A5024354411- COVID-19 Clinical Research Studies
- Vascular Procedures and Complications
- Venous Thromboembolism Diagnosis and Management
- Congenital Heart Disease Studies
- COVID-19 and healthcare impacts
- HIV/AIDS Research and Interventions
- Central Venous Catheters and Hemodialysis
- SARS-CoV-2 and COVID-19 Research
- Cardiac Fibrosis and Remodeling
- Viral Infections and Immunology Research
- Cardiovascular Function and Risk Factors
- Cytomegalovirus and herpesvirus research
- Transplantation: Methods and Outcomes
- Long-Term Effects of COVID-19
- HIV, Drug Use, Sexual Risk
- HIV/AIDS drug development and treatment
- Mechanical Circulatory Support Devices
- HIV Research and Treatment
- COVID-19 Impact on Reproduction
- Cardiac Structural Anomalies and Repair
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Issues in Pregnancy
- Phagocytosis and Immune Regulation
- Chemokine receptors and signaling
- Cardiovascular and exercise physiology
Memorial Healthcare System
2017-2025
Memorial Regional Hospital
2017-2024
University of Central Florida
2011-2023
Florida College
2021-2023
Joe DiMaggio Children's Hospital
2020-2022
Memorial Health System
2022
Florida International University
2022
Texas Children's Hospital
2020
Baylor College of Medicine
2020
Central South University
2013
Monocyte chemoattractant protein-1 (MCP-1; CCL2)–mediated inflammation plays a critical role in the development of ischemic heart disease (IHD). However, gene expression changes caused by signal transduction, triggered MCP-1 binding to its receptor CCR2, and their possible IHD are not understood. We present evidence that CCR2 induces novel transcription factor (MCP-induced protein [MCPIP]) causes cell death. Gene microarray analysis showed when expressed hiuman embryonic kidney 293 cells,...
Endoplasmic reticulum (ER) stress has been found to be associated with neurodegenerative diseases and diabetes mellitus. Whether ER is involved in the development of heart disease not known. Cardiac-specific expression monocyte chemoattractant protein-1 (MCP-1) mice causes ischemic disease. Here we report that microarray analysis gene changes these transgenic revealed a cluster stress-related genes was transcriptionally activated during The array results were verified by quantitative...
Monocyte chemotactic protein-1 (MCP-1) has been recognized as an angiogenic chemokine. The molecular mechanism of MCP-1-mediated angiogenesis remains unknown. We recently identified a novel transcription factor, designated MCP-1-induced protein (MCPIP), in human monocytes after treatment with MCP-1. investigated whether is mediated via MCPIP. Treatment umbilical vein endothelial cells (HUVECs) MCP-1 induced expression MCPIP and capillary-like tube formation. Knockdown by small interfering...
Cigarette smoke contains and generates a large amount of reactive oxygen species (ROS) that affect normal cellular function have pathogenic consequences in the cardiovascular system. Increased oxidative stress inflammation are considered to be an important mechanism injury induced by cigarette smoke. Antioxidants may serve as effective therapeutic agents against smoke-related disease. Because presence vacancies on its surface self-regenerative cycle dual oxidation states, Ce<sup>3+</sup>...
Abstract Macrophage polarization plays a critical role in tissue homeostasis, disease pathogenesis, and inflammation its resolution. IL-4–induced macrophage involves induction of STAT6 Krüppel-like factor 4 (KLF4), which induce each other promote M2 polarization. However, how these transcription factors implement is not understood. We report that murine macrophages MCP-1–induced protein (MCPIP), induced by KLF4, inhibits M1 inhibiting NF-κB activation implements using both deubiquitinase...
Osteoclasts (OCs) are responsible for bone resorption in inflammatory joint diseases. Monocyte chemotactic protein-1 (MCP-1) has been shown to induce differentiation of monocytes OC precursors, but nothing is known about the underlying mechanisms. Here, we elucidate how MCPIP, induced by MCP-1, mediates this differentiation. Knockdown MCPIP abolished MCP-1-mediated expression markers, tartrate-resistant acid phosphatase, and serine protease cathepsin K. Expression p47PHOX its membrane...
Lymphopenia is commonly present in patients with COVID-19. We sought to determine if lymphopenia on admission predicts COVID-19 clinical outcomes. A retrospective chart review was performed 4485 laboratory-confirmed COVID-19, who were admitted the hospital. Of those, 2409 (57.3%) presented (absolute lymphocyte count < 1.1 × 109/L) admission, and had higher incidences of ICU (17.9% versus 9.5%, p 0.001), invasive mechanical ventilation (14.4% 6.5%, dialysis (3.4% 1.8%, 0.001) in-hospital...
Monocyte chemotactic protein-1-induced protein 1 (MCPIP1) is highly expressed in inflamed mucosa of inflammatory bowel disease (IBD) and negatively regulates immune response, while the underlying mechanisms regulating mucosal macrophage functions remain unknown. Here, we investigated roles MCPIP1 modulating differentiation intestinal macrophages pathogenesis IBD.ScRNA-seq was used to cluster monocyte/macrophage lineage from macrophage-specific Mcpip1-deficient (Mcpip1∆Mye) mice Mcpip1fl/fl...
Abstract Background Emergency department (ED)-based “Opt-Out” HIV testing is critical to access prevention and care services. Due the COVID-19 pandemic, disruptions in medical services might have affected uptake. The number of tests per month ED-based settings Memorial Healthcare System between July 2018 February 2024. A, Pre-COVID-19 phase; B, pandemic C, Post-pandemic phase. MPC, monthly percent changeFigure 1.Multiple joinpoint models showing temporal trends MHealthcare change. Methods We...
Abstract Background Syphilis, a sexually transmitted infection caused by the bacterium Treponema pallidum, has been increasing in incidence both locally and globally. Visualizing analyzing time series trends of syphilis across different demographics geographic locations, how they varied during COVID-19 pandemic, would help to develop strategies address rising rates.Figure 1.Trends age-standardized rates Florida, 2013 - 2022, stratified sex, racial age groups.(A) ASSR sex; (B) groups; (C)...
Doxorubicin (Dox) is known to cause cardiomyopathy and congestive heart failure upon chronic administration. The mechanisms underlying these toxicities remain uncertain but have been attributed, at least in part, by induction of cardiac cell apoptosis. Fas ligation with its cognate ligand (FasL) induces apoptosis activates cellular inflammatory responses associated tissue injury. We determined whether interruption Fas/FasL interaction cardiac-targeted expression soluble (sFas), a competitive...
Monocytic cells enhance neovascularization by releasing proangiogenic mediators and/or transdifferentiating into endothelial-like cells. However, the mechanisms that govern this transdifferentiation process are largely unknown. Recently, monocyte chemotactic protein-1 (MCP-1)-induced protein (MCPIP) has been identified as a novel CCCH-type zinc-finger expressed primarily in monocytic Here, we analyzed whether MCPIP might exert angiogenic effects promoting differentiation of endothelial cell...
Patent foramen ovale (PFO) is seen in 25% of the general population but up to 50% patients ≤60 years old with cryptogenic strokes. Trials have shown that PFO closure vs medical therapy reduces risk future may cause atrial fibrillation (AF), prior trials reporting an incidence 2% 11.9%. However, true AF after unknown due limitations studies for long-term monitoring.