A5084543273- Respiratory viral infections research
- Influenza Virus Research Studies
- Poxvirus research and outbreaks
- Bacillus and Francisella bacterial research
- Pneumonia and Respiratory Infections
- Virus-based gene therapy research
- Rabies epidemiology and control
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Fungal Infections and Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Infectious Encephalopathies and Encephalitis
- Viral Infections and Immunology Research
- Travel-related health issues
- Streptococcal Infections and Treatments
- Advanced Chemical Sensor Technologies
- Aortic aneurysm repair treatments
- Immunodeficiency and Autoimmune Disorders
- Antibiotic Use and Resistance
- Parvovirus B19 Infection Studies
- HIV/AIDS Research and Interventions
- Vaccine Coverage and Hesitancy
- Child and Adolescent Psychosocial and Emotional Development
- Viral Infections and Vectors
- Eosinophilic Esophagitis
Bruker (United States)
2025
Bruker (Switzerland)
2024
The University of Texas Health Science Center at San Antonio
2023-2024
South Texas Veterans Health Care System
2019-2024
Nanostring Technologies (United States)
2023
United States Air Force
2005-2022
Brooke Army Medical Center
2014-2021
Wilford Hall Ambulatory Surgical Center
2017-2021
David Grant USAF Medical Center
2005-2019
Harborview Medical Center
2018
To develop content validity of a comprehensive patient-reported outcome (PRO) measure following current best scientific methodology to standardize assessment influenza (flu) symptoms in clinical research. Stage I (Concept Elicitation): 1:1 telephone interviews with influenza-positive adults (≥18 years) the US and Mexico within 7 days diagnosis. Participants described symptom type, character, severity, duration. Content analysis identified themes developed draft Flu-PRO instrument. II...
Abstract Some people remain healthier throughout life than others but the underlying reasons are poorly understood. Here we hypothesize this advantage is attributable in part to optimal immune resilience (IR), defined as capacity preserve and/or rapidly restore functions that promote disease resistance (immunocompetence) and control inflammation infectious diseases well other causes of inflammatory stress. We gauge IR levels with two distinct peripheral blood metrics quantify balance between...
The inFLUenza Patient Reported Outcome (FLU-PRO) measure is a daily diary assessing signs/symptoms of influenza across six body systems: Nose, Throat, Eyes, Chest/Respiratory, Gastrointestinal, Body/Systemic, developed and tested in adults with influenza.
The risk of severe coronavirus disease 2019 (COVID-19) varies significantly among persons similar age and is higher in males. Age-independent, sex-biased differences susceptibility to COVID-19 may be ascribable deficits a sexually dimorphic protective attribute that we termed immunologic resilience (IR).
Viral infections cause increased oxidative stress, so a breath test for stress biomarkers (alkanes and alkane derivatives) might provide new tool early diagnosis. We studied 33 normal healthy human subjects receiving scheduled treatment with live attenuated influenza vaccine (LAIV). Each subject was his or her own control, since they were on day 0 prior to vaccination, then days 2, 7 14 following vaccination. Breath volatile organic compounds (VOCs) collected collection apparatus, analyzed...
Providers are central to effective implementation of HIV pre-exposure prophylaxis (PrEP). Primary care providers (PCP) and infectious disease physicians (ID) in the US Air Force (USAF) participated a cross-sectional survey regarding knowledge, attitudes, beliefs toward PrEP. Characteristics associated with PrEP knowledge were assessed univariate multivariate analyses. Among 403 (40% 1015 providers) participants, 9% (PCP 383, ID 20) ever prescribed In analysis, years practice, number...
Abstract Estrogen receptor (ER) positive luminal early breast cancer (BC) benefits from endocrine therapy based on the selective ER modulator tamoxifen (TAM) and aromatase inhibitors (AI). Yet, tumor recurrence occurs in up to one third of patients due primary secondary treatment resistance (ETR). The causes ETR are not well defined by predictive markers, however, TP53 mutations have been linked with a preoperative short-term study. We used previously learned mutation-predictive p53 score as...
Bacillary angiomatosis is a rare cutaneous manifestation caused by infection with Bartonella henselae that most often seen in immunocompromised individuals, particularly those HIV. We present an HIV-negative elderly man bacillary unexplained pancytopenia. The patient presented solitary, pedunculated, vascular nodule on his right forearm, and shave biopsy was performed to rule out metastatic cancer. Biopsy results were consistent angiomatosis, which confirmed polymerase chain reaction....
