A5074062388- Reading and Literacy Development
- Genetics and Neurodevelopmental Disorders
- Cognitive and developmental aspects of mathematical skills
- Language Development and Disorders
- Child Development and Digital Technology
- Autism Spectrum Disorder Research
- Child and Adolescent Psychosocial and Emotional Development
- Children's Physical and Motor Development
- Cognitive Abilities and Testing
- Attention Deficit Hyperactivity Disorder
- Child and Animal Learning Development
- Infant Development and Preterm Care
- Neonatal and fetal brain pathology
- Tactile and Sensory Interactions
- EEG and Brain-Computer Interfaces
- Congenital heart defects research
- Early Childhood Education and Development
- Assistive Technology in Communication and Mobility
- Advanced Neuroimaging Techniques and Applications
- Neuroscience, Education and Cognitive Function
- Muscle Physiology and Disorders
- Educational and Psychological Assessments
- Analog and Mixed-Signal Circuit Design
- Digital Mental Health Interventions
- Health, Environment, Cognitive Aging
IRCCS Eugenio Medea
2015-2025
University of Pavia
2023-2025
Vita-Salute San Raffaele University
2010-2013
Abstract Action video-games (AVGs) could improve reading efficiency, enhancing not only visual attention but also phonological processing. Here we tested the AVG effects upon three consolidated language-based predictors of development in a sample 79 pre-readers at-risk and 41 non-at-risk for developmental dyslexia. At-risk children were impaired either phonemic awareness (i.e., phoneme discrimination task), working memory pseudoword repetition task) or rapid automatized naming RAN colours...
Objective(s) Developmental dyslexia is a heritable condition, with genetic factors accounting for 44–75% of the variance in performance tests reading component subphenotypes. Compelling linkage and association evidence supports quantitative trait locus 6p21.3 region that encodes gene called DCDC2. In this study, we explored contribution two DCDC2 markers to dyslexia, related memory phenotypes nuclear families Italian origin. Methods The 303 recruited on basis having proband developmental...
Developmental dyslexia (DD) is a heritable neurodevelopmental reading disorder that could arise from auditory, visual, and cross-modal integration deficits. A deletion in intron 2 of the DCDC2 gene (hereafter DCDC2d) increases risk for DD related phenotypes. In this study, first we report illusory visual motion perception-specifically processed by magnocellular-dorsal (M-D) stream-is impaired children with compared age-matched reading-level controls. Second, test specificity DCDC2d effects...
Humans possess a communication system based on spoken and written language. Other animals can learn vocalization by imitation, but this is not equivalent to human Many genes were described be implicated in language impairment (LI) developmental dyslexia (DD), their evolutionary history has been thoroughly analyzed. Herein we analyzed the evolution of ten involved DD LI. Results show that LI for mammals aves was comparable vocal-learner species non-learners. For lineage, several sites showing...
While the genetic and environmental contributions to developmental dyslexia ( DD ) have been studied extensively, effects of identified risk susceptibility specified hazardous factors usually investigated separately. We assessed potential gene‐by‐environment GxE interactions on ‐related reading, spelling memory phenotypes. The presence were for DYX1C1 , DCDC2 KIAA0319 ROBO1 genes, seven moderators in 165 nuclear families which at least one member had by implementing a general test...
Although individual differences in reading-related skills are largely influenced by genetic variation, the molecular basis of heritability this phenotype is far from understood. Functional single-nucleotide polymorphisms spanning reading-candidate genes and genome-wide significant top hits were identified. By using a multiple-predictor/multiple-mediator framework, we investigated whether relationships between functional variants (DYX1C1-rs3743205, DYX1C1-rs57809907, KIAA0319-rs9461045,...
Dyslexia is a specific impairment in reading that affects 1 10 people. Previous studies have failed to isolate single cause of the disorder, but several candidate genes been reported. We measured motion perception two groups dyslexics, with and without deletion within DCDC2 gene, risk gene for dyslexia. found particularly strong at high spatial frequencies population carrying deletion. The data suggest deficits processing occur genotype, rather than entire dyslexia population, contributing...
Reading disability (RD) and language impairment (LI) are common neurodevelopmental disorders with moderately strong genetic components lifelong implications. RD LI marked by unexpected difficulty acquiring processing written verbal language, respectively, despite adequate opportunity instruction. LI-and their associated deficits-are complex, multifactorial, often comorbid. Genetic studies have repeatedly implicated the DYX2 locus, specifically genes DCDC2 KIAA0319, in RD, recent suggesting...
Developmental dyslexia (DD) and attention deficit/hyperactivity disorder (ADHD) are among the most common neurodevelopmental disorders, whose etiology involves multiple risk factors. DD ADHD co-occur in same individuals much more often than would be expected by chance. Several studies have found significant bivariate heritability, specific genes associated with either or been investigated for association other disorder. Moreover, there likely to gene-by-gene gene-by-environment interaction...
Developmental dyslexia (DD) is a complex heritable condition associated with impairments in multiple neurocognitive domains. Substantial heritability has been reported for DD and related phenotypes, candidate genes have identified. Recently, gene human cognitive processes, that is, GRIN2B, found to be significantly working memory German sample. In this study, we explored the contribution of six GRIN2B markers key DD-related phenotypes by association analyses sample Italian nuclear families....
Although a genetic component is known to have an important role in the etiology of developmental dyslexia (DD), we are far from understanding molecular etiopathogenetic pathways. Reduced measures neurobiological functioning related reading (dis)ability, i.e. endophenotypes (EPs), promising targets for gene finding and elucidation underlying mechanisms. In sample 100 nuclear families with DD (229 offspring) 83 unrelated typical readers, tested whether set well-established, cognitive...
Language‐based Learning Disabilities (LLDs) encompass a group of complex, comorbid, and developmentally associated deficits in communication. Language impairment developmental dyslexia (DD) represent the most recognized forms LLDs. Substantial genetic correlations exist between language reading (dis)abilities. Common variants FOXP2 gene were consistently with language‐ reading‐related neuropsychological neuroanatomical phenotypes. We tested effect common variant, that is, rs6980093 (A/G), on...
The quantity and quality of environmental stimuli contexts are crucial for children’s development. Following the outbreak SARS-CoV-2 (COVID-19), restrictive measures have been implemented, constraining social lives changing their daily routines. To date, there is a lack research assessing long-lasting impacts that these changes had on language emotional–behavioral In large sample preschoolers (N = 677), we investigated (a) effects in family life activities over first Italian nationwide...
Although dyslexia runs in families, several putative risk factors that cannot be immediately identified as genetic predict reading disability. Published studies analyzed one or a few at time, with relatively inconsistent results. To assess the contribution of to development dyslexia, we conducted case-control study 403 Italian children, 155 by implementing stepwise logistic regression applied entire sample, and then boys girls separately. Younger parental age child's birth, lower education,...
This study tested the role of temporary memory, measured by phonological short-term memory (pSTM) and verbal working (vWM), as a mediator effect 3 putative risk factors (i.e., socioeconomic status, home literacy environment, birth gestational age) upon expressive receptive language.A community-based sample 646 Italian children aged 6-11 years was assessed with comprehensive battery language cognitive tests. A mediation analysis used to examine whether mediates environmental/biological...