A5004567569- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- SARS-CoV-2 and COVID-19 Research
- Polyomavirus and related diseases
- Mycobacterium research and diagnosis
- Gut microbiota and health
- Autoimmune and Inflammatory Disorders Research
- Cerebral Palsy and Movement Disorders
- Systemic Sclerosis and Related Diseases
- Amyotrophic Lateral Sclerosis Research
- Effects of Vibration on Health
- Ginseng Biological Effects and Applications
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Neurogenetic and Muscular Disorders Research
- Parkinson's Disease Mechanisms and Treatments
- RNA Research and Splicing
- Neurological disorders and treatments
- Advanced Differential Geometry Research
- Long-Term Effects of COVID-19
- Fatigue and fracture mechanics
- Evolution and Genetic Dynamics
- Family and Disability Support Research
- Adolescent and Pediatric Healthcare
- Genetics and Neurodevelopmental Disorders
University of Sassari
2015-2024
Azienda Ospedaliero Universitaria di Sassari
2021-2024
University of Genoa
2020
Aim: In this single blind randomized controlled trial, we examined the effect of a virtual reality-based training on gait people with multiple sclerosis.Methods: Twenty-five individuals sclerosis mild to moderate disability were randomly assigned either control group (n = 11) or experimental 14). The subjects in received treadmill training. Subjects reality based Clinical measures and parameters evaluated.Result: both groups significantly improved walking endurance speed, cadence stride...
Objectives Vaccination against COVID-19 is highly recommended to patients affected by multiple sclerosis (MS); however, the impact of MS disease-modifying therapies (DMTs) on immune response following vaccination has been only partially investigated. Here, we aimed elucidate effect DMTs humoral mRNA-based anti-SARS-CoV-2 vaccines in patients. Methods We obtained sera from 912 Sardinian and 63 healthy controls 30 days after second dose BNT162b2 vaccine tested them for SARS-CoV-2 using...
To assess whether the presence of concomitant diseases at multiple sclerosis (MS) diagnosis is associated with choice and treatment persistence in an Italian MS cohort.We included newly diagnosed patients (2010-2016) followed 20 centers collected demographic clinical data. We evaluated baseline factors related to comorbidities association between course time first switch.The study cohort 2,076 patients. Data on were available for 1,877/2,076 (90.4%). A total 449/1,877 (23.9%) had least 1...
Background: With many options now available, first therapy choice is challenging in multiple sclerosis (MS) and depends mainly on neurologist patient preferences. Objectives: To identify prognostic factors for early switch after choice. Methods: Newly diagnosed relapsing–remitting MS patients from 24 Italian centers were included. We evaluated the association of baseline demographics, clinical, magnetic resonance imaging (MRI) data to probability lack efficacy or intolerance/safety with a...
<h3>Objective</h3> Cladribine tablets were tested against placebo in randomized controlled trials (RCTs). In this study, the effectiveness of cladribine vs other approved drugs patients with relapsing-remitting MS (RRMS) was compared by matching RCT to observational data. <h3>Methods</h3> Data from pivotal trial assessing (CLARITY) propensity score matched data Italian multicenter database i-MuST. This included 3,150 diagnosed between 2010 and 2018 at 24 centers who started a...
Human endogenous retrovirus (HERV)-K env-su glycoprotein has been documented in amyotrophic lateral sclerosis (ALS), where HERV-K 19–37 antibody levels significantly correlated with clinical measures of disease severity. Herein, we investigated further the humoral and cell-mediated immune response against specific antigenic peptides derived from ALS. env expression on peripheral blood mononuclear cells (PBMCs) membrane cytokines chemokines after stimulation 109–126 were quantified patients...
The contralateral strength training (CST) effect is a transfer of muscle performance to the untrained limb following side.The aim this study was explore, in individuals with multiple sclerosis (MS) presenting marked lower asymmetry, effectiveness CST on management weakness more-affected less-affected limb.A single-subject research design used.Eight MS underwent 16 18 high-intensity sessions ankle dorsiflexor muscles. primary outcome measure single-system case series maximal expressed as peak...
Background: Personality traits can affect health-related quality of life (HRQoL) in different disorders. In multiple sclerosis (MS), personality determine patients’ willingness to take on more risky treatment options, predispose neuropsychiatric symptoms and coping strategies. Objectives: We investigated the role as possible predictors HRQoL a large cohort persons with MS (PwMS). Methods: total, 253 consecutively recruited PwMS were screened for intellectual deficits Raven Colour Progressive...
