A5088679411- Alzheimer's disease research and treatments
- Nutrition and Health in Aging
- Genetics, Aging, and Longevity in Model Organisms
- Frailty in Older Adults
- Neuroinflammation and Neurodegeneration Mechanisms
- Telomeres, Telomerase, and Senescence
- Tryptophan and brain disorders
- Muscle Physiology and Disorders
- Mitochondrial Function and Pathology
- Vitamin D Research Studies
- Birth, Development, and Health
- Inflammation biomarkers and pathways
- Genomics and Rare Diseases
- Bioinformatics and Genomic Networks
- Health, Environment, Cognitive Aging
- Genetic Associations and Epidemiology
- Dementia and Cognitive Impairment Research
- Neurological Disease Mechanisms and Treatments
- Nuclear Receptors and Signaling
- Vagus Nerve Stimulation Research
- Adipose Tissue and Metabolism
- Intensive Care Unit Cognitive Disorders
- Nutrition, Genetics, and Disease
- Stress Responses and Cortisol
- Adenosine and Purinergic Signaling
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2013-2025
Ospedale Maggiore
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2024
University of Milan
2013-2020
Moriggia Pelascini Hospital
2013
Institute of Biomedical Technologies
2013
Institute of Molecular Bioimaging and Physiology
2013
Universidade Federal de Uberlândia
2006
Extreme longevity is the paradigm of healthy aging as individuals who reached extreme decades human life avoided or largely postponed all major age-related diseases. In this study, we sequenced at high coverage (90X) whole genome 81 semi-supercentenarians and supercentenarians [105+/110+] (mean age: 106.6 ± 1.6) 36 unrelated geographically matched controls age 68.0 5.9) recruited in Italy. The results showed that 105+/110+ are characterized by a peculiar genetic background associated with...
Extracellular vesicles (EVs) are nanosized released by almost all body tissues, representing important mediators of cellular communication, and thus promising candidate biomarkers for neurodegenerative diseases like Alzheimer’s disease (AD). The aim the present study was to isolate total EVs from plasma characterize their microRNA (miRNA) contents in AD patients. We isolated recruited subjects using ExoQuickULTRA exosome precipitation solution (SBI). Subsequently, circulating were...
Neuroinflammation plays a role in the aetiopathogenesis of Alzheimer's disease (AD). Triggering receptor expressed on myeloid cells 2 (TREM2), cell surface immunoglobulin superfamily, seems to have protective anti-inflammatory activity AD.Triggering expression was analysed peripheral blood mononuclear from healthy subjects (CT) and patients with either AD or mild cognitive impairment (MCI). MCI were re-evaluated at 2-year follow-up investigate their progression (MCI-AD) lack thereof...
ABSTRACT Physical exercise has been associated with healthier aging trajectories, potentially preventing or mitigating age‐related declines. This occurs through a complex, yet poorly characterized network of multi‐organ interactions involving mitochondrial, inflammatory, and cell death/survival pathways. Here, we comprehensively evaluated the 12‐week VIVIFRAIL multicomponent protocol in physically frail ( n = 16, mean age 81.4 ± 5.6) robust 50, mean‐age 73.6 4.7) old individuals. Before (T0)...
Age and short leukocyte telomeres have been associated with a higher risk of Alzheimer's disease (AD). Inflammation is involved in AD it suggested that anti-inflammatory interleukin-10 (IL-10) may partly antagonize these processes.The aim to correlate telomere length (TL) peripheral blood mononuclear cells (PBMC) from patients progression rate. Moreover, we evaluated whether TL was IL-10 production by unstimulated or amyloid-β (Aβ)-stimulated PBMC.We enrolled 31 late-onset 20 age-matched...
Thyroid hormones (FT3, FT4) and thyroid-stimulating hormone (TSH) were evaluated in a population of 672 well-characterized Italian subjects (age range: 52-113 years), including an unprecedented number centenarians, semi-supercentenarians, as well centenarian's offspring age-matched elderly (CENT, 105+, CENTOFF, CTRL, respectively). The results show that FT3 level FT3/FT4 ratio decrease while FT4 TSH increase age-dependent manner. In CENT/105+, higher level, lower are associated with impaired...
Microglia performs a variety of functions during brain development designed to maintain homeostasis. Triggering receptor expressed on myeloid cells 2 (TREM2) is in microglial modulating phagocytosis, cytokine production, cell proliferation, and survival. Interestingly, the levels soluble TREM2 (the secreted ectodomain TREM2, sTREM2) were higher cerebrospinal fluid (CSF) from Alzheimer's disease (AD) patients than subjects without cognitive decline. It noteworthy that, while CSF sTREM2 have...
Inflammaging is a low-grade inflammatory state that can be considered an adaptive process aimed at stimulating appropriate anti-inflammatory response. Frailty determined by the accumulation of molecular and cellular defects accumulated throughout life; therefore, frailty computation could valuable tool for measuring biological age. This study aims to analyse association between markers both chronological age "per se" frailty. We studied 452 persons aged 43-114 years. A Index (FI) was...
In the diagnosis of Alzheimer's disease (AD) total tau (T-tau), phosphorylated at threonine 181 (P-tau181), and 42 amino acid isoform alpha β-amyloid (Aβ) are well established surrogate CSF markers. However, there is a constant need for new diagnostic markers to identify very early stage. The identification molecules AD monitoring in hampered by several "confounding" factors including intra- inter-individual, pre-analytical analytical variabilities. an attempt partially overcome patient's...
We investigated IL-10 and IL-6 production in amyloid-β (Aβ) stimulated peripheral blood mononuclear cells (PBMCs) twenty Alzheimer's disease (AD) patients with slow progression, eleven fast age-matched controls. Promoter polymorphisms (position -592, -819, -1082), (-174), transforming growth factor-β1 (TGF-β1) (-10, -25), interferon-γ (IFN-γ) (-874), tumor necrosis factor-α (TNF-α) (-308) genes were analyzed. after Aβ stimulation was high PBMCs from decliners almost completely abrogated...
Dysfunctions in liver metabolic activities may increase the risk of cognitive impairment and dementia. In a cohort community-dwelling older persons investigated for suspected decline, we studied association between status dementia, considering sex frailty contribution. Serum alanine aminotransferase (ALT) aspartate (AST) concentrations, AST/ALT ratio were used to assess function 419 adults (248 with dementia 171 age- sex-matched subjects without decline). Although serum concentrations...