A5035728283- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Pancreatic function and diabetes
- Diabetes Management and Research
- Epilepsy research and treatment
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Diabetes and associated disorders
- Advanced MRI Techniques and Applications
- Neonatal and fetal brain pathology
- Prenatal Substance Exposure Effects
- Neurological disorders and treatments
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Cardiac electrophysiology and arrhythmias
- Barrier Structure and Function Studies
University of Toronto
2015-2024
University Health Network
2018-2021
Krembil Research Institute
2018-2021
Toronto Public Health
2016
Abstract Postictal generalized EEG suppression is the state of electrical activity at end a seizure. Prolongation this has been associated with increased risk sudden unexpected death in epilepsy, making characterization underlying rhythmic during postictal an important step improving epilepsy treatment. Phase-amplitude coupling reflects cognitive coding within brain networks and some those codes highlight epileptic activity; therefore, we hypothesized that there are distinct phase-amplitude...
Epilepsy is a common neurological disorder characterized by naturally-occurring spontaneous recurrent seizures and comorbidities. Kindling has long been used to model epileptogenic mechanisms assess antiepileptic drugs. In particular, extended kindling can induce without gross brain lesions, as seen clinically. To date, the development of following kindling, effect drugs on these are not well understood. present study we aim develop mouse hippocampal for first time. Once established, plan...
A method to improve the genetic engineering of microtissues by increasing viral particle penetration using a microfluidic device.
Abstract Epilepsy is a chronic neurological disorder characterized by spontaneous recurrent seizures (SRS) and comorbidities. Kindling through repetitive brief stimulation of limbic structure commonly used model temporal lobe epilepsy. Particularly, extended kindling over period up to few months can induce SRS, which may simulate slowly evolving epileptogenesis Currently, electroencephalographic (EEG) features SRS in rodent models remain be detailed. We explored this using mouse hippocampal...
Sudden unexpected death in epilepsy (SUDEP) is the leading seizure-related cause of patients. There are no validated biomarkers SUDEP risk. Here, we explored peri-ictal differences topological brain network properties from scalp EEG recordings victims. Functional connectivity networks were constructed and examined as directed graphs derived undirected delta high frequency oscillation (HFO) coherence eight 14 non-SUDEP epileptic These proxies for information flow at different spatiotemporal...
Previous case-control studies of sudden unexpected death in epilepsy (SUDEP) patients failed to identify ECG features (peri-ictal heart rate, rate variability, corrected QT interval, postictal recovery, and cardiac rhythm) predictive SUDEP risk. This implied a need derive novel metrics assess risk from ECG.We applied Single Spectrum Analysis Independent Component (SSA-ICA) remove artifact recordings. Then cross-frequency phase-phase coupling (PPC) was 20-s mid-seizure window contour -3 dB...
Abstract Objective Approximately 50 million people worldwide have epilepsy and 8-17% of the deaths in patients with are attributed to sudden unexpected death (SUDEP). The goal present work was establish a biomarker for SUDEP so that preventive treatment can be instituted. Approach Seizure activity non-SUDEP analyzed, specifically, scalp EEG extracted muscle (SMA) average wavelet phase coherence (WPC) during seizures computed two frequency ranges (1-12 Hz, 13-30 Hz) identify differences...
Approximately 50 million people worldwide have epilepsy and 8-17% of the deaths in patients with are attributed to sudden unexpected death (SUDEP). The goal present work was establish a biomarker for SUDEP so that preventive treatment can be instituted.
We demonstrated blood brain barrier leakage associated with fetal alcohol spectrum disorder using two-photon microscopy. Evaluation was enhanced by concurrent imaging different conjugated dyes and second harmonic generation of collagen.