A5100407118- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Immune cells in cancer
- Memory and Neural Mechanisms
- MicroRNA in disease regulation
- Trace Elements in Health
- Neurogenesis and neuroplasticity mechanisms
- Neurological Disorders and Treatments
- Dementia and Cognitive Impairment Research
- Stress Responses and Cortisol
- Neurological Disease Mechanisms and Treatments
- Neuroendocrine regulation and behavior
- Adenosine and Purinergic Signaling
- Photochromic and Fluorescence Chemistry
- RNA Research and Splicing
- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
Second Affiliated Hospital of Zhejiang University
2020-2025
Zhejiang University
2020-2023
Zhejiang Lab
2022
Hope Center for Neurological Disorders
2021
Weatherford College
2019
University of California, San Francisco
2012
Gladstone Institutes
2012
Microglia modulate memories Synaptic reorganization and circuit rewiring leads to loss or weakening of connections between neurons may result in the erasure previously formed memories. eliminate excessive synapses developing brain regulate dynamics synaptic throughout life. However, it is still unclear whether forgetting related microglia activity how memory adult brain. Wang et al. discovered that eliminated components hippocampus depleting inhibiting phagocytosis prevented forgetting....
Accumulation of amyloid-β (Aβ), believed to be a key trigger Alzheimer disease (AD), could result from impaired clearance mechanisms. Previously, we showed that the cysteine protease cathepsin B (CatB) degrades Aβ, most likely by C-terminal truncation, in mice expressing human amyloid precursor protein with familial AD-linked mutations (hAPP<sub>FAD</sub>). In addition, Aβ-degrading activity CatB is inhibited its endogenous inhibitor, cystatin C (CysC). Reducing CysC expression markedly...
In premature newborn infants, preterm white matter injury (PWMI) causes motor and cognitive disabilities. Accumulating evidence suggests that PWMI may result from defected differentiation of oligodendrocyte precursor cells (OPCs) impaired maturation oligodendrocytes. However, the underlying mechanisms remain unclear. Using RNAscope, we analyzed expression level RNA-binding protein LIN28A in individual OPCs. Knockout one or both alleles Lin28a OPCs was achieved by administrating tamoxifen to...
Metabotropic glutamate receptor 2 (GRM2) is highly expressed in hippocampal dentate granule cells (DGCs), regulating synaptic transmission and functions. Newborn DGCs are continuously generated throughout life express GRM2 when they mature. However, it remained unclear whether how regulates the development integration of these newborn neurons. We discovered that expression adult-born increased with neuronal mice both sexes. Lack caused developmental defects impaired hippocampus-dependent...
Hippocampal neurogenesis declines with aging. Wnt ligands and antagonists within the hippocampal neurogenic niche regulate proliferation of neural progenitor cells development new neurons, changes their levels in mediate aging-associated decline neurogenesis. We found that RNA-binding protein LIN28A remained existent granule neurons adult hippocampus it decreased Lin28a knockout inhibited responsiveness to agonists reduced neurogenesis, thus impairing pattern separation. Overexpression...
Abstract Background: Vascular dementia (VaD) is the second prevalent worldwide attributable to cognitive impairments. Acupuncture has been applied in clinic as a therapeutic modality treat VaD. This systematic review and meta-analysis aims evaluate current evidence explore effectiveness safety of acupuncture treatment impairment Methods: Randomized controlled trials will be searched restricted their inception from January 1, 2000 September 15, 2019. The following literature databases...