A5111682544- Genetic and phenotypic traits in livestock
- Milk Quality and Mastitis in Dairy Cows
- Cancer-related molecular mechanisms research
- Cocoa and Sweet Potato Agronomy
- Digestive system and related health
- RNA Research and Splicing
- Advances in Cucurbitaceae Research
- Circular RNAs in diseases
- Plant Molecular Biology Research
- RNA modifications and cancer
- Infant Nutrition and Health
- Animal Genetics and Reproduction
- Insect Resistance and Genetics
- Studies on Chitinases and Chitosanases
- Electron Spin Resonance Studies
- Genomics and Chromatin Dynamics
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Fatty Acid Research and Health
- Antimicrobial Peptides and Activities
- Enzyme Production and Characterization
- Plant tissue culture and regeneration
- T-cell and Retrovirus Studies
- Genetics and Neurodevelopmental Disorders
- E-Government and Public Services
- Lepidoptera: Biology and Taxonomy
Wuhan University
2024
Hefei University of Technology
2015-2024
Nanjing Agricultural University
2011-2023
University of Chicago
2023
Nanjing University of Science and Technology
2023
Howard Hughes Medical Institute
2023
Ministry of Agriculture and Rural Affairs
2021-2022
Bengbu Medical College
2022
Anhui Normal University
2011-2019
Anhui Agricultural University
2018
Overgeneration of reactive oxygen species (ROS) is closely associated with cellular damage and diseases. As superoxide anion (O2•–) the precursor other ROS, exploring O2•– fluctuations in cells vivo great significance. To address this critical need, we have developed a novel reversible fluorescent probe one-photon two-photon fluorescence properties, which well suited for monitoring fluxes selectively dynamically. Imaging results substantiate dynamic responses to intracellular under apoptotic...
RNA-binding proteins (RBPs) control messenger RNA fate in neurons. Here, we report a mechanism that the stimuli-induced neuronal translation is mediated by phosphorylation of YTHDF1-binding protein FMRP. Mechanistically, YTHDF1 can condense with ribosomal to promote its mRNA targets. FMRP regulates this process sequestering away from ribosome; upon stimulation, becomes phosphorylated and releases for upregulation. We show new small molecule inhibitor reverse fragile X syndrome (FXS)...
Parthenocarpy is an important agronomic trait in cucumber (Cucumis sativus L.) production. However, the systematic identification of parthenocarpic germplasms from national gene banks for improvement remains international challenge. In this study, 201 lines were investigated, including different ecotypes. The percentages fruit set (PFS) and expansion (PFE) evaluated three experiments. natural populations, PFS rates fit a normal distribution, while PFE showed skewed suggesting that both are...
The β-glucan from Saccharomyces cerevisiae is a potent adjuvant that exhibits broad spectrum of biological activities and health benefits, different processes have been established to prepare active yeast. However, studies concerning the effect β-1,6-glucanase enzymolysis on structure immunomodulatory activity yeast β-1,3-glucan are scarce. In this study, we aim develop novel enzymatic process for preparation immunologically (BYG) baker's using GluM. β-1,6-glucan in fungal cell wall was...
The pine moth Dendrolimus punctatus (Walker) is a common insect pest that confers serious damage to conifer forests in south of China. Extensive physiology and ecology studies on D. have been carried out, but the lack genetic information has limited our understanding molecular mechanisms behind its development resistance. Using RNA-seq approach, we characterized transcriptome this investigated developmental expression profiles during egg, larval, pupal, adult stages. A total 107.6 million...
Bovine mastitis is a common inflammatory disease caused by multiple factors in early lactation or dry period. Genome wide association studies (GWAS) can provide convenient and effective strategy for understanding the biological basis of better prevention. 2b-RADseq high-throughput sequencing technique that offers powerful method genome-wide genetic marker development genotyping. In this study, single nucleotide polymorphisms (SNPs) immune-regulated gene correlative with were screened...
