A5032942637- RNA Research and Splicing
- Horticultural and Viticultural Research
- RNA modifications and cancer
- Fermentation and Sensory Analysis
- Plant Gene Expression Analysis
- RNA and protein synthesis mechanisms
- RNA regulation and disease
- Cancer-related gene regulation
- Chemical Synthesis and Analysis
- Skin and Cellular Biology Research
- Genetic Neurodegenerative Diseases
- Protein Structure and Dynamics
- Plant Pathogens and Fungal Diseases
- Cancer-related molecular mechanisms research
- Receptor Mechanisms and Signaling
- Protein Degradation and Inhibitors
- Plant Reproductive Biology
- Advanced Synthetic Organic Chemistry
- Berberine and alkaloids research
- Silk-based biomaterials and applications
- Machine Learning in Bioinformatics
- Asthma and respiratory diseases
- Icing and De-icing Technologies
- Enzyme-mediated dye degradation
- Microbial Metabolism and Applications
Xinjiang Academy of Agricultural Sciences
2020-2025
Westlake University
2025
The University of Texas Southwestern Medical Center
2018-2024
Southwestern Medical Center
2019-2024
Guangzhou Medical University
2024
Wenzhou Medical University
2020-2023
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2023
GlaxoSmithKline (United States)
2007-2022
Providence College
2022
Zhengzhou University
2014-2021
Protein domains of low sequence complexity do not fold into stable, three-dimensional structures. Nevertheless, proteins with these sequences assist in many aspects cell organization, including assembly nuclear and cytoplasmic structures surrounded by membranes. The dynamic nature cellular assemblies is caused the ability low-complexity (LCDs) to transiently self-associate through labile, cross-β Mechanistic studies useful for study LCD self-association have evolved over past decade form...
Abstract The YTH N 6 -methyladenosine RNA binding proteins (YTHDFs) mediate the functional effects of (m A) on RNA. Recently, a report proposed that all YTHDFs work redundantly to facilitate decay, raising questions about exact functions individual YTHDFs, especially YTHDF1 and YTHDF2. We show YTHDF2 differ in their low-complexity domains (LCDs) exhibit different behaviors condensate formation subsequent physiological functions. Biologically, we also find global stabilization after depletion...
RNA-binding proteins (RBPs) control messenger RNA fate in neurons. Here, we report a mechanism that the stimuli-induced neuronal translation is mediated by phosphorylation of YTHDF1-binding protein FMRP. Mechanistically, YTHDF1 can condense with ribosomal to promote its mRNA targets. FMRP regulates this process sequestering away from ribosome; upon stimulation, becomes phosphorylated and releases for upregulation. We show new small molecule inhibitor reverse fragile X syndrome (FXS)...
Crop resilience measures must be strengthened in response to the global climate impact. Temperature stress exacerbates impact on crop growth and grain yield, threatening sustainability of grapevine production dependent wine industries. Grape (Vitis spp.) is one most widely cultivated fruit crops world, as well economically important fruit. However, grape yield quality are highly environmental conditions, particularly temperature stress. Understanding molecular mechanisms that control...
Human genetic studies have given evidence of familial, disease-causing mutations in the analogous amino acid residue shared by three related RNA binding proteins causative neurological diseases. Alteration aspartic 290 hnRNPA2 to valine is believed predispose patients multisystem proteinopathy. Mutation 262 hnRNPA1 either or asparagine has been linked amyotrophic lateral sclerosis 378 hnRNPDL histidine associated with limb girdle muscular dystrophy. All these residues map evolutionarily...
Significance The TDP43 RNA binding protein is frequently aggregated in the brain tissue of patients suffering from neurodegenerative diseases. Human genetic studies ALS have identified scores missense mutations clustered within a localized region protein. This low sequence complexity and has been thought to exist state structural disorder under conditions proper function. present study gives evidence that domain self-associates into specific conformation may be important its normal...
Low complexity (LC) head domains 92 and 108 residues in length are, respectively, required for assembly of neurofilament light (NFL) desmin intermediate filaments (IFs). As studied isolation, these IF interconvert between states conformational disorder labile, β-strand-enriched polymers. Solid-state NMR (ss-NMR) spectroscopic studies NFL domain polymers reveal spectral patterns consistent with structural order. A combination intein chemistry segmental isotope labeling allowed preparation...