The human endogenous retrovirus-K (HERV-K) and TAR DNA-binding protein 43 (TDP-43) have been associated with the pathophysiology of amyotrophic lateral sclerosis (ALS). Given these findings, we investigated humoral response against HERV-K envelope surface (env-su) glycoprotein antigens TDP-43 in plasma ALS patients healthy controls (HCs). measured levels Abs different epitopes' fragments were significantly elevated patients, both long-survivor (LS) newly diagnosed (ND) compared to HCs. We...
Abstract Objective Multiple sclerosis (MS) is a complex disorder in which environmental and genetic factors interact modifying disease risk course. This multicentre, case–control study involving 18 Italian MS Centres investigated course by ethnicity native-country economic status foreign-born patients living Italy. Methods We identified 457 who migrated to Italy 893 age- sex-matched native-born patients. In our population, 1225 (93.2%) subjects were White Europeans Northern Americans (WENA)...
Childhood neurodevelopmental disorders (NDDs), including specific learning (SLD), attention deficit/hyperactivity disorder (ADHD) and autism spectrum (ASD), are pathogenically linked to familial autoimmunity maternal immune-mediated diseases during pregnancy.We studied MS as a potential risk factor for NDDs occurrence in offspring.MS control mothers were subjected questionnaires ascertain NDD diagnosis their progeny the of both autoimmune neurodevelopment families. Suspected cases evaluated...
ASD is a neurodevelopmental disorder of unknown aetiology but with known contribution pathogenic immune-mediated mechanisms. HERVs are associated several neuropsychiatric diseases, including ASD. We studied anti-HERV-W, -K and -H-env immune profiles in children to analyse differences between their respective mothers child/mother control pairs possible correlations severity loss adaptive abilities. Of the 84 individuals, 42 (23 19 neurotypical) paired underwent clinical neuropsychological...
Gait disturbances are common in multiple sclerosis (MS) subjects. In particular, a non-physiological reduction of the walking speed and an increase gait variability is observed during concurrent cognitive challenge task. Virtual reality (VR) allows delivery challenging environments to train MS individuals. This study aims investigate effects two types intensive treadmill-based interventions on The share same training protocol, except for use VR. Seventeen patients enrolled were randomized...
Abstract Background In gut ecosystems, there is a complex interplay of biotic and abiotic interactions that decide the overall fitness an individual. Divulging microbe-microbe microbe-host may lead to better strategies in disease management, as microbes rarely act isolation. Network inference for microbial communities often challenging task limited by both analytical assumptions well experimental approaches. Even after network topologies are obtained, identification important nodes within...
Multiple sclerosis (MS) is a demyelinating autoimmune disease characterized by early onset, for which the interaction of genetic and environmental factors crucial. Dysregulation immune system as well myelinization-de-myelinization has been shown to correlate with changes in RNA, including non-coding RNAs. Recently, circular RNAs (circRNAs) have emerged key player complex network gene dysregulation associated MS. Despite several efforts, mechanisms driving circRNA regulation MS still need be...
The microbial ecology of Mycobacterium avium subspecies paratuberculosis infections (MAP) within the context Multiple Sclerosis (MS) is largely an unexplored topic in literature. Thus, we have characterized compositional and predicted functional differences gut microbiome between MS patients with MAP (MAP+) without (MAP-) infection. This was done exposome (through self-reported filled questionnaires), principally anthropometric sociodemographic patterns to gain understanding dynamics. 16S...
Aim We assessed the frequency, characteristics, and future trajectory of monophasic acquired demyelinating syndromes (ADS) associated with conversion to paediatric multiple sclerosis. Method This was a retrospective observational study Sardinian children (<18y age) onset ADS between 2001 2018. Results identified 44 (21 males, 23 females; median age at 16y, range 4mo–18y), 21 whom were already presenting criteria for The mean crude prevalence in 59.2 per 100 000, while incidence 3.1 000...
Abstract Background and purpose The aim was to evaluate the risk of relapse after severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccination, its safety tolerability, in patients with chronic inflammatory neuropathies. Methods In this multicenter, cohort case‐crossover study, associated SARS‐CoV‐2 vaccination assessed by comparing frequency demyelinating polyradiculoneuropathy (CIDP) multifocal motor neuropathy (MMN) who underwent or did not undergo vaccination. Frequency 3...
Abstract Background There is a growing body of evidence suggesting the role gut microbiome in aetiology Multiple sclerosis (MS) with development and progression disease as multifactorial interaction between gut, brain, immune system. At same time there also existing to link Mycobacterium avium subspecies paratuberculosis infections (MAP) MS. Whilst perturbations patients MS are well described literature, nothing known about MAP infected patients. In present study, using 16S rRNA...