liver transplantation (LT) rejectors and non-rejectors is unclear. We analyzed peripheral blood samples 128 LT recipients receiving basiliximab induction plus tacrolimus immunosuppression. Samples were obtained at pretransplant, D7, D30 LT. Frequency phenotype Tregs by flow cytometry. The predictive value Treg frequency D7 was...
Calprotectin is an antimicrobial peptide primarily secreted by neutrophils. Furthermore, calprotectin secretion increases in patients with chronic rhinosinusitis (CRS) polyps (CRSwNP) and positively correlates neutrophil markers. However, CRSwNP known to be associated type 2 inflammation related tissue eosinophilia. Therefore, the authors investigated expression eosinophils eosinophil extracellular traps (EETs) explored associations between clinical findings of CRS.A total 63 participated,...
Abstract Background Chronic inflammation triggers tissue remodeling in human nasal epithelial (HNE) cells. S100A9, a protein secreted by inflammatory cells, exhibits potent proinflammatory activity. However, its effect on HNE cell remodeling, such as squamous metaplasia, remains unclear. Therefore, this study aimed to determine the effects and underlying pathways of S100A9 investigate clinical implications chronic rhinosinusitis (CRS). Methods Cultured cells were treated with S100A9. Bulk...
The olfactory epithelium (OE) and bulb (OB) are the major components of system play critical roles in perception. However, embryonic development OE OB by using specific genes has not been comprehensively investigated yet. Most previous studies were limited to a stage, very little is known, till date, about OE.The current study aimed explore mouse spatiotemporal analysis histological features from prenatal postnatal period.We found that divided into endo-turbinate, ecto-turbinate, vomeronasal...
Respiratory viral infection increases host susceptibility to secondary bacterial infections, yet the precise dynamics within airway epithelia remain elusive. Here, we elucidate pivotal role of CD47 in epithelium during super-infection. We demonstrated that upon influenza virus infection, expression was upregulated and localized on apical surface ciliated cells primary human nasal or bronchial epithelial cells. This induced exposure provided attachment sites for Staphylococcus aureus, thereby...