A5100752914- Osteoarthritis Treatment and Mechanisms
- Extracellular vesicles in disease
- Inflammatory mediators and NSAID effects
- Target Tracking and Data Fusion in Sensor Networks
- Acute Myeloid Leukemia Research
- Orthopedic Infections and Treatments
- RNA modifications and cancer
- Bone Tissue Engineering Materials
- Spinal Fractures and Fixation Techniques
- Circular RNAs in diseases
- Infectious Diseases and Tuberculosis
- Radar Systems and Signal Processing
- Single-cell and spatial transcriptomics
- Membrane-based Ion Separation Techniques
- Neurogenetic and Muscular Disorders Research
- Seismology and Earthquake Studies
- Advanced Steganography and Watermarking Techniques
- Advanced SAR Imaging Techniques
- Chemokine receptors and signaling
- Supercapacitor Materials and Fabrication
- Bone and Dental Protein Studies
- Pharmacological Effects of Medicinal Plants
- Inertial Sensor and Navigation
- Satellite Communication Systems
- Management of metastatic bone disease
Southeast University
2023-2024
Sun Yat-sen University
2018-2024
The Seventh Affiliated Hospital of Sun Yat-sen University
2018-2024
First Affiliated Hospital of Henan University of Science and Technology
2024
The First Affiliated Hospital, Sun Yat-sen University
2021-2023
First Affiliated Hospital of Jinan University
2023
Third Affiliated Hospital of Sun Yat-sen University
2023
AO Foundation
2021-2022
Qilu University of Technology
2021
Bridge University
2020
It has been proven that the mechanical microenvironment can impact differentiation of mesenchymal stem cells (MSCs). However, effect stimuli in biofabricating hydroxyapatite scaffolds on inflammatory response MSCs remains unclear. This study aimed to investigate loading seeded scaffolds. Cyclic was applied biofabricate cell-scaffold composite for 15 min/day over 7, 14, or 21 days. At predetermined time points, culture supernatant collected mediator detection, and gene expression analyzed by...
Capacitive deionization (CDI), as an energy-efficient and promising brackish water desalination technique, has certain advantages over conventional methods such thermal distillation, ultrafiltration, reverse osmosis. However, CDI technology is yet not widely applied it can only treat low salinity due to the limitation of salt adsorption capacity electrode. The complexity high cost preparation materials with excellent removal capability also hinder commercialization technology. To surmount...
Abstract Background There is no comparative study with long-term follow-up between posterior-only and combined posterior-anterior approaches in treating lumbar spinal tuberculosis (LSTB) lumbosacral (LSSTB). This retrospective aimed to compare evaluate the outcomes of these two surgical LSTB LSSTB. Methods Thirty patients 12 LSSTB underwent approach (group A); 26 14 were managed B). Analysis comparison clinical radiographic groups performed. Results The intra-operative bleeding amount,...
Aim: To explore the potential functions and mechanism of N6.methyladenosine (m6A) abnormality RNAs in nucleus pulposus from intervertebral disc degeneration (IDD). Materials & methods: We performed rat model, m6A epitranscriptomic microarray, bioinformatics analysis metabolomics. Results: In IDD, most differentially methylated showed a significant demethylation situation. The competing endogenous RNA network LOC102555094/miR-431/GSK-3β combining downstream Wnt pathway were identified...
Abstract Although we previously reported that the self-renewal of leukemia-initiating cells B-lineage acute lymphoblastic leukemia (B-ALL LICs) was regulated by β -Arrestin1, a multiple-function protein, cellular senescence is critical for LICs fate and progress, worthy further investigation. Here found depletion β-Arrestin1 extended population doubling time percentage senile cells, signatures senescence, B-ALL LICs. Moreover, lack enhanced expression proteins (CBX, HIRA) genes ( P53 , P16 )...
