A5100355904- Cardiac Fibrosis and Remodeling
- Signaling Pathways in Disease
- Cardiac pacing and defibrillation studies
- Congenital heart defects research
- Lipoproteins and Cardiovascular Health
- Cardiac Imaging and Diagnostics
- Cardiovascular Health and Risk Factors
- Cardiac Structural Anomalies and Repair
- Lipid metabolism and disorders
- GDF15 and Related Biomarkers
- Atrial Fibrillation Management and Outcomes
- Neonatal Respiratory Health Research
- Heart Rate Variability and Autonomic Control
- Silymarin and Mushroom Poisoning
- PI3K/AKT/mTOR signaling in cancer
- Cytokine Signaling Pathways and Interactions
- Tissue Engineering and Regenerative Medicine
- Coronary Interventions and Diagnostics
- Respiratory Support and Mechanisms
- Pulmonary Hypertension Research and Treatments
- Angiogenesis and VEGF in Cancer
- Cardiac Health and Mental Health
- Platelet Disorders and Treatments
- Extracellular vesicles in disease
- Pain Mechanisms and Treatments
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2021-2024
Xuzhou Medical College
2024
Beijing Tian Tan Hospital
2022
Shandong University of Traditional Chinese Medicine
2017-2021
Harbin Medical University
2019-2021
First Affiliated Hospital of Harbin Medical University
2021
First Hospital of China Medical University
2020
China Medical University
2020
Linyi People's Hospital
2019
Second Affiliated Hospital of Harbin Medical University
2019
To explore the risk factors for in-stent restenosis (ISR) after stent implantation in patients with coronary heart disease (CHD) using logistic regression analysis. From February 2020 to 2022, 350 CHD percutaneous intervention (PCI) were divided into a stenosis group and nonstenosis based on angiography results performed 2 years PCI. Univariate multivariate regressions used analyze related ISR CHD. This study was approved by Ethics Committee of Shandong University Traditional Chinese...
Myocardial fibrosis (MF) is an essential pathological factor for heart failure. Previous studies have shown that the combination of Carthamus tinctorius L. and Lepidium apetalum Willd. (C-L), two types Chinese herbal medicine, can ameliorate MF after myocardial infarction (MI) in rats inhibit activation fibroblasts. However, mechanism C-L treatment remains unclear.A rat model with left anterior descending coronary ligation-induced MI was first established. Then, effects on cardiac function,...
Background: To study the effect of miR-29b on myocardial infarction via Notch signaling pathway in rats. Methods: The rat acute (AMI) models were established and divided into AMI group, sham group normal (N = 10 each group). HE (Hemotoxylin eosin) staining was used to detect whether model constructed successfully. MiR-29b mimics, inhibitors, mimics negative control (NC) transfected H9c2 (2-1) cells. Then, cells a inhibitor NC blank group. relative expression levels miR-29b, Notch1, DII4 Hesl...
The present study aimed to investigate the effect of C-type natriuretic peptide (CNP) on function cardiac fibroblasts (CFs). Western blotting was used expression myofibroblast marker proteins: α-smooth muscle actin (α-SMA), extra domain-A fibronectin, collagen I and III, activity extracellular signal-regulated kinase 1/2 (ERK1/2). Immunofluorescence examine morphological changes; a transwell assay analyze migration, reverse transcription-quantitative polymerase chain reaction ELISA were...
BackgroundThe objective of the current study was to molecular mechanism(s) underlying cardiac troponin I autoantibody (cTnIAAb) binding cardiomyocyte and resultant myocardial damage/dysfunction.MethodscTnIAAb purified from serum 10 acute infarction (AMI) patients with left ventricular remodeling. Recombinant human cTnI used generate three mouse-derived monoclonal anti-cTnI antibodies (cTnImAb1, cTnImAb2, cTnImAb3). The target proteins in myocyte membrane bound cTnImAb effect cTnIAAb on...
Abstract Thrombopoietin (TPO) is a haematopoietic cytokine mainly produced by the liver and kidneys, which stimulates production maturation of megakaryocytes. In past decade, numerous studies have investigated effects TPO outside system; however, role in progression solid cancer, particularly lung has not been well studied. Exogenous does affect non‐small‐cell cancer (NSCLC) cells as these show no or extremely low receptor expression; therefore, this study, we focused on endogenous NSCLC...
A multidirectional relationship has been demonstrated between myocardial infarction (MI) and depression. However, the causal genetic factors molecular mechanisms underlying this interaction remain unclear. The main purpose of study was to identify potential candidate genes for two diseases. Using a bioinformatics approach existing gene expression data in biomedical discovery support system (BITOLA), we defined starting concept X as "Myocardial Infarction" end Z "Major Depressive Disorder" or...
Abstract Coronary reperfusion following myocardial ischemia can lead to ischemia-reperfusion injury (MIRI).Ccr2 + macrophages play a pivotal role in MIRI, engaging not only acute inflammatory responses but also the formation of cardiac fibrosis. The mechanisms underlying latter are yet fully elucidated.This study aims explore mechanism by which this macrophage subgroup promotes fibrosis after MIRI through bioinformatics analysis Ccr2 and identify more molecular markers for MIRI. We sourced...
Introduction Non-valvular atrial fibrillation (NVAF) is a high-risk factor for ischaemic stroke. The 2016 European Society of Cardiology Atrial Fibrillation Management guidelines recommend oral anticoagulants (OACs) to prevent stroke in men with CHA 2 DS -VASc scores ≥2 and women ≥3. However, patients high risk bleeding (HAS-BLED (Hypertension, Abnormal renal/liver function, Stroke, Bleeding history or predisposition, Labile international normalized ratio, Elderly (> 65 years),...
Objective To investigate the association between cumulative exposure blood to pressure (cum BP) and new-onset chronic kidney disease (CKD). Methods In this prospective cohort study, 101 510 employees of Kailuan Group receiving annual health examination during 2006 2007 were observed. The participants received second, third, fourth examinations 2008 2009, 2010 2011, 2012 2013 year respectively. Their urinary serum creatinine tested, with incomplete SBP, DBP data CKD excluded. Further...