A5039841219- Nuclear Physics and Applications
- Nuclear reactor physics and engineering
- Alzheimer's disease research and treatments
- Cancer Immunotherapy and Biomarkers
- Nuclear Materials and Properties
- Bioinformatics and Genomic Networks
- Ubiquitin and proteasome pathways
- Graphite, nuclear technology, radiation studies
- Immune cells in cancer
- Axon Guidance and Neuronal Signaling
- Immunotherapy and Immune Responses
- Genetic Associations and Epidemiology
- Atomic and Subatomic Physics Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Nanoplatforms for cancer theranostics
- Inorganic Fluorides and Related Compounds
- ATP Synthase and ATPases Research
- Phagocytosis and Immune Regulation
- Nuclear physics research studies
- Nuclear and radioactivity studies
- Quantum, superfluid, helium dynamics
- Astronomical and nuclear sciences
- Renin-Angiotensin System Studies
- Adrenal and Paraganglionic Tumors
- 14-3-3 protein interactions
Icahn School of Medicine at Mount Sinai
2018-2024
University of Notre Dame
2020-2023
Nia Association
2022
ID Genomics (United States)
2022
Inserm
2015
Centre National de la Recherche Scientifique
2015
Harvard University
2014
University of Basel
1977
Monsanto (United States)
1968-1972
Mound Laser & Photonics Center (United States)
1969
Abstract Alzheimer’s disease (AD) affects half the US population over age of 85 and is universally fatal following an average course 10 years progressive cognitive disability. Genetic genome-wide association studies (GWAS) have identified about 33 risk factor genes for common, late-onset AD (LOAD), but these loci fail to account majority affected cases can neither provide clinically meaningful prediction development nor offer actionable mechanisms. This cohort study generated large-scale...
Three major molecular subtypes of Alzheimer’s disease are identified, cross-validated, and characterized across 1543 individuals.
Metabolites, the biochemical products of cellular process, can be used to measure alterations in pathways related pathogenesis Alzheimer's disease (AD). However, relationships between systemic abnormalities metabolism and AD are poorly understood. In this study, we aim identify AD-specific metabolomic changes their potential upstream genetic transcriptional regulators through an integrative systems biology framework for analyzing genetic, transcriptomic, metabolomic, proteomic data AD....
More than 130,000 people have strokes each year in the United States [1]. Of these victims, 76% are left with disabilities that cost nation over $54 billion lost work and medical fees. One prominent disability is upper extremity hemiplegia, which occurs among approximately 50% of stroke sufferers [2]. Robotic technology has potential to provide an automated platform for controled rehabilitation assisted, task-oriented therapy.Several systems been designed assist patient articulation impaired...
Primary aldosteronism is one of the leading causes secondary hypertension, causing significant morbidity and mortality. A number genetic defects have recently been identified in primary aldosteronism, whereas we mutations ARMC5, a tumor-suppressor gene, cortisol-producing macronodular adrenal hyperplasia.We investigated cohort 56 patients who were referred to National Institutes Health for evaluation ARMC5 defects.Patients underwent step-wise diagnosis, with measurement serum aldosterone...
Chemotherapy prior to immune checkpoint blockade (ICB) treatment appears improve ICB efficacy but resistance remains a clinical challenge and is attributed highly plastic myeloid cells associating with the tumor microenvironment (TIME). Here we show by CITE-seq single-cell transcriptomic trajectory analyses that neoadjuvant low-dose metronomic chemotherapy (MCT) leads characteristic co-evolution of divergent cell subsets in female triple-negative breast cancer (TNBC). Specifically, identify...
Gold nanoparticles (AuNPs) have been shown to enhance cancer radiotherapy (RT) gain by localizing the absorption of radiation energy in tumor while sparing surrounding normal tissue from toxicity. Previously, we showed that AuNPs enhanced RT induced DNA damage and cytotoxicity MCF7 breast cells. Interestingly, found cells exhibited a size-dependent intracellular localization (4 nm preferentially cytoplasm 14 nucleus). We extended those studies an vivo model examined effects on cytotoxicity,...
A few copy number variations (CNVs) have been reported for Alzheimer's disease (AD). However, there is a lack of systematic investigation CNVs in AD based on whole genome sequencing (WGS) data.We used four methods to identify consensus from the WGS data 1,411 individuals and further investigated their functional roles using matched transcriptomic clinicopathological identified 3,012 rare AD-specific whose residing genes are enriched cellular glucuronidation neuron projection pathways. Genes...
Lateral epicondylitis is a commonly made diagnosis for general practitioners and orthopedic surgeons. Corticosteroid injection mainstay of early treatment. However, conflicting evidence exists to support the use steroid injection, no in literature supports an technique. Nineteen patients diagnosed with acute lateral were evaluated compare peppered- single-injection techniques using Disabilities Arm, Shoulder Hand (DASH) score, visual analog score (VAS), grip strength. For elbows single mean...
Neutron emission rates and neutron spectra were determined for two 238Pu power sources: SNAP 27-1, a 1482-W plutonium dioxide source the Apollo Space Program, HP 15-2, 15.84-W metal Artificial Heart Program. The measurements made with single stilbene crystal fast-neutron spectrometer long counter. specific yields (2.2 ± 0.1) × 104 n/sec per gram of 27-1 (3.9 0.2) 103 15-2. Neutrons from these sources are due to spontaneous fission 238Pu, neutron-induced plutonium, (α, n) reactions....
SUMMARY To study the molecular mechanisms driving pathogenesis and identify novel therapeutic targets of late onset Alzheimer’s Disease (LOAD), we performed an integrative network analysis whole-genome DNA RNA sequencing profiling four cortical areas, including parahippocampal gyrus, across 364 donors spanning full spectrum LOAD-related cognitive neuropathological disease severities. Our analyses revealed thousands changes uncovered for first-time multiple neuron specific gene subnetworks...
Despite advancements in treatment, high‐grade serous ovarian cancer (HGSOC) is still characterized by poor patient outcomes. To understand the molecular heterogeneity of this disease, which underlies challenge selecting optimal treatments for HGSOC patients, we have integrated genomic, transcriptomic, and epigenetic information to identify seven new subtypes using a multiscale clustering method. These not only significantly distinct overall survival, but also exhibit unique patterns gene...
<title>Abstract</title> Communication between glial cells has a profound effect on the pathophysiology of Alzheimer’s disease (AD), but underlying mechanisms remain unclear. Here, we reveal role reactive astrocytes in enforcing cell distancing nets surrounding amyloid plaques, which restricts microglial coverage Aβ, prerequisite to detect and engulf deposits. This process is mediated through guidance receptor Plexin-B1, identified as key network regulator late-onset AD. We show that...
Abstract Breast cancer is the most common type of among women worldwide, and it estimated that 294 000 new diagnoses 37 deaths will occur each year in United States alone by 2030. Large-scale genomic studies have identified a number genetic loci with alterations breast cancer. However, identification genes are critical for tumorgenicity still remains challenge. Here, we perform comprehensive functional multi-omics analysis somatic mutations identify previously unknown key regulators...