A5084873108- MicroRNA in disease regulation
- Sex and Gender in Healthcare
- Melanoma and MAPK Pathways
- Brain Metastases and Treatment
- Epigenetics and DNA Methylation
- Nuclear Receptors and Signaling
- Bioinformatics and Genomic Networks
- Histone Deacetylase Inhibitors Research
- RNA Interference and Gene Delivery
- Computational Drug Discovery Methods
- RNA modifications and cancer
- Cancer-related gene regulation
- Alzheimer's disease research and treatments
- RNA Research and Splicing
- Genetics, Aging, and Longevity in Model Organisms
- Animal Disease Management and Epidemiology
- Molecular Biology Techniques and Applications
- Single-cell and spatial transcriptomics
- Circular RNAs in diseases
Centro de Investigacion Principe Felipe
2022-2024
Abstract Background The incidence of Alzheimer's disease (AD)—the most frequent cause dementia—is expected to increase as life expectancies rise across the globe. While sex-based differences in AD have previously been described, there remain uncertainties regarding any association between sex and disease-associated molecular mechanisms. Studying sex-specific expression profiles regulatory factors such microRNAs (miRNAs) could contribute more accurate diagnosis treatment. Methods A systematic...
ABSTRACT Melanoma, an aggressive form of skin cancer with a high mortality rate, has recently experienced increase in incidence. Consequently, the search for biomarkers, such as microRNAs (miRNAs), to facilitate early detection and management patients represents significant current concern. To identify these potential we developed novel integrative strategy. This involved conducting systematic review melanoma studies accordance PRISMA guidelines, followed by performance exploratory analysis...
Melanoma represents a critical clinical challenge due to its high incidence rates and unfavorable outcomes. This type of skin cancer presents unique adaptability the brain microenvironment, but underlying molecular mechanisms are poorly understood. To further characterize tumor neurobiology, we explore relation between transcriptional profiles melanoma metastasis (MBM) neurodegenerative diseases Alzheimer's disease, Parkinson's multiple sclerosis. Through an in silico approach, unveiled...
Abstract One of the major challenges in addressing multiple sclerosis is to understand progression trajectory patients. The pathological process evolves from acute phases predominantly driven by inflammation transitioning progressive profiles where neurodegeneration takes precedence. It remains unresolved why this course highly heterogeneous among Currently we know that sex variable plays a crucial role its understanding. Females are 2-3 times more likely suffer while males’ faster with...
Abundant evidence supports the significant impact of biological sex on various aspects Parkinson Disease (PD), including incidence, progression, symptoms or response to treatment. The incidence and prevalence disease is higher in males, while its age onset earlier than females. There are also differences symptomatology, both motor non-motor. In female PD, tremor, pain, depression dysphagia predominant, whereas male freezing gait, camptocormia, cognitive impairment urinary dysfunction more...
<title>Abstract</title> <bold>Background:</bold>The incidence of Alzheimer's disease (AD) - the most frequent cause dementia is expected to increase as life expectancies rise across globe. While sex-based differences in AD have previously been described, there remain uncertainties regarding any association between sex and disease-associated molecular mechanisms. Studying sex-specific expression profiles regulatory factors such microRNAs (miRNAs) could contribute more accurate diagnosis...
Abstract While sex-based differences in various health scenarios have been thoroughly acknowledged the literature, we lack a deep analysis of sex as variable this context. To fill knowledge gap, created MetaFun an easy-to-use web-based tool to meta-analyze multiple transcriptomic datasets with perspective gain major statistical power and biological soundness. Furthermore, can be used perform case-control meta-analyses, allowing researchers basic programming skills access methodology....
Abstract Background As the housekeeping genes (HKG) generally involved in maintaining essential cell functions are typically assumed to exhibit constant expression levels across types, they commonly employed as internal controls gene studies. Nevertheless, HKG may vary profile according different variables introducing systematic errors into experimental results. Sex bias can indeed affect display, however, up date, sex has not been considered a biological variable. Methods In this study, we...