A5015916569- Peripheral Neuropathies and Disorders
- Hereditary Neurological Disorders
- Nerve injury and regeneration
- Myasthenia Gravis and Thymoma
- Neurological disorders and treatments
- Peripheral Nerve Disorders
- Transcranial Magnetic Stimulation Studies
- Botulinum Toxin and Related Neurological Disorders
- Monoclonal and Polyclonal Antibodies Research
- Vestibular and auditory disorders
- EEG and Brain-Computer Interfaces
- Neurological and metabolic disorders
- Glycogen Storage Diseases and Myoclonus
- Fetal and Pediatric Neurological Disorders
- Amyotrophic Lateral Sclerosis Research
- Autoimmune Neurological Disorders and Treatments
- RNA regulation and disease
- Endoplasmic Reticulum Stress and Disease
- Genetic Neurodegenerative Diseases
- Intracranial Aneurysms: Treatment and Complications
- Vasculitis and related conditions
- Immune Cell Function and Interaction
- Vascular Malformations Diagnosis and Treatment
- Ophthalmology and Eye Disorders
- Spatial Neglect and Hemispheric Dysfunction
Ospedale San Filippo Neri
2024
Ospedale "Floraspe Renzetti"
2022-2023
American Headache Society
2020
University of L'Aquila
2020
New York Proton Center
2020
University of Chieti-Pescara
2006-2016
Laboratory for Biomedical Neurosciences
2010-2014
Ospedale regionale di Lugano
2011
Ospedale SS. Annunziata
2007-2010
Institute of Aging
2009
<h3>Objective</h3> To electrophysiologically classify an Italian Guillain–Barré syndrome (GBS) population into demyelinating and axonal subtypes, to investigate how serial recordings changed the classification underline pitfalls in electrodiagnosis of GBS subtypes. <h3>Methods</h3> The authors applied two current electrodiagnostic criteria sets for subtypes 55 patients who had at least three motor sensory nerves. <h3>Results</h3> At first test, was almost identical with both criteria: 65–67%...
Whether or not antiganglioside antibodies are related to axonal demyelinating Guillain-Barré syndrome (GBS) is still a matter of controversy, as detailed in previous studies conducted Western and Asian countries.To clarify whether associated with dysfunction Japanese Italian GBS patient cohorts.Clinical electrophysiological profiles were reviewed for 156 patients collected from Japan (n=103) Italy (n=53). Serum IgG against GM1, GM1b, GD1a GalNAc-GD1a measured by ELISA the same laboratory....
Abstract We systematically investigated the effects of cathodal and anodal Transcranial Direct Current Stimulation (CtDCS, AtDCS) on electric activity primary motor cortex during a task. High‐density electroencephalography was used to define spatial diffusion tDCS after effects. Ten healthy subjects performed finger tapping task with right hand before three separate sessions 20 minutes Sham, AtDCS or CtDCS over left (M1). During movement, we found an increment low alpha band Event‐Related...
<h3>Background</h3> Acute motor axonal neuropathy (AMAN) and acute sensory (AMSAN) are due to an antiganglioside antibody mediated attack, thought be restricted fibres in AMAN. Sensory symptoms minor conduction abnormalities, however, have been reported some AMAN patients. <h3>Objective</h3> To verify whether truly spared AMSAN represent a continuum. <h3>Methods</h3> Serial studies 13 three patients were reviewed. evaluate the variation nerve action potential (SNAP) amplitude serial...
Cerebral cavernous malformations (CCMs) are vascular abnormalities that may cause seizures, intracerebral haemorrhages, and focal neurological deficits. Familial form shows an autosomal dominant pattern of inheritance with incomplete penetrance variable clinical expression. Three genes have been identified causing familial CCM: KRIT1/CCM1, MGC4607/CCM2, PDCD10/CCM3. Aim this study is to report additional PDCD10/CCM3 families poorly described so far which account for 10-15% hereditary...
