A5037616661- Amyotrophic Lateral Sclerosis Research
- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Botanical Research and Chemistry
- Trace Elements in Health
- Agricultural pest management studies
- Lipid metabolism and biosynthesis
- Alzheimer's disease research and treatments
- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Chromium effects and bioremediation
- Neurological diseases and metabolism
- Prion Diseases and Protein Misfolding
- Protein Hydrolysis and Bioactive Peptides
- Biochemical and Structural Characterization
- Probiotics and Fermented Foods
- Particle accelerators and beam dynamics
- Toxin Mechanisms and Immunotoxins
- Retinal and Macular Surgery
- Plant and fungal interactions
- Nitrogen and Sulfur Effects on Brassica
- Legume Nitrogen Fixing Symbiosis
- Ocular Surface and Contact Lens
- Vascular Malformations Diagnosis and Treatment
- Ocular Oncology and Treatments
University of Milan
2016-2024
University of Chieti-Pescara
2024
Thieme Medical Publishers (Germany)
2023
Emirates Foundation
2021
Shaikh Khalifa Medical City
2021
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
2014-2016
Interventi Geo Ambientali (Italy)
2014
Ospedale Maggiore
2013
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2013
University of Rome Tor Vergata
2009
To determine the feasibility of using posterior chamber intraocular contact lenses to treat myopia.Ambulatory surgery centers in Torino, Ancona, and Ivrea, Italy.The phakic lens is made a collagen copolymer. We implanted 15 these 14 patients with preoperative spherical equivalents ranging from -10.8 -24.0 diopters (D); average myopia was -15.3 D +/- 3.1 (SD). Average follow-up 7.0 1.95 months.Mean postoperative equivalent -2.0 1.6 D. Uncorrected visual acuity improved eyes. Best...
To evaluate long-term endothelial cell changes in eyes that had implantation of an iris-fixated phakic Artisan intraocular lens (IOL) for moderate to high myopia.Casa di Cura Villa Igea, Ancona, Italy.Forty-nine 30 patients having IOL myopia were prospectively examined. Preoperative specular microscopy and serial postoperative (Noncon Robo SP 8000, Konan Medical) performed over 5 years. Endothelial images collected the central region cornea before surgery 4, 12, 24, 36, 48, 60 months after...
Cerebral cavernous malformations (CCMs) are vascular abnormalities that may cause seizures, intracerebral haemorrhages, and focal neurological deficits. Familial form shows an autosomal dominant pattern of inheritance with incomplete penetrance variable clinical expression. Three genes have been identified causing familial CCM: KRIT1/CCM1, MGC4607/CCM2, PDCD10/CCM3. Aim this study is to report additional PDCD10/CCM3 families poorly described so far which account for 10-15% hereditary...
Abstract Applying a circular economy approach, this research explores the use of cheese whey permeate (CWP), by-product ultrafiltration, as cheap substrate for production bacterial cellulose (BC) and Sakacin-A, to be used in an antimicrobial packaging material. BC from acetic acid bacterium Komagataeibacter xylinus was boosted up 6.77 g/L by supplementing CWP with β-galactosidase. then reduced nanocrystals (BCNCs, 70% conversion yield), which were conjugated anti- Listeria bacteriocin...
ABSTRACT PURPOSE: To evaluate the safety and efficacy of iris claw phakic intraocular lens (Artisan; Ophtec BV, Groningen, The Netherlands) in patients with high myopia. METHODS: Between May 1999 July 2001, 93 Artisan lenses (IOLs) were implanted 60 affected by All underwent 24-month follow-up. power ranged from -7.5 to -22.0 diopters (D). Patients divided into two groups: group 1 (68 eyes), myopia -6.75 -15.50 D (SE), 2 (25 -16.0 -23.0 (SE). Pre- postoperative patient evaluation included...
Several food-derived molecules, including proteins and peptides, can show bioactivities toward the promotion of well-being disease prevention in humans. There is still a lack information about potential effects on immune inflammatory responses mammalian cells following ingestion seed storage proteins. This study, for first time, describes immunomodulation capacity chenopodin, major protein component quinoa seeds. After characterizing molecular features purified protein, we were able to...
recently much studies evidenced the potential role of photo-biomodulation (PBM) in patients affected by Age-related Macular Degeneration (AMD). We designed a new wearable device for self-medication that employs same broadband red light described literature, but with extremely low irradiance.
Inflammation plays a key role in various diseases such as pancreatitis, cancer, and rheumatoid arthritis. Acute inflammation involves processes like vasodilation, increased vascular permeability, leukocyte accumulation, which lead to cellular damage due reactive oxygen species (ROS). Low-frequency electromagnetic fields (ELF-EMFs) have shown potential reducing oxidative stress inflammation. This study assesses the effectiveness of new wearable device containing graphene quantum dots Jurkat T...
Food proteins and peptides are able to exert a variety of well-known bioactivities, some which related well-being disease prevention in humans animals. Currently, an active trend research focuses on chronic inflammation oxidative stress, delineating their major pathogenetic role age-related diseases forms cancer. The present study aims investigate the potential effects pseudocereal derived stress. After purification attribution protein classes according classic Osborne's classification,...
