A5101575989- Pharmacological Effects of Natural Compounds
- Phytochemistry and Bioactivity Studies
- Dyeing and Modifying Textile Fibers
- Spectroscopy and Quantum Chemical Studies
- Advancements in Transdermal Drug Delivery
- Ginseng Biological Effects and Applications
- Protein Structure and Dynamics
- Acne and Rosacea Treatments and Effects
- Crystallization and Solubility Studies
- Click Chemistry and Applications
- Phytochemicals and Antioxidant Activities
- melanin and skin pigmentation
- Dermatology and Skin Diseases
- Phytochemistry and biological activity of medicinal plants
- Drug Solubulity and Delivery Systems
- Free Radicals and Antioxidants
- Mass Spectrometry Techniques and Applications
- Silk-based biomaterials and applications
- Railway Systems and Energy Efficiency
- Crystallography and molecular interactions
- Skin Protection and Aging
- Electrical Contact Performance and Analysis
- Tunneling and Rock Mechanics
- Analytical Chemistry and Chromatography
- Railway Engineering and Dynamics
Southern Medical University
2022-2024
Swansea University
2023
BOE Technology Group (China)
2023
Aviation Industry Corporation of China (China)
2023
TCM-Intigrated Cancer Center of Southern Medical University
2023
Hubei University of Chinese Medicine
2020-2022
Southeast University
2021-2022
Southwest Jiaotong University
2017-2019
Institute of High Energy Physics
2018
Chinese Academy of Sciences
2018
Abstract Bacterial infections and inflammation progression yield huge trouble for the management of serious skin wounds burns. However, some hydrogel dressing exhibit poor wound‐healing capabilities. Additionally, little information is given on molecular theory gelation mechanisms drug release performance from drug‐polymer network in water environment. Herein, cationic guar gum (CG) first mixed with dipotassium glycyrrhizinate (DG), then crosslinked Cu 2+ to strengthen mechanical strength...
Initiation of protein folding by light can dramatically improve the time resolution kinetic studies. Here we present an example optically triggered reaction using nanosecond photodissociation heme-carbon monoxide complex reduced cytochrome c. The optical trigger is based on observation that under destabilizing conditions c be unfolded preferential binding carbon to covalently attached heme group in state. Photodissociation thus triggers reaction. We used time-resolved absorption spectroscopy...
An ultrarapid-mixing continuous-flow method has been developed to study submillisecond folding of chemically denatured proteins. Turbulent flow created by pumping solutions through a small gap dilutes the denaturant in tens microseconds. We have used this cytochrome c kinetics previously inaccessible time range 80 μs 3 ms. To eliminate heme–ligand exchange chemistry that complicates and slows trapping misfolded structures, measurements were made with imidazole complex. Fluorescence quenching...
Licorice flavonoid (LF) is the main component of Glycyrrhizae Radix et Rhizoma, a "medicine food homology" herbal medicine, which has anti-digestive ulcer activity, but mechanism in anti-gastric (GU) remains to be elucidated. In this study, we manifested that LF increased viability human gastric mucosal epithelial (GES-1) cells, attenuated ethanol (EtOH)-induced manifestations, reduced histological injury, suppressed inflammation, and restored barrier GU rats. After therapy, EtOH-induced gut...
This study aimed to systematically compare licochalcone A (LicA) and glabridin (Gla) (whitening agents) release permeation from Carbomer 940 (CP) hydrogels with different enhancers, evaluate the relationship between quantitative enhancement efficacy structures of enhancers. An in vitro an experiment solution using porcine skin were performed. We found that Gla-CP hydrogel showed a higher drug retention amount than LicA-CP due solubility medium better miscibility Gla LicA. Enhancers molecular...
Abstract Eutectogels, a family of emerging materials, integrate the characteristics deep eutectic solvents (DES) and gels, presenting unique application potential in biomedical engineering. However, latest progress eutectogels their applications field remain to be summarized refined. This review first introduces composition properties generated by interaction between DES gel matrix. Subsequently, classifications advantages are comprehensively discussed according cross‐linked preparation...
Acne vulgaris is one of the most common inflammatory dermatoses in dermatological practice and can affect any gender or ethnic group. Although previous studies, we had found that licorice flavonoids (LCF) play an anti-acne role by inhibiting PI3K-Akt signaling pathways mitochondrial activity, mechanism LCF regulating skin metabolism, serum metabolism microbes still unclear. Here, performed a full spectrum analysis metabolites using UHPLC-Triple TOF-MS. The results showed could treat acne...
Abstract Licorice flavonoids (LCFs) have been widely used in food care and medical treatment due to their significant antioxidant activities. However, the molecular mechanism of activity remains unclear. Therefore, network pharmacology, ADMET, density functional theory (DFT), docking, dynamics (MD) simulation were employed explore effects LCF. The pharmacology ADMET studies showed that active molecules kumatakenin (p K a = 6.18), licoflavonol 6.86), topazolin 6.21) LCF are key components...
Currently, the detection equipment for offline arcing on high-speed trains is of great interest because it can evacuate contact state between wire and strip. In order to ensure safety train under effect arcing, self-designed fourth-order Hilbert curve fractal antenna chosen detect in this paper, based its electromagnetic radiation signal. Aspects time-, frequency-, joint time-frequency-domain analyses signals were considered. Meanwhile, experiments conducted several times with different...
Excessive oxygen free radicals can lead to aging, cancer, and other diseases. Therefore, searching for effective antioxidants scavenge has become the focus of modern medicine. In this study, molecular mechanism Licorice Green Tea Beverage (LGTB) in scavenging was investigated by means network pharmacology, docking experimental verification. Network pharmacology studies have shown that paeonol, eugenol, cinnamaldehyde, swertisin, rutin, glycyrrhetinic acid, oleic, pelargonidin-3-O-glucoside...