Abstract Skin squamous cell carcinoma (SCC) is characterized by heterogeneity in differentiation states and immune exclusion within the tumor microenvironment (TME). Using Bruker Spatial Biology CosMx® Whole Transcriptome (WTX) panel, which profiles approximately 19, 000 genes at single-cell resolution, we examined spatial gene expression FFPE SCC sections. Individual single boundaries were defined utilizing a trained AI segmentation model. H&E staining on same tissue provided...
Lung cancer, the leading cause of cancer-related deaths worldwide, primarily consists non-small cell lung cancer (NSCLC), including subtypes like adenocarcinoma (LUAD) and squamous carcinoma (LUSC). These exhibit distinct histopathological features but share overlapping molecular characteristics. Understanding spatial heterogeneity these tumors is critical for identifying novel biomarkers therapeutic targets. This study utilizes CosMx® Spatial Molecular Imager (SMI) platform to profile LUAD...
A female patient with atopic dermatitis who had recently received a tattoo presented severe right ear pain and several vesiculopustular lesions. Over 1 week, she developed approximately 80 widely distributed Laboratory testing confirmed mpox (previously monkeypox) virus, no further lesions after initiation of oral tecovirimat.
Large numbers of armed forces personnel returning from southwest Asia may present with infections that are not endemic to the United States or occur rarely and underdiagnosed in States. We report 2 cases acute Q fever members US Military recently returned Iraq. Because a number recent reports suggest risk be higher than initially thought among deployed this region, clinicians need have high index clinical suspicion, an understanding available diagnostic tests, knowledge regarding methodology...
Iatrogenic Cushing syndrome with secondary adrenal insufficiency is a rare but recognized complication of intra-articular corticosteroid injection. Recent reports suggest that the risk this serious significantly higher in human immunodeficiency virus (HIV)-infected patients receiving ritonavir-based antiretroviral regimens. This article describes case 44-year-old HIV-infected man taking ritonavir who required admission to intensive care unit (ICU) for hyperosmolar hyperglycemic state...
We describe a patient who developed dilated cardiomyopathy and clinical congestive heart failure after 2 months of therapy with amphotericin B (AmB) for disseminated coccidioidomycosis. His echocardiographic abnormalities resolved posaconazole was substituted AmB. It is important to recognize the rare potentially reversible toxicity
Human coronavirus (HCoV) is a known cause of influenza‐like illness (ILI). In multisite, observational, longitudinal study ILI among otherwise healthy adolescents and adults, 12% subjects were PCR‐positive for HCoV. The distribution species was as follows: HCoV‐OC43 (34%), HCoV‐229E (28%), HCoV‐NL63 (22%), HCoV‐HKU1 (16%). We did not observe species‐specific differences in the clinical characteristics HCoV infection, with exception HCoV‐HKU1, which severity gastrointestinal symptoms trended...
Objective The objectives of this study were to describe the epidemiology HIV in United States Air Force (USAF) from 1996 through 2011 and assess whether socio-demographic characteristics service-related mobility, including military deployments, associated with infection. Methods We conducted a retrospective cohort analysis USAF personnel who HIV-infected during period January 1, December 31, matched case-control study. Cases newly-diagnosed period. Five randomly-selected HIV-uninfected...
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Single-cell RNA-seq revolutionized single-cell biology, by providing a complete whole transcriptome view of individual cells. Regrettably, this was accomplished only for individual, tissue-dissociated High-plex spatial biology has begun to recover the x, y, and z-coordinates single-cells, but typically at expense far less than coverage. To solve problem, Bruker Spatial Biology commercial-grade panel (CosMx® Molecular Imager Whole Transcriptome Panel (WTx)), using 37,872 imaging barcodes,...
Volatile organic compounds (VOCs) are produced systemically due to varied physiological states such as oxidative stress and excreted through the lungs. Benchtop preliminary clinical data suggest that breath testing may be a useful diagnostic modality for viral respiratory tract infections.Patients with influenza-like illness (ILI) presenting single clinic in San Antonio, Texas, from 3/2017 3/2019 submitted 2-minute sample addition nasopharyngeal swab collected polymerase chain reaction (PCR)...
Septic arthritis is a serious, life and limb threatening infection. If suspected, empiric treatment must begin immediately account for the most likely pathogens. Eight days following left knee arthroscopic surgery, 51-year-old active duty male spent approximately 1 hour driving personal watercraft on Okaloosa Bay near Gulf of Mexico. later, he presented to emergency room with septic that knee. Fluid aspirated from joint yielded Aeromonas hydrophila. The infection resolved surgical drainage...