In viticulture, grafting has been practiced widely and influences grape development as well berry wine quality. However, there is limited understanding of the effects rootstocks on phenolic compounds, which are located primarily in skin contribute to certain sensory attributes wine. this study, scion-rootstock interactions were investigated at green-berry stage veraison when grapevines hetero-grafted with three commonly used rootstock genotypes (5BB, 101-14MG, SO4). Physiological...
Abstract Grafting, which joins a scion from cultivar with the stem of rootstock grapevine wild relative, is commonly used in viticulture. Grafting has crucial effects on various phenotypes cultivar, including its phenology, biotic and abiotic resistance, berry metabolome, coloration, but underlying genetics regulatory mechanisms are largely unexplored. In this study, we investigated phenotypic, metabolomic, transcriptomic profiles at three developmental stages (45, 75, 105 days after...
An evolutionarily conserved region of the TDP-43 low-complexity domain (LCD) twenty residues in length can adopt either an α-helical or β-strand conformation. When latter conformation, self-associates via formation a labile, cross-β structure. Self-association be monitored phase-separated protein droplets. Exposure droplets to hydrogen peroxide leads oxidation methionine distributed throughout LCD. Oxidation disassembles structure, thus eliminating both self-association and phase separation....
Xinjiang is the largest grape-producing region in China and main grape cultivation area world. The Eurasian resources grown are very rich diversity. sugar composition content factors that determine quality of berries. However, there currently no systematic reports on types contents sugars grapes region. In this research, we evaluated appearance fruit maturity indicators 18 varieties during ripening determined their using GC-MS. All cultivars primarily contained glucose, D-fructose, sucrose....
Abstract Protein domains of low sequence complexity are unable to fold into stable, three-dimensional structures. In test tube studies, these unusual polypeptide regions can self-associate in a manner causing phase separation from aqueous solution. This form protein:protein interaction has been implicated numerous examples dynamic morphological organization within eukaryotic cells. several cases, the basis for domain (LCD) self-association and traced formation labile cross-β The primary...
Protein domains of low sequence complexity are unable to fold into stable, three-dimensional structures. In test tube studies, these unusual polypeptide regions can self-associate in a manner causing phase separation from aqueous solution. This form protein:protein interaction has been implicated numerous examples dynamic morphological organization within eukaryotic cells. several cases, the basis for domain (LCD) self-association and traced formation labile cross-β The primary energetic...
An efficient asymmetric synthesis of N-[(1R)-6-chloro-2,3,4,9-tetrahydro-1H-carbazol-1-yl]-2-pyridinecarboxamide 1, a potential treatment for human papillomavirus infections, is described. The key step in the this molecule an reductive amination directed by chiral (phenyl)ethylamines resulting up to 96% disastereo facial selectivity. also highlighted isolation unique 2-picolinic acid salt (1R)-6-chloro-2,3,4,9-tetrahydro-1H-carbazol-1-amine (13). Subsequent application 1-propylphosphonic...
Abstract Background Atopic dermatitis is one of the most common skin disorders. Evidence has suggested an association between disorders, such as atopic dermatitis, and Parkinson's disease (PD). However, whether a causal effect on PD remains unknown. Methods The study aimed to determine their causal, using bidirectional two‐sample Mendelian randomization method. Genetic variants from public genome‐wide studies for ( n = 10788 cases 30047 controls) were selected evaluate effects risk (33,674...
Caloric restriction (CR) might be effective for alleviating/preventing Alzheimer's disease (AD), but the biological mechanisms remain unclear. In current study, we explored whether CR caused an alteration of gut microbiome and resulted in attenuation cognitive impairment AD animal model.
Practical and scalable syntheses were developed that used to prepare multikilogram batches of GSK1292263A (1) GSK2041706A (15), two potent G protein-coupled receptor 119 (GPR119) agonists. Both employed relatively cheap readily available starting materials, both took advantage an SNAr synthetic strategy.
The Munake grape cultivar produces uniquely flavored and high-quality fruits. Despite the numerous beneficial agronomic traits of Munake, there are few genetic resources available for this cultivar. To address knowledge gap, entire genome was sequenced using whole-genome sequencing approaches compared with a Vitis vinifera L. reference genome. This study describes more than 3 million single nucleotide polymorphism (SNP), 300,000 insertion deletion (InDel), 14,000 structural variation (SV),...