We describe a 5.3-year-old girl with autism, mental retardation, hypotonia, marked speech delay, and mild dysmorphic features 22q11.2 duplication. Her mother carries the same duplication presents cleft palate, normal intelligence. The clinical behavioural phenotype of this relatively new syndrome is very heterogeneous, high variability also in familiar cases. Up till now, about 50 cases have been reported, but only three them are associated autistic disorders. propose that addition to...
To present the mid-term results of a prospective multicenter study on canaloplasty surgery in chronic open-angle glaucoma.A total 218 eyes from 197 patients with glaucoma under maximum tolerated medical therapy underwent within time period 42 months 3 different Italian eye centers. All complete ophthalmic examination every 6 months. The follow-up ranged to months.The entire procedure according standard protocol could not be performed 20 (9.2%). A 198 178 mean 23.1±10.6 were taken into...
In recent years, the interest in increasingly sustainable agriculture has also turned attention towards new cover crops suitable for use marginal areas that could enter food chain as protein and oil sources or biodiesel production. this scenario, Camelina sativa is a perfect crop to study. an annual herbaceous plant belonging Brassicaceae which interesting terms of its content, since seeds contain about 40% oils, with high level polyunsaturated fatty acids (30–40% alpha linolenic acid,...
Camelina sativa , commonly referred to as camelina or false flax, has emerged a promising cover crop with the potential mitigate climate change—a pressing global challenge that demands urgent and sustainable solutions. Belonging Brassicaceae family native Europe Central Asia, is an oilseed known for its resilience in diverse climates, including arid semi-arid regions, making it adaptable various environments. A breeding program started from study of six winter varieties five spring...
Many recent studies have explored the healing properties of extremely low-frequency electromagnetic field (ELF-EMF) to utilize electromagnetism for medical purposes. The non-invasiveness induction makes it valuable supportive therapy in various degenerative pathologies with increased oxidative stress. To date, no harmful effects been reported or documented. We designed a small, wearable device which does not require power source. consists substrate made polyethylene terephthalate and an...
Current methods for the production of natural vanilla extract are long and tedious, efficiency vanillin extraction is usually conditioned by different factors during traditional curing process (temperatures weather conditions). As an important fraction present in form glucovanillin green beans, endogenous β-glucosidases contribute to its hydrolysis; however, these enzymes lose process. The use extremophilic organisms as a source appropriate exogenous enzyme can offer valid alternative when...
Lupin species provide essential nutrients and bioactive compounds. Within pulses, they have one of the highest contents proteins fibers are among poorest in carbohydrates. The Mediterranean region is an important cradle area origin domestication cultivated white lupin (Lupinus albus L.). In this work, we present characterization 19 landraces collected from several sites southern Italy, characterized by different pedoclimatic conditions. protein electrophoretic patterns, total polyphenols,...
The Linac for Image Guided Hadron Therapy (LIGHT) system has been developed as the first commercial high-frequency linac-based proton therapy accelerator system. As part of development process and technical validation concept, a reduced energy prototype linac (including all key functional aspects full accelerator) designed tested in parallel with preparation work full-scale LIGHT construction, installation, commissioning beam allowed identification gaps design improvements before transfer to...
γ-conglutin (γC) is a major protein of Lupinus albus seeds, but its function still unknown. It shares high structural similarity with xyloglucan-specific endo-glucanase inhibitor proteins (XEGIPs) and, to lesser extent, Triticum aestivum endoxylanase inhibitors (TAXI-I), active against fungal glycoside hydrolases GH12 and GH11, respectively. However, γC lacks both these inhibitory activities. Since β-galactomannans are components the cell walls endosperm in several legume plants, we tested...
γ-Conglutin (γ-C) is the glycoprotein from edible seed L. albus, studied for long time its postprandial glycaemic regulating action. It still lacks clear information on what could happen at meeting point between protein and organism: intestinal barrier. We compared an in vitro system involving Caco-2 IPEC-J2 cells with ex vivo using pig ileum jejunum segments to study γ-C transport apical basolateral compartment, effects D-glucose uptake glucose transporters expression. Finally, we potential...
The human parasitic disease Schistosomiasis is caused by the Schistosoma trematode flatworm that infects freshwaters in tropical regions of world, particularly Sub-Saharan Africa, South America, and Far-East. It has also been observed as an emerging Europe, due to increased immigration. In addition improved therapeutic strategies, it imperative develop novel, rapid, sensitive diagnostic tests can detect parasite, allowing timely treatment. Present diagnosis difficult involves...
Okara is a soybean transformation agri-food by-product, the massive production of which currently poses severe disposal issues. However, its composition rich in seed storage proteins, which, once extracted, can represent an interesting source bioactive peptides. Antimicrobial and antifungal proteins peptides have been described plant seeds; thus, okara valuable compounds, exploitable for integrated pest management. The aim this work to describe rapid economic procedure isolate from okara,...
This study is meant to characterize the serum proteome in a small geographical cluster of sporadic ALS subjects originating from restricted area and sharing same environmental exposure, broader context evaluating relevance factors disease onset, status, progression. An Artificial Neural Network based software used compare relative abundance proteins identified as different (by means bi-dimensional electrophoresis mass spectrometry) patients age-matched healthy controls. The patient's group...