A5036700493- MicroRNA in disease regulation
- Mycobacterium research and diagnosis
- Cancer-related molecular mechanisms research
- Tuberculosis Research and Epidemiology
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Renal cell carcinoma treatment
- RNA modifications and cancer
- Renal and related cancers
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Bacteriophages and microbial interactions
- Advanced Proteomics Techniques and Applications
- Biosensors and Analytical Detection
- Electrochemical sensors and biosensors
- Cancer therapeutics and mechanisms
- Amino Acid Enzymes and Metabolism
- Bioinformatics and Genomic Networks
- Circular RNAs in diseases
- Immune Response and Inflammation
- Rheumatoid Arthritis Research and Therapies
- Gut microbiota and health
- Inflammatory Bowel Disease
- Infectious Diseases and Mycology
- Antibiotic Resistance in Bacteria
Jinan University
2023
Renji Hospital
2018-2021
Shanghai Jiao Tong University
2018-2020
Second Hospital of Shanxi Medical University
2020
Shanxi Medical University
2020
Southern Medical University
2013-2015
Nanfang Hospital
2013-2015
Guangzhou Chest Hospital
2009-2010
Hunan Normal University
2006
Clear cell renal carcinoma (ccRCC) is a common kidney malignancy characterized by poor prognosis. Suppressor of variegation 3–9 homolog 1 (SUV39H1), which encodes histone H3 lysine 9 methyltransferase, has been reported to act as an oncogene in many cancers. However, it unclear whether SUV39H1 involved ccRCC. Here, we report that expression frequently upregulated ccRCC tumors and significantly correlated with progression. level independent risk factor for cancer prognosis, integration...
Background and Objective: Epigenetic alterations are common events in clear cell renal carcinoma (ccRCC), protein arginine methyltransferase 1 (PRMT1) is an important epigenetic regulator cancers. However, its role ccRCC remains unclear. Methods: We investigated PRMT1 expression level correlations to clinicopathological factors prognosis patients based on tissue microarrays (TMAs). Genetic knockdown pharmacological inhibition using a novel inhibitor DCPT1061 were performed investigate the...
Clear cell renal carcinoma (ccRCC) is the most common kidney malignancy characterized by a poor prognosis. The treatment efficacy of immune checkpoint inhibitors (ICIs) also varies widely in advanced ccRCC. We aim to construct robust gene signature improve prognostic discrimination and prediction ICIs for ccRCC patients. In this study, adopting differentially expressed genes from seven datasets GEO (Gene Expression Omnibus), novel (FOXM1&TOP2A) was constructed TCGA (The Cancer Genome Atlas)...
Hepatocyte nuclear factor-3β (HNF-3β) plays a critical role in hepatocyte differentiation and controls liver-specific gene expression during the development of hepatocellular carcinoma (HCC), but molecular basis this process has not been fully elucidated. microRNAs (miRNAs) are powerful, post-transcriptional regulators expression. Whether miRNAs can impact effects HNF-3β HCC is still unknown. miR-141 levels were detected HepG2 cells, using real-time quantitative RT-PCR (qRT-PCR). Luciferase...
Since glucose biosensors are one of the most popular and widely used point-of-care testing devices, a novel electrochemical enzyme-linked immunosorbent assay (ELISA) for protein biomarkers has been developed based on detection strategy. In this study, α-fetoprotein (AFP) was as target protein. An ELISA system constructed using anti-AFP antibodies immobilized microwell plates capture antibody (Ab1) multi-label bioconjugates signal tracer. The were synthesized by attaching glucoamylase...
MicroRNAs (miRNAs) have been reported to be involved in multiple biological pathways that can influence tumor progression and metastasis. High-risk human papillomavirus (HR-HPVs) is aetiologically correlated cervical cancer. Recently, miRNAs were regulated by virus play pivotal roles HPV-related progression. However, the underlying mechanism remains poorly understood. In present study, we report HPV16 E7 upregulated miR-27b promote proliferation invasion The results showed PPARγ, as a target...
Chromophobe renal cell carcinoma (ChRCC) is the second common subtype of non-clear (nccRCC), which accounting for 4-5% (RCC). However, there no effective bio-marker to predict clinical outcomes this malignant disease. Bioinformatic methods may provide a feasible potential solve problem.In study, differentially expressed genes (DEGs) ChRCC samples on The Cancer Genome Atlas database were filtered out construct co-expression modules by weighted gene network analysis and key module identified...
MicroRNAs (miRNAs) are a group of small endogenous, non-coding RNA molecules that have been demonstrated to be essential regulators many critical biological and pathological processes. Because their high stability in blood the strong implication miRNA expression profiles for human diseases, miRNAs currently emerging as promising circulating biomarkers diagnosis or prognosis variety diseases. The TRIzol-based technique has widely used cell tissue extraction because its economy reliability....
Splenomegaly is a prominent clinical manifestation of malaria and the causes remain incompletely clear. Anemia induced in extramedullary splenic erythropoiesis compensation for loss erythrocytes. However, regulation unknown. An inflammatory response could facilitate settings infection inflammation. Here, when mice were infected with rodent parasites, Plasmodium yoelii NSM, TLR7 expression splenocytes was increased. To explore roles erythropoiesis, we wild-type -/- C57BL/6 P. NSM found that...
Circulating microRNAs (miRNAs) have been confirmed to play an important role in biological processes, such as cell proliferation, differentiation and apoptosis.Founded on the high stability minimal invasiveness, circulating miRNAs could be applied clinical practice biomarkers. There are many technological approaches platforms for detection but without a consistent protocol.Meanwhile, there various factors affecting detection. In this review, technical preanalytical miRNA profiling...
Objective To study the roles of interleukin-15(IL-15)in immunoprotection and tuberculosis progress by detecting serum levels IL-15 percentages effector CD8+ T cells in patients with pulmonary tuberculosis.Methods The 98 were detected,and analyzed according to degrees disease severity sputum smear. Results first-time treatment group re-treatment lower than those control group(P<0.05 or P<0.01).The group(all severe degree medium mild tuberculosis(all P<0.01).However,there no significant...
Objective To identify clinicopathologic features of early onset RCC in Asian population. Methods Surveillance, Epidemiology, End Results Registry (SEER) database were queried for cases diagnosed as Asia or pacific islander between 2010 and 2015. Patients with Renji hospital during 2014—2018 reviewed. All was divided into two group, including group (≤46 years) control (>46 years). There 3 023 patients average age 61 years old, ranging from 10-93 old SEER cohort 2 702 57 15-89...
Background: Rheumatoid arthritis (RA) is a common autoimmune disorder with joint destruction and synovial inflammation characterized by abnormal immune responses to autoantigens. Our previous studies have demonstrated that impaired peripheral lymphocytes especially insufficiency of regulatory T cells (Tregs) played an important role in pathogenesis RA 1 2 . Interestingly, the dysbiosis gut microbiota triggers several types diseases through imbalance lymphocyte subsets 3 However, detailed...