A5071400450- Carcinogens and Genotoxicity Assessment
- Viral Infections and Immunology Research
- Birth, Development, and Health
- Pesticide and Herbicide Environmental Studies
- Liver Disease Diagnosis and Treatment
- Chromosomal and Genetic Variations
- Diabetes and associated disorders
- Effects and risks of endocrine disrupting chemicals
- T-cell and B-cell Immunology
- Genetic Associations and Epidemiology
- Selenium in Biological Systems
- Cancer-related molecular mechanisms research
- Pharmaceutical and Antibiotic Environmental Impacts
- Parkinson's Disease Mechanisms and Treatments
- IL-33, ST2, and ILC Pathways
- Weed Control and Herbicide Applications
- Autism Spectrum Disorder Research
- Glutathione Transferases and Polymorphisms
- Adipokines, Inflammation, and Metabolic Diseases
- Genetics and Neurodevelopmental Disorders
- Tryptophan and brain disorders
- SARS-CoV-2 and COVID-19 Research
- Genetics, Aging, and Longevity in Model Organisms
- Animal Genetics and Reproduction
- melanin and skin pigmentation
University of Sassari
2021-2025
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2025
University of Turin
2018-2021
Accademia Albertina delle Belle Arti
2018
The envelope proteins syncytin-1 and pHERV-W from the Human Endogenous Retroviral family 'W' (HERV-W) have been identified as potential risk factors in multiple sclerosis (MS). This study aims to evaluate both humoral cell-mediated immune response antigenic peptides derived these across different clinical forms inflammatory phases of MS. Indirect enzyme-linked immunosorbent assay (ELISA) was employed measure immunoglobulin G (IgG) responses syncytin-1env 486-500 pHERV-Wenv 486-504 MS...
In this work, we observed an increased presence of antibodies (Abs) against type I interferon (IFN-I) in coronavirus disease 2019 (COVID-19) patients admitted to the intensive care unit (ICU) compared non-ICU COVID-19 and healthy control (HC) subjects. Human endogenous retrovirus W (HERV-W) can reactivate after viral infection; therefore, also investigated HERV-W envelope (HERV-W-env)-derived epitopes. A total 113 subjects (41 female 72 male subjects) were analyzed. significant difference...
Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn's (CD) irritable syndrome (IBS) are distinct gastrointestinal disorders. Mycobacterium avium subspecies paratuberculosis (MAP) is implicated in IBD pathogenesis, while the roles of human endogenous retroviruses (HERVs) under investigation. We aimed (a) to investigate whether levels humoral response MAP-3865c, HERV-K envelope HERV-W against epitopes IBD/IBS patients; (b) determine frequency micronuclei patients (c)...
A higher expression of human endogenous retroviruses (HERVs) has been associated with several malignancies, including prostate cancer, implying a possible use as diagnostic or prognostic cancer biomarker. For this reason, we examined the humoral response against different epitopes obtained from envelope protein HERV-K (HERV-K env-su19-37, env-su109-126), HERV-H (HERV-H env-su229-241, env387-399) and HERV-W (HERV-W env-su93-108, env-su248-262) in plasma patients affected by (PCa), compared to...
Abstract The role of retroviral envelope proteins belonging to the Human Endogenous Retroviral family ‘W’ (HERV‐W), specifically syncytin‐1 and pathogenic HERV‐W (pHERV‐W), as potential risk factors in multiple sclerosis (MS) has been established. This study aimed investigate humoral response pHERV‐W‐derived peptides a group relapsing remitting MS patients categorized having acute or stable disease. Furthermore, an inhibition assay was conducted assess extent cross‐reactivity between two...
Parkinson’s disease (PD) is a neurodegenerative disorder involving the accumulation of alpha-synuclein (α-syn)/Lewy bodies in brain and -enteric nervous system. The etiology not well understood, but bacterial viral infections may contribute to pathogenesis PD. It has been suggested that gastrointestinal (GI) complications observed PD patients arise from dysbiosis, leading curli/α-syn deposits enteric Enteric bacteria secrete curli, functional amyloid peptide involved adhesion surfaces, cell...
Oxybenzone or benzophenone-3 (2-hydroxy-4-methoxybenzophenone; BP-3) is a filter used in variety of personal care products for protection human skin and hair from damage by ultraviolet radiation. BP-3 suspected to exhibit endocrine disruptive properties. Indeed, it was found be able interact with the system causing alteration its homeostasis, consequent adverse health effects. Moreover, ubiquitously present environment, mostly aquatic ecosystems, risks organisms humans. In study, we analyzed...
