A5100418858- Pharmacological Effects of Natural Compounds
- Ginseng Biological Effects and Applications
- Phytochemistry and Bioactivity Studies
- Phytochemistry and biological activity of medicinal plants
- Advancements in Transdermal Drug Delivery
- Natural product bioactivities and synthesis
- Pharmacogenetics and Drug Metabolism
- Plant-based Medicinal Research
- Ginger and Zingiberaceae research
- melanin and skin pigmentation
- Hormonal Regulation and Hypertension
- Vitamin C and Antioxidants Research
- Biochemical Analysis and Sensing Techniques
- Chemical Reactions and Isotopes
- Microbial Metabolism and Applications
- Bioactive Compounds and Antitumor Agents
- Dermatology and Skin Diseases
- Helicobacter pylori-related gastroenterology studies
- Lipid metabolism and disorders
- Herbal Medicine Research Studies
- Acne and Rosacea Treatments and Effects
- Medicinal Plants and Bioactive Compounds
- Chemotherapy-induced cardiotoxicity and mitigation
- Liver Disease Diagnosis and Treatment
- Forensic Toxicology and Drug Analysis
Southern Medical University
2008-2024
China Pharmaceutical University
2014-2024
Nanjing University of Chinese Medicine
2024
Jiangsu Province Hospital
2024
Changchun University of Chinese Medicine
2023
Xinjiang Academy of Agricultural and Reclamation Science
2022
Chongqing Medical University
2022
Wayne State University
2019-2020
Child Guidance Center
2020
Yantai University
2020
Licorice flavonoid (LF) is the main component of Glycyrrhizae Radix et Rhizoma, a "medicine food homology" herbal medicine, which has anti-digestive ulcer activity, but mechanism in anti-gastric (GU) remains to be elucidated. In this study, we manifested that LF increased viability human gastric mucosal epithelial (GES-1) cells, attenuated ethanol (EtOH)-induced manifestations, reduced histological injury, suppressed inflammation, and restored barrier GU rats. After therapy, EtOH-induced gut...
Glycyrrhiza uralensis contains many secondary metabolites with a wide range of pharmacological activities. Drought stress acts as positive regulator to stimulate the production medicinal active component in G. uralensis, however, underlying mechanism remains unclear. The aim this work is investigate accumulation and regulatory pharmaceutical ingredients under drought stress. materials aerial underground parts seedlings treated by 10% PEG6000 for 0, 2, 6, 12, 24 h were used RNA sequencing...
Abstract Licorice flavonoids (LCFs) have been widely used in food care and medical treatment due to their significant antioxidant activities. However, the molecular mechanism of activity remains unclear. Therefore, network pharmacology, ADMET, density functional theory (DFT), docking, dynamics (MD) simulation were employed explore effects LCF. The pharmacology ADMET studies showed that active molecules kumatakenin (p K a = 6.18), licoflavonol 6.86), topazolin 6.21) LCF are key components...
Excessive oxygen free radicals can lead to aging, cancer, and other diseases. Therefore, searching for effective antioxidants scavenge has become the focus of modern medicine. In this study, molecular mechanism Licorice Green Tea Beverage (LGTB) in scavenging was investigated by means network pharmacology, docking experimental verification. Network pharmacology studies have shown that paeonol, eugenol, cinnamaldehyde, swertisin, rutin, glycyrrhetinic acid, oleic, pelargonidin-3-O-glucoside...
Licorice flavonoids (LCFs) are natural isolated from Glycyrrhiza which known to have anti-melanoma activities in vitro. However, the molecular mechanism of LCF has not been fully understood. In this study, network pharmacology, 3D/2D-QSAR, docking, and dynamics (MD) simulation were used explore anti-melanoma. First all, we screened key active components targets by pharmacology. Then, logIC50 values top 20 compounds predicted 2D-QSAR pharmacophore model, seven highly successfully. An optimal...
The purpose of the present study was to investigate cardioprotective effects Glycyrrhiza uralensis extract (GUE) against doxorubicin (DOX)-induced cardiotoxicity. Imprinting control region (ICR) mice were treated with saline, DOX (20 mg/kg intraperitoneal [ip] for once), GUE (100 intragastric [ig] 8 days), co-treatments and ig amifostine intravenous [iv] respectively. Serum levels lactate dehydrogenase (LDH) creatine kinase isoenzyme (CK-MB), glutathione peroxidase (GSH-P X ) activity, (GSH)...
We applied a label-free proteomic method to explore the mechanisms of Licorice flavonoid anti-acne effects in rat. Acne model was established back rats as group (MDL), then treated with licorice (LCF), while none control groups (CTR). In MDL, 314 differentially expressed proteins (DEPs) and 27 significantly (SDEPs) were identified compared what CTR. While LCF, 359 DEPs 15 SDEPs comparison MDL. Bioinformatics analysis showed that pathways related metabolism, tight junction, PI3K-Akt...
The present study was to systematically evaluate different licorice flavonoids (LFs) compounds release behaviors from the single payload hydrogel and LFs extracts hydrogels based on drug solubility in medium (DSRM), intermolecular strength of "release steric hindrance" (RSH). Two kinds (LFs 1: 2 = 5:1, W/W) were prepared with Carbopol 940 (CBP) as thickener, ten according actual content 1 extracts. mechanisms confirmed by vitro experiments molecular dynamic simulation analysis, evaluated...
Purpose: To test how glycyrrhizin (GLY) affects mouse corneal epithelial cells (MCEC) and the diabetic murine cornea. Methods: Viability of MCEC grown under normal or high glucose (HG) with/without GLY was tested by an MTT assay. In addition, C57BL/6 mice were injected with streptozotocin a subset control received in their drinking water. mRNA protein levels proinflammatory oxidative stress molecules reverse transcription-polymerase chain reaction (RT-PCR) both models. Ex vivo studies using...
The dynamic drug release mechanisms from Carbomer 940 (CP) hydrogels have not been systematically explored elsewhere. This study aimed to investigate the quantitative structure-activity relationship of licorice flavonoids (LFs) compounds on their CP based LFs-CP interactions and solubility in medium. Ten were formulated, vitro was conducted. intermolecular forces systems characterized by FTIR, molecular docking simulation. LFs classified into I (high-release capability) II (low-release...
Skeletal muscle wasting and weakness with mitochondrial dysfunction (MD) are major pathological problems in burn injury (BI) patients. Fibrinogen levels elevated plasma is an accepted risk factor for poor prognosis many human diseases, also designated one of damage-associated molecular pattern (DAMPs) proteins. The roles upregulated fibrinogen on changes critical illness including BI unknown. hypothesis tested was that BI-upregulated plays a pivotal role the inflammatory responses MD...
Abstract Objective: Mume fructus is commonly used in traditional Chinese medicine to treat nocturnal asthma symptoms. However, the molecular mechanisms underlying its effects on have not yet been established. This study evaluated therapeutic of treating asthma. Materials and Methods: Network pharmacology was investigate chemical composition, critical targets, potential action “ ” “nocturnal asthma” were as keywords search relevant databases. The 16HBE RAW264.7 cells treated with various...