A5115695535- Advanced Fiber Optic Sensors
- Drilling and Well Engineering
- Rock Mechanics and Modeling
- Remote Sensing and LiDAR Applications
- Osteoarthritis Treatment and Mechanisms
- Photonic Crystal and Fiber Optics
- Remote Sensing and Land Use
- Fungal Biology and Applications
- Infrastructure Maintenance and Monitoring
- Dielectric properties of ceramics
- Fluorine in Organic Chemistry
- Ferroptosis and cancer prognosis
- Particle physics theoretical and experimental studies
- Tunneling and Rock Mechanics
- Radiomics and Machine Learning in Medical Imaging
- Gestational Diabetes Research and Management
- Mercury impact and mitigation studies
- Catalytic Processes in Materials Science
- Hydraulic Fracturing and Reservoir Analysis
- Musculoskeletal pain and rehabilitation
- Structural Behavior of Reinforced Concrete
- Enhanced Oil Recovery Techniques
- Advanced Nanomaterials in Catalysis
- Phytochemistry and Bioactivity Studies
- Pregnancy-related medical research
Nantong University
2025
Nanjing Drum Tower Hospital
2020-2025
National Clinical Research Center for Digestive Diseases
2025
Zhejiang University
2025
Eighth Affiliated Hospital of Sun Yat-sen University
2023-2025
Sun Yat-sen University
2023-2025
City University of Hong Kong
2023-2025
Duke Kunshan University
2025
City University of Hong Kong, Shenzhen Research Institute
2025
Chinese Academy of Social Sciences
2024
Despite the great success achieved by photoactivated chemotherapy, eradicating deep tumors using external sources with high tissue penetration depth remains a challenge. Here, we present cyaninplatin, paradigm of Pt(IV) anticancer prodrug that can be activated ultrasound in precise and spatiotemporally controllable manner. Upon sono-activation, mitochondria-accumulated cyaninplatin exhibits strengthened mitochondrial DNA damage cell killing efficiency, overcomes drug resistance as...
RNA interference (RNAi) and oxidative stress inhibition therapeutic strategies have been extensively utilized in the treatment of osteoarthritis (OA), most prevalent degenerative joint disease. However, synergistic effects these approaches on attenuating OA progression remain largely unexplored. In this study, matrix metalloproteinase-13 siRNA (siMMP-13) was incorporated onto polyethylenimine (PEI)-polyethylene glycol (PEG) modified Fe3O4 nanoparticles, forming a nucleic acid nanocarrier...
The concept of in situ 3D bio-printing was previously reported, while its realization has still encountered with several difficulties. present study aimed to report robotic-assisted technology for cartilage regeneration, and explore potential clinical application. A six-degree-of-freedom (6-DOF) robot introduced this study, a fast tool center point (TCP) calibration method developed improve printing accuracy. bio-ink consisted hyaluronic acid methacrylate acrylate-terminated 4-armed...
We experimentally and computationally analyze impact-shock-induced stress wave propagation in packings of disordered flexible fibers. find that dispersive propagation, associated with large attenuation, occurs much more prevalently systems larger fiber aspect ratios moderate flexibility. trace these features to the microstructural properties contact chains energy-trapping abilities deformable These findings provide insights into physics shock-impacted open way toward an improved...
Abstract Previous research has identified a variety of factors that contribute to the development and maintenance wounds. Concurrently, electroacupuncture been demonstrated facilitate wound healing. However, effects transcutaneous electrical acustimulation (TEA) on healing, as well its relationship with key such Wnt3a, TGF-β, Akt, c-Myc, VEGF-A, SP1, nitric oxide (NO), mitochondrial function, remain largely unexplored. We hypothesize TEA will activate signaling enhance functions promote...
The interplay between lipid droplets (LDs) and endosomes remains unknown. Here, we screen synthesize AP1-coumarin, an LD-specific probe, by conjugating a fluorescent dye coumarin to triazine compound AP1. AP1-coumarin labels all stages of LDs in live cells markedly induces the accumulation enlarged RAB5-RAB7 double-positive intermediate endosomes. AP1-coumarin-labeled contact these endosomes, with some even being engulfed them. When LD biogenesis is inhibited, ability label reduced,...
Granular materials transition between unjammed (deformable) and jammed (rigid) states when adjusting their packing density. Here, we report on experiments demonstrating that the same kind of phase can be alternatively achieved through temperature-controlled particle shape change. Using a confined system randomly-packed rod-like particles made memory alloy (SMA), exploit recovery these bent rods with rising temperature at constant density leads to state. The responsible physical processes are...
Abstract Soil moisture is a key factor affecting crop growth and yield. Information on soil critical for monitoring yield estimation. This study evaluated the OPtical TRApezoid Model (OPTRAM) estimates in Sanjiang Plain, China, using Moderate Resolution Imaging Spectroradiometer (MODIS) data situ acquired from May to September 2016 2017. model was empirically calculated by parameterizing relationship between normalized difference vegetation index (NDVI) shortwave infrared transformed...
Abstract Sustained inflammatory invasion leads to joint damage and progressive disability in several autoimmune rheumatic diseases. In recent decades, targeting M1 macrophage polarization has been suggested as a promising therapeutic strategy for arthritis. P300/CBP-associated factor (PCAF) is histone acetyltransferase (HAT) that exhibits strong positive relationship with the proinflammatory microenvironment. However, whether PCAF mediates remains poorly studied, can protect against...
Background Mushrooms are considered as next-generation healthy food components. Owing to their low-fat content, high-quality proteins, dietary fiber, and rich source of nutraceuticals. They ideally preferred in formulation low-caloric functional foods. In this view, the breeding strategies mushroom Auricularia cornea ( A. ) focusing on high yield higher quality with nutritional values health benefits still needed. Materials methods A total 50 strains were used analyze bio efficiency time...
The rapid development of urbanization has led to a continuous rise in number elevators. This elevator failures from time time. At present, although there are some studies on fault diagnosis, they more or less limited by the lack data make research superficial. For such complex special equipment as elevator, it is difficult obtain reliable and sufficient train diagnosis model. To address this issue, paper first establishes numerical model vertical vibration for elevators with three degrees...
Abstract Background Intervertebral disc degeneration (IDD) is one of the most common disorders related to spine. Inflammation, apoptosis and extracellular matrix (ECM) degradation contribute in nucleus pulposus cells (NPCs). This study focused on role mechanism p38 inhibitor TAK-715 intervertebral degeneration. Methods NPCs were treated with IL-1β mimic apoptosis, followed by addition TAK-715. It was determined that inflammatory mediators (COX-2), cytokines (HMGB1), ECM components (collagen...
Ankylosing spondylitis (AS) is a common rheumatic disorder distinguished by chronic inflammation and heterotopic ossification at local entheses sites. Currently available medications, including nonsteroidal anti-inflammatory drugs (NSAIDs), disease-modifying anti-rheumatic (DMARDs) TNF inhibitors, are limited side effects, high costs unclear inhibitory effects on ossification. Herein, we developed manganese ferrite nanoparticles modified the aptamer CH6 (CH6-MF NPs) that can efficiently...