The immune system plays a critical role in modulating cancer development and progression. Polymorphisms key genes involved responses are known to affect susceptibility cancer. Here, we analyzed 35 evaluate the association between variants of prostate risk. Thirty-five were 47 patients with 43 healthy controls using next-generation sequencing. Allelic genotype frequencies calculated both cohorts, generalized linear mixed model was applied test relationship risk nucleotide substitution. Odds...
Bisphenol A (BPA), a recognized endocrine-disrupting chemical, is used in the production of epoxy and polycarbonate resins. Since human exposure to BPA has been associated with increased cancer susceptibility, market shifted products often labeled as "BPA free" containing analogs such bisphenol F (BPF) S (BPS). However, European legislation on BPF BPS still unclear. This study analyzed effects BPA, BPF, peripheral blood mononuclear cells by using vitro micronucleus assay. Furthermore, it...
Human endogenous retroviruses (HERVs) have been thought of as silent passengers within our genomes, but their reactivation has linked with several autoimmune diseases, including type 1 diabetes (T1DM). In order to evaluate the potential role HERVs, in addition recognized HERV-W, we focused on debated HERV-K family T1DM. Therefore, performed a serological evaluation IgG antibodies against Env epitope (HERV-K Env19−37) comparison an important β-cellular autoimmunity biomarker, ZnT8, from...
ASD is a neurodevelopmental disorder of unknown aetiology but with known contribution pathogenic immune-mediated mechanisms. HERVs are associated several neuropsychiatric diseases, including ASD. We studied anti-HERV-W, -K and -H-env immune profiles in children to analyse differences between their respective mothers child/mother control pairs possible correlations severity loss adaptive abilities. Of the 84 individuals, 42 (23 19 neurotypical) paired underwent clinical neuropsychological...
Background: Longevity is considered the result of interactions between environmental and genetic factors.Aim: To investigate possible association body mass index frequencies APOE, ACE, eNOS FTO gene polymorphisms with longevity.Subjects methods: In total, 1100 healthy volunteers aged 10-100 were recruited. Subjects genotyped for polymorphisms. Data about height weight also collected. The sample was split into four age groups: 1-24, 25-49, 50-85 86-100 years.Results: Significant differences...
Abstract Longevity is a complex process controlled by both environmental and genetic factors. We evaluated the association of four cytokine gene polymorphisms with longevity in an Italian cohort. A sample 1019 subjects aged 10 to 100 belonging North‐Italian population was genotyped for IL‐6 (G>C, rs1800796), IL‐10 ‐1082 (G>A, rs1800896), TNF‐α ‐308 rs1800629), TGFβ1 codon (T>C, rs1800471) polymorphisms. The between dividing into age groups: 24, 25 49, 50 85, 86 100. observed...
Longevity is a complex process controlled by environmental and genetic factors. We evaluated the association of seven drug metabolising DNA-repair gene polymorphisms with longevity in an Italian cohort. A sample 756 subjects aged 18-98 was genotyped for CYP1A1 (rs1048943, A>G), GSTM1 (rs 1183423000, presence/absence), GSTT1 (rs1601993659, GSTP1 (rs1695, XRCC1 (rs1799782, C>T), (rs25489, A>G) XPC (rs2228001, A>C) polymorphisms. The between studied dividing into three age groups: 18-50, 51-85,...
Bisphenol A (BPA) is one of the most used additives in production many plastic products and may be released into environment by commonly products, such as food containers polycarbonate bottles. BPA recognized an endocrine disruptor able to produce adverse effects on reproduction system benthonic pelagic species. Polychaetes genus Ophryotrocha are small worms living amongst interstitial fauna nutrient-rich polluted habitats. Owing easy rearing laboratory short generation times, this species a...
Previous studies have highlighted the potential role of Mycobacterium avium subspecies paratuberculosis (MAP) and human endogenous retrovirus W (HERV-W) in pathogenesis type 1 diabetes (T1DM) among Sardinian subjects. To better understand how antibody responses evolve during disease progression, a serological evaluation IgG antibodies was performed children with T1DM collected at different time-points following onset disease. It is known that anti-PI anti-insulin (IAA) autoantibodies are...
ABSTRACT Background longevity is considered the result of interactions between environmental and genetic factors. Aim we investigated possible association body mass index frequencies APOE, ACE, eNOS , FTO gene polymorphisms with longevity. Subjects Method 1,100 healthy volunteers aged 10-100 were recruited. We genotyped subjects for polymorphisms. Data about height weight also collected. The sample was split in four age groups: 1-24, 25-49, 50-85 86-100. Results significant differences found...