A5007636498- Multiple Sclerosis Research Studies
- Systemic Lupus Erythematosus Research
- Viral Infections and Immunology Research
- Virology and Viral Diseases
- T-cell and Retrovirus Studies
- Radioactivity and Radon Measurements
- Heavy Metal Exposure and Toxicity
- Psychology of Moral and Emotional Judgment
- Homelessness and Social Issues
- Long-Term Effects of COVID-19
- Urban, Neighborhood, and Segregation Studies
- Mosquito-borne diseases and control
- Disaster Response and Management
- Viral Infections and Vectors
- COVID-19 epidemiological studies
- Systemic Sclerosis and Related Diseases
- COVID-19 and healthcare impacts
- Misinformation and Its Impacts
- Food Security and Health in Diverse Populations
- Mercury impact and mitigation studies
- Vaccine Coverage and Hesitancy
- Emergency and Acute Care Studies
Dominican University of California
2020-2024
University of California System
2024
University of California, San Francisco
2008-2009
Multiple Sclerosis Foundation
2008
Multiple sclerosis (MS), a chronic disorder of the central nervous system and common cause neurological disability in young adults, is characterized by moderate but complex risk heritability. Here we report results genome-wide association study performed 1000 prospective case series well-characterized individuals with MS group-matched controls using Sentrix® HumanHap550 BeadChip platform from Illumina. After stringent quality control data filtering, compared allele frequencies for 551 642...
Genetic susceptibility to multiple sclerosis (MS) is associated with the human leukocyte antigen (HLA) DRB1*1501 allele. Here we show a clear association between carrier status and four domains of disease severity in an investigation genotype-phenotype associations 505 robust, clinically well characterized MS patients evaluated cross-sectionally: (i) reduction N-acetyl-aspartate (NAA) concentration within normal appearing white matter (NAWM) via (1)HMR spectroscopy (P = 0.025), (ii) increase...
We investigated the association between 52 risk variants identified through genome-wide studies and disease severity in multiple sclerosis (MS).Ten unique MS case data sets were analyzed. The Multiple Sclerosis Severity Score (MSSS) was calculated using Expanded Disability Status Scale at study entry duration. MSSS considered as a continuous variable 2 dichotomous variables (median extreme ends; of ≤5 vs >5 <2.5 ≥7.5, respectively). Single nucleotide polymorphisms (SNPs) examined...
Health-related quality of life (HRQOL) is reduced in multiple sclerosis (MS). It unclear whether HRQOL associated with white matter lesion burden or measures brain atrophy.A cross-sectional baseline analysis 507 patients MS a prospective cohort study at the University California, San Francisco was performed. Multivariate linear regression models were used to determine MRI Emotional Well-Being and Thinking/Fatigue subscale scores Functional Assessment Multiple Sclerosis, validated measure MS....
Abstract Background We aimed to determine if salivary cadmium (Cd) levels had any association with breast density, hoping establish a less invasive cost‐effective method of stratifying Cd burden as an environmental cancer risk factor. Methods Salivary were quantified from the Marin Women's Study, County, California population composite. Volumetric compositional density (BD sxa ) data measured by single x‐ray absorptiometry techniques. Digital screening mammography was performed San Francisco...
Abstract Vaccine hesitancy—the reluctance, delay, or refusal to vaccinate regardless of availability—is not a new concept in psychology, medicine, public health. However, given the emotions surrounding COVID‐19 vaccine, hesitancy has proven difficult overcome. To‐date, bulk available data on vaccine are quantitative, leaving room for exploratory investigations into reasons adults remain unvaccinated. This qualitative study assessed motivations, beliefs, and perceptions individuals who have...
Even with increased prevalence of homelessness in the US, there is limited research that investigates circumstances can lead to homelessness. This lack understanding perpetuates inequities health and wellbeing, access basic necessities, effective prevention strategies meaningful policy changes.
ABSTRACT Background The first shelter-in-place (SIP) order in the United States was issued across six counties San Francisco Bay Area to reduce impact of COVID-19 on critical care resources. We sought assess this large-scale intervention emergency departments (ED) Marin County, California. Methods conducted a retrospective descriptive and trend analysis all ED visits California from January 1, 2018 May 4, 2020 quantify temporal dynamics utilization before after March 17, SIP order. Results...
Abstract Aims West Nile Virus (WNV) has remained a persistent source of vector‐borne disease risk in California since first being identified the state 2003. The geographic distribution WNV activity is relatively widespread, but varies considerably across different regions within state. Spatial variation human infection depends upon social‐ecological factors that influence mosquito populations and virus transmission dynamics. Measuring changes spatial patterns over time necessary for...