Abstract Three patients developed acute pure sensory ataxic neuropathy. Two of the three had a recent Campylobacter jejuni infection. Patient 1 monospecific IgG anti‐GD1b. Patients 2 and 3 cross‐reactive anti‐GQ1b anti‐GD1b patient also anti‐GT1a. Motor nerve conduction studies were completely normal. Sensory conductions showed reduced amplitude or absent action potentials with normal slightly slowed velocities. In 2, serial electrophysiological reappearance improvement potential amplitudes...
Abstract In two patients with the pharyngeal–cervical–brachial variant (PCB) of Guillain–Barré syndrome (GBS), low amplitude distal compound muscle action potentials and partial motor conduction blocks normalized without development excessive temporal dispersion within 4 weeks. Sensory nerve significantly improved in or, when absent, rapidly became recordable at follow‐up. Besides axonal degeneration, PCB is characterized by reversible failure both sensory fibers continuous spectrum GBS...
Abstract We evaluated serum glial fibrillary acidic protein (GFAP) levels by enzyme‐linked immunosorbent assay (ELISA) in controls ( n = 30) and patients with chronic sensory‐motor axonal neuropathy (CSMAN) 30), inflammatory demyelinating polyneuropathy (CIDP) multifocal motor (MMN) primary muscular spinal atrophy (PMSA) 15). GFAP levels, expressed as optical density, were increased CSMAN (median 1.05) compared to 0.41; P < 0.05) CIDP 0.53, 0.05). They also PMSA 0.99) MMN 0.66; To...
Abstract Background and purpose There are different criteria for the diagnosis of variants chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). The 2021 European Academy Neurology/Peripheral Nerve Society (EAN/PNS) guidelines provide specific clinical each CIDP variant even if their therapeutical impact has not been investigated. Methods We applied EAN/PNS to 369 patients included in Italian database who fulfilled electrodiagnostic CIDP. Results According criteria, 245 achieved...
In the quest for susceptibility factors of inflammatory neuropathies, many genes implicated in pathogenesis autoimmune diseases have been investigated with negative or conflicting results. We studied, a gene candidate approach, CD1 system specialized capturing and presenting glycolipids to antigen‐specific T cells, SH2D2A encoding T‐cell‐specific adapter protein control early T‐cell activation. Guillain–Barré syndrome, an initially positive association study polymorphism CD1A CD1E was not...
To clarify the role of electroencephalography (EEG) as a promising marker severity in amyotrophic lateral sclerosis (ALS). We characterized brain spatio-temporal patterns activity at rest by means both spectral band powers and EEG microstates correlated these features with clinical scores.Eyes closed was acquired 15 patients ALS power calculated frequency bands, defined on basis individual alpha (IAF): delta-theta (1-7 Hz); low (IAF - 2 Hz IAF); high IAF + beta (13 25 Hz). microstate metrics...
Abstract Glial fibrillary acid protein (GFAP) is increased in serum and cerebrospinal fluid of patients with dementia, traumatic brain injury, stroke, multiple sclerosis. To determine whether GFAP Guillain–Barré syndrome (GBS) we evaluated 30 controls, 20 acute inflammatory demyelinating neuropathy (AIDP), 17 primary axonal GBS. Serum levels were GBS (median, 0.74) compared controls 0.41; P < 0.0001) AIDP 0.58; = 0.0015). correlated Hughes grades (serum r 0.74; 6 months after onset....
In the Schwann cells and neuronal plasma membranes gangliosides are organized in clusters forming complexes of microdomains termed lipid rafts. We investigated frequency, clinical correlates, fine specificity pro-inflammatory properties antibodies to ganglioside (GSCs) a Guillain Barré syndrome (GBS) population. 63 patients with different GBS variants we performed an ELISA for Campylobacter Jejuni ( C. jejuni), GSCs. studied GSCs by immunoabsorption study complement activation assay....