Xishuangbanna (XIS) cucumber (Cucumis sativus L. var. xishuangbannesis Qi et Yuan), is a botanical variety of cultivars native to southwest China that possesses excellent agronomic traits for improvement. However, breeding utilization XIS limited due the current poor understanding its photoperiod-sensitive flowering characteristics. In this study, genetic and transcriptomic analysis were conducted reveal molecular basis photoperiod-regulated in cucumber. A major-effect QTL locus DFF1.1 was...
LncRNAs are regarded as regulators in various animal reproductive physiological processes. However, the regulation of lncRNAs organ development Hu sheep with different prolificacy remains unknown. Herein, numerous tissue-unique and -common differentially expressed (DELs) genes (DEGs), fecundity-unique DELs DEGs were identified among comparison groups at horizontal vertical levels. Moreover, -common, female reproduction-associated screened, interaction networks constructed. Furthermore,...
Neuromedin S (NMS) plays various roles in reproductive regulation, while the mechanism by which NMS regulates ovarian steroidogenesis remains unclear. In current study, we confirmed enhancement role of goat granulosa cells (GCs). To further explore specific mechanism, conducted a knockdown NMUR2 GCs followed treatment with and determined effects on mitochondrial morphology function. The results found that increased production estrogen up-regulated expression STAR, CYP11A1, 3BHSD, CYP19A1,...
Mammary gland epithelium, as the first line of defense for bovine mammary immunity, is crucial in process glands’ innate especially that epithelial cells (bMECs). Our previous studies successfully marked SYK an important candidate gene mastitis traits via GWAS and preliminarily confirmed expression down-regulated bMECs with LPS (E. coli) stimulation, but its work mechanism still unclear. In this study, time, vivo, TLR4 were colocalized had a high correlation epithelium; protein−protein...
With the rapid development of digital technology, role digitalisation in urban governance continues to emerge. Building a theoretical analysis framework and evaluation system digitally driven has important practical significance for stimulating efficiency technology tools improving energy level governance. This paper aims explore mechanism enabled by innovatively change previous thinking mode that only attaches importance facility construction e-government platforms, adopt ecological...
Alpha-lactalbumin (α-LA) is a major whey protein in bovine and other mammalian milk, which regulates synthesis of lactose. Little known about its genetic polymorphism whether can be used as potential marker for dairy ingredients, milk yield traits, properties. To investigate polymorphisms their relationship with lactation traits Chinese Holstein cows, single-strand conformation method (PCR-SSCP) direct sequencing were to mark the α-LA gene SNPs. AA (0.7402) AB (0.2598) genotypes screened out...
Abstract Although long non‐coding RNAs (lncRNAs) are reported to regulate follicular development and reproductive disease pathogenesis, the underlying mechanisms have not been elucidated. In this study, lncRNA expression profiling of different‐sized healthy follicles from Hu sheep with different prolificacy revealed 50 613 lncRNAs. Numerous lncRNAs were differentially expressed among comparison groups. This study characterized one novel transcript, lncRNA‐412.25 (from a diameter >5 mm),...
Cranes are monomorphic birds and it is difficult to determinate their sexes. Polymerase chain reaction was conducted amplify the female-specific segments on chromo-helicase-DNA binding 1 gene, using specially designed primers. The products were cloned into vector pMD-18T, transformed Escherichia coli DH-5α sequenced. sequences have been submitted National Center for Biotechnology Information (NCBI) (GenBank Accession Number: AY366489, AY366703, AY367004, AY367005, AY377921), aligned by...
Abstract Background Bovine mastitis is a key disease restricting developing global dairy industry. Genomic wide association studies (GWAS) provided convenient way to understand the biological basis of and better prevent or treat disease. 2b-RADseq reduced-representation sequencing that offered powerful method for genome-wide genetic marker development genotyping. This study, GWAS using two-stage analysis identified important genes’ single nucleotide polymorphisms (SNP) in Chinese Holstein...