A5110701895- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Autophagy in Disease and Therapy
- Ubiquitin and proteasome pathways
- Endoplasmic Reticulum Stress and Disease
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Intermetallics and Advanced Alloy Properties
- T-cell and B-cell Immunology
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Carcinogens and Genotoxicity Assessment
- Bioactive Compounds and Antitumor Agents
- Advanced ceramic materials synthesis
- Effects and risks of endocrine disrupting chemicals
- Cancer-related Molecular Pathways
- Flavonoids in Medical Research
- Advanced materials and composites
- Atherosclerosis and Cardiovascular Diseases
- Pesticide Exposure and Toxicity
- Ion Channels and Receptors
- Advanced Topology and Set Theory
- Microplastics and Plastic Pollution
- Inflammasome and immune disorders
- Ocular Diseases and Behçet’s Syndrome
University of Macau
2019-2025
Kaohsiung Medical University
2014-2019
Feng Chia University
2015-2016
Institute of Atomic and Molecular Sciences, Academia Sinica
2001
National Taiwan University
2001
Abstract Ubiquitination and deubiquitination are important forms of posttranslational modification that govern protein homeostasis. Deubiquitinating enzymes (DUBs), a superfamily consisting more than 100 members, deconjugate ubiquitin chains from client proteins to regulate cellular However, the dysregulation DUBs is reportedly associated with several diseases, including cancer. The tumor microenvironment (TME) highly complex entity comprising diverse noncancerous cells (e.g., immune stromal...
Systemic autoinflammatory diseases (SAIDs) are rare conditions resulting from innate immune system dysregulation, culminating in repetitive bouts of systemic inflammation without the presence external or self-antigens. Most SAIDs associated with mutations genes affecting response. Tumor necrosis factor (TNF) is a central player pathogenesis numerous chronic inflammatory disorders, and anti-TNF therapy widely used clinical management SAIDs. TNF inhibitors block interaction its two receptors,...
Objectives:The objective of this study was to assess sperm quality and deoxyribonucleic acid (DNA) integrity coke oven workers exposed polycyclic aromatic hydrocarbons (PAHs) as compared control subjects.Material Methods: The (N = 52) administrative staff 35) a steel plant served the groups, respectively.Exposure PAHs assessed by measuring 1-hydroxypyren.Analysis (concentration, motility, vitality, morphology) performed simultaneously with DNA analysis, including fragmentation, denaturation,...
Abstract Di(2‐ethylhexyl)phthalate (DEHP) has been considered as an estrogen receptor alpha (ERα) agonist due to its ability interact with ERα and promote the cell proliferation of ERα‐positive breast cancer cells. The impact DEHP on chemical therapy in is little known. Two lines, MCF‐7 (ERα‐dependent) MDA‐MB‐231 (ERα‐independent) were examined. We found that impaired effectiveness camptothecin (CPT) alleviated CPT‐induced formation reactive oxygen species cells, but not ERα‐negative also...
Objective: Tumor necrosis factor (TNF) receptor type II (TNFR2) is expressed by a wide spectrum of tumor cells including colon cancer, non-Hodgkin lymphoma, myeloma, renal carcinoma and ovarian its exact role remains to be fully understood.In this study, we examined the effect genetic ablation TNFR2 on in vitro vivo growth mouse MC38 CT26 cancer cells.Methods: CRISPR/Cas9 technology was used knockout cells.In colony formation wild-type (W.T.) deficiency cells, as well potential mechanism,...
Plasticizers/phthalates play a facilitating role in the development of cancer and help tumor to grow metastasize. Camptothecin (CPT) its derivatives are known have anticancer properties inhibiting cell growth, promoting apoptosis, increasing autophagy. Therefore, this study, we investigated whether presence di(2-ethylhexyl) phthalate (DEHP) could hinder apoptosis autophagy caused by CPT non-small lung (NSCLC) cells. We found that DEHP interferes with CPT-induced increases prosurvival pathway...
One characteristic of tumor-associated CD4+Foxp3+ regulatory T cells (Tregs) is the high expression tumor necrosis factor receptor type II (TNFR2), a that mediates decisive effect (TNF) in activation and expansion Tregs. There increasing evidence inhibition TNFR2 can enhance anti-tumor immune responses. Therefore, we screened Chinese herbal extracts for their capacity to block TNF-TNFR2 interaction. The results showed treatment with herb extract could inhibit TNFR2-induced biological...
Hepatocellular carcinoma (HCC) is a leading cancer worldwide. Advanced HCCs are usually resistant to anticancer drugs, causing unsatisfactory chemotherapy outcomes. In this study, we showed that 4-phenoxyphenol derivative, 4-[4-(4-hydroxyphenoxy)phenoxy]phenol (4-HPPP), exerts an inhibitory activity against two HCC cell lines, Huh7 and Ha22T. We further investigated the anti-HCC activities of 4-HPPP, including anti-proliferation induction apoptosis. Our results higher dosage 4-HPPP...
Thalidomide (THD), a synthetic derivative of glutamic acid, was initially used as sedative and antiemetic until the 1960s, when it found to cause devastating teratogenic effects. However, subsequent studies have clearly demonstrated anti-inflammatory, anti-angiogenic, immunomodulatory properties thalidomide, thus providing rationale for its current use in treatment various autoimmune diseases cancers. Our group that thalidomide can suppress regulatory T cells (Tregs), minor subset CD4+...
Inhibition of TPCs up-regulates tmTNF expression on APCs by disrupting mTACE and promotes expansion TNFR2 + Tregs.
Unfolded protein response (UPR) is a cytoprotective mechanism that alleviates the protein-folding burden in eukaryotic organisms. Moderate activation of UPR required for maintaining endoplasmic reticulum (ER) homeostasis and profoundly contributes to tumorigenesis. Defects signaling are implicated attenuation various malignant phenotypes including cell proliferation, migration, invasion, as well angiogenesis. This suggests promising target cancer therapy. The pharmacological effects plant...
High levels of tumor necrosis factor receptor type II (TNFR2) are preferentially expressed by immunosuppressive CD4 + Foxp3 regulatory T cells (T regs ), especially those present in the microenvironment, as initially reported us. There is compelling evidence that targeting TNFR2 markedly enhances antitumor immune responses. Furthermore, a broad spectrum human cancers also expresses TNFR2, while its expression normal tissue very limited. We thus hypothesized may be harnessed for...
Abstract Titanium silicide (Ti 5 Si 3 ) was fabricated by self-propagating high-temperature synthesis (SHS) from the elemental powder compact. With increase of sample density 50 to 60% TMD, experiments showed that flame-front velocity increased 28 mm/s and combustion temperature 1,580 1,700°C. Based on their dependence, activation energy reaction, E a =193 kJ/mol, deduced. By numerical simulation wave kinetics, Arrhenius factor rate function, K 0 =3×10 9 s −1 , determined for 5Ti + 3Si...
The photodissociation of 1,2-C2H2Br2 at 248 nm has been studied by product translational spectroscopy. results show that the molecule dissociates exclusively into products (1) Br2+C2H2 and (2) Br (fast)+Br (slow)+C2H2 with a branching ratio ∼0.2:0.8. While cleavages C–Br bonds are not symmetric, producing atoms unequal velocities, anisotropy indicates both reactions occur in fraction rotational period. Following an asynchronous concerted reaction, triple were simulated P(Et) distributions...