A5069922671- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
Henan Provincial Chest Hospital
2019
Circular RNA (circRNA) is a new class of non-coding that plays pivotal role in carcinogenesis. Recently, circ-MTO1 (hsa_circ_0007874) was shown to be cancer-related circRNA. However, its lung adenocarcinoma (LUAD) has not been reported. Here, we found significantly down-regulated LUAD, which closely associated with malignant features and dismal prognosis. Enforced expression suppressed the growth LUAD cells both vitro vivo. Subsequent mechanism experiments showed served as sponge oncogenic...
It is well recognized that competing endogenous RNA (ceRNA) regulatory network linked to the development and progression of cancer, including non-small cell lung cancer (NSCLC). Herein, we aimed explore functional role circ-CMPK1/miR-302e/cyclin D1 ceRNA signaling in NSCLC.GEO database (GSE102287) was utilized screen differentially expressed miRNAs NSCLC. Quantitative reverse transcription PCR (qRT-PCR) western blotting assays were used determine gene expression. Cell proliferation analysis...