A5100725521- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- RNA modifications and cancer
- Circular RNAs in diseases
- Prostate Cancer Treatment and Research
- Ferroptosis and cancer prognosis
- Prostate Cancer Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Luminescence and Fluorescent Materials
- Peptidase Inhibition and Analysis
- interferon and immune responses
- Nanoplatforms for cancer theranostics
- Urologic and reproductive health conditions
- RNA and protein synthesis mechanisms
- Cancer Research and Treatments
- Protease and Inhibitor Mechanisms
- NF-κB Signaling Pathways
- Cancer Immunotherapy and Biomarkers
- Click Chemistry and Applications
Soochow University
2009-2025
The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)
2024-2025
First Affiliated Hospital of Soochow University
2009-2025
Chronic non-bacterial prostatitis (CNP) is a common urologic disease that linked to the development of prostate cancer. Long non-coding RNA (lncRNA) GAS5 has been identified mediate cell proliferation in cancer, although its role CNP still unclear. Human epithelial line RWPE-1 was induced by lipopolysaccharide (LPS) mimic model vitro. Real-time PCR performed determine expression and COX-2, while western blotting used evaluate protein COX-2. The interaction between COX-2 determined using...
Background: Matrix Metalloproteinases (MMPs) play an indispensable role in the initial alteration and development of PCa. We tried to generate MMP-related prognostic signature (MMPS) prostate cancer (PCa). Methods: TCGA-PRAD, MSKCC/GSE21032, GSE116918, GSE70769 cohorts were enrolled assess value MMPs. The least absolute shrinkage selection operator (LASSO) Cox regression was employed MMPS signature. log-rank test Kaplan-Meier (K-M) survival curve applied show difference RFS, receiver...
Herein, the effect of long noncoding RNA forkhead box D1 antisense 1 (FOXD1-AS1) on malignant phenotypes prostate cancer (PCa) cells was investigated. FOXD1-AS1 presented high expression in PCa according to results RT-qPCR. As shown by cell counting kit-8 assays, colony formation wound-healing Transwell assays and flow cytometry analyses, silenced suppressed viability, proliferation, migration invasion enhanced apoptosis. Additionally, primarily localised cytoplasm cells. immunoprecipitation...
Nuclear cap-binding protein 2 (NCBP2), as the component of complex, participates in a number biological processes, including pre-mRNA splicing, transcript export, translation regulation and other gene expression steps. However, role NCBP2 on tumor cells immune microenvironment remains unclear. To systematically analyze validate functions NCBP2, we performed pan-cancer analysis using multiple approaches.
α-Cyanostilbene represents one of the easily functionalized aggregation-induced emission (AIE) scaffolds. It has been widely adopted for construction fluorescent materials broad applications. Here, we further expanded utilization α-cyanostilbene derivatives detection hypoxia or proteostasis imbalance in live cells. Four different amine containing donors were introduced to construct (R-ASC) with donor-acceptor Equipped cysteine (Cys) reactive group, maleimide (MI), R-ASC-MI shows fluorescence...
The varying malignancy and lethality of different grades prostate cancer (PCa) highlight the importance accurate diagnosis. This study aims to evaluate upgrading transition zone (TZ) biopsies identify factors improve TZ biopsy accuracy.