A5068740924- Monoclonal and Polyclonal Antibodies Research
- Liver Disease Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Birth, Development, and Health
- RNA and protein synthesis mechanisms
- Glycosylation and Glycoproteins Research
- RNA Research and Splicing
- RNA modifications and cancer
- Insect and Arachnid Ecology and Behavior
- Marine Sponges and Natural Products
- Carcinogens and Genotoxicity Assessment
- DNA and Nucleic Acid Chemistry
- Lipid Membrane Structure and Behavior
- Viral Infectious Diseases and Gene Expression in Insects
- Olfactory and Sensory Function Studies
- Receptor Mechanisms and Signaling
- CAR-T cell therapy research
- Chemical Synthesis and Analysis
- Steroid Chemistry and Biochemistry
- Effects and risks of endocrine disrupting chemicals
- Neuroendocrine regulation and behavior
- Skin Protection and Aging
- Cell Adhesion Molecules Research
- Neurobiology and Insect Physiology Research
- Marine and coastal plant biology
University of Padua
2020
University of Turin
2018-2019
Istituto di Metodologie Chimiche
1990
Duke University Hospital
1989
Duke Medical Center
1989
Howard Hughes Medical Institute
1987-1989
Rockefeller University
1987-1988
University of Zurich
1981-1983
During B-cell differentiation, there is a dramatic switch in the RNA products of immunoglobulin mu heavy chain transcription unit. In mature B cell roughly equal production microseconds and micron RNA, whereas antibody-secreting plasma nearly exclusive RNA. A plasmid containing entire unit was properly regulated when assayed by transient transfection lymphoma plasmacytoma. contrast, no such regulation observed with separate plasmids that could produce only one or other Instead, poly(A) site...
Alternative processing of the immunoglobulin mu primary transcript results in regulated production mRNAs encoding secreted (microseconds) and membrane-bound (micro m) form IgM heavy chain during B-cell development. To elucidate basis for this control, we analyzed expression altered forms transcription unit. Deletion intron sequence between microseconds micro m exons, which reduces distance two poly(A) sites as well splice sites, enhances RNA. Correct is restored by insertion heterologous...
Oxybenzone or benzophenone-3 (2-hydroxy-4-methoxybenzophenone; BP-3) is a filter used in variety of personal care products for protection human skin and hair from damage by ultraviolet radiation. BP-3 suspected to exhibit endocrine disruptive properties. Indeed, it was found be able interact with the system causing alteration its homeostasis, consequent adverse health effects. Moreover, ubiquitously present environment, mostly aquatic ecosystems, risks organisms humans. In study, we analyzed...
Background: Longevity is considered the result of interactions between environmental and genetic factors.Aim: To investigate possible association body mass index frequencies APOE, ACE, eNOS FTO gene polymorphisms with longevity.Subjects methods: In total, 1100 healthy volunteers aged 10-100 were recruited. Subjects genotyped for polymorphisms. Data about height weight also collected. The sample was split into four age groups: 1-24, 25-49, 50-85 86-100 years.Results: Significant differences...
ABSTRACT Background longevity is considered the result of interactions between environmental and genetic factors. Aim we investigated possible association body mass index frequencies APOE, ACE, eNOS , FTO gene polymorphisms with longevity. Subjects Method 1,100 healthy volunteers aged 10-100 were recruited. We genotyped subjects for polymorphisms. Data about height weight also collected. The sample was split in four age groups: 1-24, 25-49, 50-85 86-100. Results significant differences found...