A5068738903- Genetics, Aging, and Longevity in Model Organisms
- Alzheimer's disease research and treatments
- Telomeres, Telomerase, and Senescence
- Genetic and phenotypic traits in livestock
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetic Mapping and Diversity in Plants and Animals
- Mitochondrial Function and Pathology
- Tryptophan and brain disorders
- Nutrition and Health in Aging
- Inflammation biomarkers and pathways
- Sphingolipid Metabolism and Signaling
- Epigenetics and DNA Methylation
- Cerebrospinal fluid and hydrocephalus
- Vitamin D Research Studies
- Antioxidant Activity and Oxidative Stress
- Nuclear Receptors and Signaling
- Adenosine and Purinergic Signaling
- Vagus Nerve Stimulation Research
- Genomics and Rare Diseases
- Frailty in Older Adults
- Adipose Tissue and Metabolism
- Microbial infections and disease research
- Neurological Disease Mechanisms and Treatments
- Stress Responses and Cortisol
- Dietary Effects on Health
University of Cagliari
2023
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2013-2021
University of Milan
1988-2021
Institute of Molecular Bioimaging and Physiology
2013
Moriggia Pelascini Hospital
2013
Institute of Biomedical Technologies
2013
Istituti di Ricovero e Cura a Carattere Scientifico
2013
Istituto Sperimentale per la Zootecnia
1995
Extreme longevity is the paradigm of healthy aging as individuals who reached extreme decades human life avoided or largely postponed all major age-related diseases. In this study, we sequenced at high coverage (90X) whole genome 81 semi-supercentenarians and supercentenarians [105+/110+] (mean age: 106.6 ± 1.6) 36 unrelated geographically matched controls age 68.0 5.9) recruited in Italy. The results showed that 105+/110+ are characterized by a peculiar genetic background associated with...
Neuroinflammation plays a role in the aetiopathogenesis of Alzheimer's disease (AD). Triggering receptor expressed on myeloid cells 2 (TREM2), cell surface immunoglobulin superfamily, seems to have protective anti-inflammatory activity AD.Triggering expression was analysed peripheral blood mononuclear from healthy subjects (CT) and patients with either AD or mild cognitive impairment (MCI). MCI were re-evaluated at 2-year follow-up investigate their progression (MCI-AD) lack thereof...
Blood samples were collected from more than 100 animals in each of 2 Spanish cattle breeds (Retinto and De Lidia), Portuguese (Alentejana Mertolenga), American Longhorn cattle. All for the 4 Iberian tested 20 polymorphic systems; 19 20. For breed an average inbreeding coefficient was estimated by a comparison observed expected heterozygosity at 7 or 8 codominant systems tested. had positive values but only 3 estimates that statistically significantly different 0: Lidia with f = 0.17, Retinto...
Age and short leukocyte telomeres have been associated with a higher risk of Alzheimer's disease (AD). Inflammation is involved in AD it suggested that anti-inflammatory interleukin-10 (IL-10) may partly antagonize these processes.The aim to correlate telomere length (TL) peripheral blood mononuclear cells (PBMC) from patients progression rate. Moreover, we evaluated whether TL was IL-10 production by unstimulated or amyloid-β (Aβ)-stimulated PBMC.We enrolled 31 late-onset 20 age-matched...
Idiopathic normal pressure hydrocephalus (iNPH) is characterized by reversible neurological symptoms due to an impairment in cerebrospinal fluid (CSF) clearance. In these patients, cognitive functions are severely impaired, with a scenario similar Alzheimer's disease (AD), making the differential diagnosis difficult and highlighting need of new markers. We analyzed composition sphingolipids (SLs) serum, combining single phase extraction high-performance thin-layer chromatography (HPTLC)...
We investigated IL-10 and IL-6 production in amyloid-β (Aβ) stimulated peripheral blood mononuclear cells (PBMCs) twenty Alzheimer's disease (AD) patients with slow progression, eleven fast age-matched controls. Promoter polymorphisms (position -592, -819, -1082), (-174), transforming growth factor-β1 (TGF-β1) (-10, -25), interferon-γ (IFN-γ) (-874), tumor necrosis factor-α (TNF-α) (-308) genes were analyzed. after Aβ stimulation was high PBMCs from decliners almost completely abrogated...
The line between vascular dementia (VaD) and Alzheimer's disease (AD) is often blurred. In this study we investigated whether adenosine A2A receptor (A2A R) expression can be used to differentiate VaD AD. We evaluated the of th
We describe a case of late onset frontotemporal dementia carrying the g.1977_1980 delCACT (Thr272fs) mutation in progranulin (GRN) gene, characterized by positive family history for and clinical phenotype resembling with Lewy bo
Summary Genetic distances among five of the most important Italian native sheep breeds were estimated by using gene frequencies four blood group and seven protein loci three different computing methods. The values distance matrices highly correlated. found within range reported in literature for local breeds. Shorter fitted historical evidence migrations.