A5013354252- Transplantation: Methods and Outcomes
- Multiple Sclerosis Research Studies
- Organ Transplantation Techniques and Outcomes
- Immunotherapy and Immune Responses
- Renal Transplantation Outcomes and Treatments
- T-cell and B-cell Immunology
- Neuroinflammation and Neurodegeneration Mechanisms
- Cytomegalovirus and herpesvirus research
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- RNA Research and Splicing
- Immune responses and vaccinations
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Toxoplasma gondii Research Studies
- Adenosine and Purinergic Signaling
- Immunodeficiency and Autoimmune Disorders
- Cellular Mechanics and Interactions
- Mechanical Circulatory Support Devices
- Craniofacial Disorders and Treatments
- Chemokine receptors and signaling
- Psoriasis: Treatment and Pathogenesis
- Nasal Surgery and Airway Studies
- Cardiac Valve Diseases and Treatments
- Pericarditis and Cardiac Tamponade
University of Toronto
1994-2025
University Health Network
2020-2024
Toronto General Hospital
2024
Hospital for Sick Children
1994-1997
SickKids Foundation
1994-1997
Anti-CD20 therapy to deplete B cells is highly efficacious in preventing new white matter lesions patients with relapsing-remitting multiple sclerosis (RRMS), but its protective capacity against gray injury and axonal damage unclear. In a passive experimental autoimmune encephalomyelitis (EAE) model whereby T H 17 promote brain leptomeningeal immune cell aggregates, we found that anti-CD20 treatment effectively spared myelin content prevented myeloid activation, oxidative damage,...
Background: Achieving symmetry in secondary cleft rhinoplasty is challenging even for the most skilled surgeon. The authors present their technique and outcomes of using a circumferential alar rim graft to relocate cleft-sided anterior ala superiorly anteriorly. graft, under tension, anchored septum at one end intermediate crus other, exerting an upward anteriorly projected force. Methods: Adult patients with unilateral lip palate who underwent between 2013 2022, (CARG) technique, were...
Subpial demyelination is a specific hallmark of multiple sclerosis and correlate disease progression. Although the mechanism(s) that mediate pathogenesis in subpial compartment remain unclear, it has been speculated inflammation overlying meninges may be associated with injury. Here we show adoptive transfer proteolipid protein-primed Th17 cells into SJL/J recipient mice induces microglial/macrophage activation, disruption glial limitans, evidence an oxidative stress response. This pathology...
Nuclear RNA splicing occurs in an RNA-protein complex, termed the spliceosome. U4/U6 snRNP is one of four essential small nuclear ribonucleoprotein (snRNP) particles (U1, U2, U5 and U4/U6) present contains two snRNAs (U4 U6) a number proteins. We report here identification characterization human genes encoding U4/U6-associated factors, Hprp3p Hprp4p, respectively. 77 kDa protein, which homologous to Saccharomyces cerevisiae factor Prp3p. Amino acid sequence analysis revealed putative...
The PRP4 protein of Saccharomyces cerevisiae is an essential part the U4/U6 snRNP, a component mRNA splicing apparatus. As approach to determination structure–function relationships in protein, we have isolated more than fifty new alleles gene through random and site-directed mutagenesis, analyzed phenotypes many them. Twelve fourteen single-point mutations that give rise temperature-sensitive (ts) or null are located portion corresponds β-transducin-like region protein; remaining two...
Abstract In multiple sclerosis (MS), the leptomeninges (LM) are populated with immune cell aggregates that correlate disease progression. The impact of LM inflammation on adjacent dura is largely unknown. Using a mouse model MS induces brain and age-dependent progression, we found encephalitogenic T cells B220 high B accumulate substantially in parenchyma both young aged mice, while remains relatively inert. We also observed population anti-CD20 resistant low bone marrow virtually disappear...
<title>Abstract</title> Type II conventional dendritic cells (cDC2) are functionally and phenotypically heterogenous. Previous work identified two major cDC2 subsets (cDC2A cDC2B); however, the underlying microenvironmental cues governing their distinct differentiation pathways remain unclear. Here we delineate sequential signals required for cDC2A specification maintenance. We show that T-bet+ cDC2A, arising from Clec9a+ DC progenitor, express retinol receptor RBPR2, require cell-intrinsic...