The osteogenic microenvironment of bone-repairing materials plays a key role in accelerating bone regeneration but remains incompletely defined, which significantly limits the application such bioactive materials. Here, transcriptional landscapes different microenvironments, including three-dimensional (3D) hydroxyapatite (HA) scaffolds and medium (OM), for mesenchymal stromal cells (MSCs) vitro were mapped at single-cell resolution. Our findings suggested that an process reminiscent...
Abstract Background The single-cell platform provided revolutionary way to study cellular biology. Technologically, a sophistic protocol of isolating qualified single cells would be key deliver platform, which requires high cell viability, yield and low content aggregates or doublets. For musculoskeletal tissues, like bone, cartilage, nucleus pulposus tendons, as well their pathological state, are tense dense, it’s full challenge efficiently rapidly prepare suspension. Conventionally,...
Spinal muscular atrophy (SMA) is the most common autosomal recessive disease in children, and diagnosis complicated difficult, especially at early stage. Early of SMA able to improve outcome patients. In our study, Real-time PCR was developed measure gene mutation or deletion key genes for further analyse genotype-phenotype correlation.The multiple real-time detecting mutations survival motor neuron (SMN), apoptosis inhibitory protein (NAIP) general transcription factor IIH, polypeptide 2...
The altered concentrations of amino acids were found in the bone marrow or blood leukemia patients. Metabolomics technology combining mathematical model biomarkers could be used for assisting diagnosis pediatric acute (AL). 17 was measured by targeted liquid chromatograph–tandem mass spectrometry periphery collected using dried spots. After evaluation, models further evaluated prospective clinical validation cohort AL diagnosis. 13 statistically different between serum dots LC–MS/MS....
Osteoarthritis (OA) is the most common degenerative joint disease, mainly affecting elderly worldwide, for which drug treatment remains a major challenge. Low-grade inflammation plays pivotal role in OA onset and progression. Exploration of notable anti-inflammatory disease-modifying drugs on human samples could facilitate evaluation therapeutic strategies OA. The 5-aminosalicylic acid (5-ASA) first-line ulcerative colitis (UC), however no study has explored effects 5-ASA articular...
Osteoarthritis (OA) is the most common joint disease worldwide; however, disease-modifying treatments are lacking because of complicated pathological mechanisms. As a breakthrough, aberrant activation transforming growth factor-β 1 (TGF-β1)in subchondral bone has been confirmed as an essential pathomechanism for OA progression, and become potential therapeutic target. In addition to R&D on neutralizing antibodies, small-molecule antagonists chemical medicines, native TGF-β1 could be...
Osteoarthritis (OA) is the most common degenerative joint disease without clear pathophysiological mechanism and effective drugs for treatment. Although various animal models exist, translation of outcome into clinics remains difficult due to species differences. In this study, an ex vivo inflammatory OA model was induced using different concentrations interleukin one beta (IL-1β) tumor necrosis factor α (TNF-α) on explants from human femoral head. groups, gene expression levels cartilage...
This paper mainly addresses the dim target detection and tracking problems in multiple pulse repetition frequency (MPRF) radar system using multi-frame track-before-detect (MF-TBD) method. Generally, each measurement frame received by MPRF faces range Doppler ambiguities at specific (PRF) setting. We have proposed a multi-PRF TBD (MPMF-TBD) algorithm [1], which provides an energy-efficient solution to accomplish kinematic state estimation ambiguity resolution simultaneously. However, this...
Abstract We previously demonstrated that inhibiting neural stem cells necroptosis enhances functional recovery after spinal cord injury. While exosomes are recognized as playing a pivotal role in exocrine function, their precise function injury remains unclear. To investigate the of generated following injury, we conducted single–cell RNA sequencing and validated originate from ependymal undergo response to Subsequently, established an vitro model using isolated embryonic mice aged 16-17...
With the penetration of multi-source and multi-type distributed generation (DG) in distribution network, power flow calculations network become more complex. On premise analysis calculation model for different DG, this paper presents a pa rallel computing algorithm complex based on multicore CPU technique. basis topological structure system, task assignment problems isomorphism processors were solved to improve speedup ratio parallel efficiency. Integrated with characteristics...