A5024724548- Neurological disorders and treatments
- BRCA gene mutations in cancer
- Ethics in Clinical Research
- Genomics and Rare Diseases
- Autism Spectrum Disorder Research
- Neuroethics, Human Enhancement, Biomedical Innovations
- Prenatal Screening and Diagnostics
- Biomedical Ethics and Regulation
- Obsessive-Compulsive Spectrum Disorders
- Genetics and Neurodevelopmental Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Genomic variations and chromosomal abnormalities
- Neuroscience and Neural Engineering
- Reproductive Health and Technologies
- Psychosomatic Disorders and Their Treatments
- Ethics and Legal Issues in Pediatric Healthcare
- Digital Mental Health Interventions
- Assisted Reproductive Technology and Twin Pregnancy
- Adolescent and Pediatric Healthcare
- Memory and Neural Mechanisms
- Healthcare Decision-Making and Restraints
- Genetic Neurodegenerative Diseases
- CRISPR and Genetic Engineering
- Transcranial Magnetic Stimulation Studies
- Psychology of Moral and Emotional Judgment
Center for Practical Bioethics
2022-2024
Harvard University
2021-2024
Massachusetts General Hospital
2021-2024
Baylor College of Medicine
2017-2021
Zucker Hillside Hospital
2021
Feinstein Institute for Medical Research
2021
Hebrew University of Jerusalem
2021
Hofstra University
2021
University of Rochester Medical Center
2020
Institute of Medical Ethics
2020
We estimate that 208,000 deep brain stimulation (DBS) devices have been implanted to address neurological and neuropsychiatric disorders worldwide. DBS Think Tank presenters pooled data determined expanded in its scope has applied multiple an effort modulate neural circuitry. The was founded 2012 providing a space where clinicians, engineers, researchers from industry academia discuss current emerging technologies logistical ethical issues facing the field. emphasis is on cutting edge...
Importance Polygenic embryo screening (PES) is a novel technology that estimates the likelihood of developing future conditions (eg, diabetes or depression) and traits height cognitive ability) in human embryos, with goal selecting which embryos to use. Given its commercial availability concerns raised by researchers, clinicians, bioethicists, professional organizations, it essential inform key stakeholders relevant policymakers about public’s perspectives on this technology. Objective To...
Active avoidance (AA) is an important paradigm for studying mechanisms of aversive instrumental learning, pathological anxiety, and active coping. Unfortunately, AA neurocircuits are poorly understood, partly because behavior highly variable reflects a competition between Pavlovian reactions actions. Here we exploited the behavioral differences good poor avoiders to elucidate neurocircuit. Rats received Sidman training expression activity-dependent immediate-early gene c-fos was measured...
Psychiatry is rapidly adopting digital phenotyping and artificial intelligence/machine learning tools to study mental illness based on tracking participants' locations, online activity, phone text message usage, heart rate, sleep, physical more. Existing ethical frameworks for return of individual research results (IRRs) are inadequate guide researchers when, if, how this unprecedented number potentially sensitive about each participant's real-world behavior. To address gap, we convened an...
The Deep Brain Stimulation (DBS) Think Tank XI was held on August 9–11, 2023 in Gainesville, Florida with the theme of “Pushing Forefront Neuromodulation”. keynote speaker Dr. Nico Dosenbach from Washington University St. Louis, Missouri. He presented his research recently published Nature inn a collaboration Evan Gordon to identify and characterize somato-cognitive action network (SCAN), which has redefined motor homunculus led new hypotheses about integrative networks underpinning...
Abstract Patient narratives from two investigational deep brain stimulation trials for traumatic injury and obsessive‐compulsive disorder reveal that illness rob individuals of personal identity neuromodulation can restore it. The early success these interventions makes a compelling case continued post‐trial access to technologies. Given the centrality respect persons, failure provide be understood represent metaphorical theft. Such loss recapitulates pain an individual's initial or becomes...
Clinical trial participants who benefit from experimental neural devices for the treatment of debilitating and otherwise treatment-resistant conditions are generally not ensured continued access to effective therapy or maintenance at conclusion trials.
Artificial intelligence (AI)-based computer perception technologies (e.g., digital phenotyping and affective computing) promise to transform clinical approaches personalized care in psychiatry beyond by offering more objective measures of emotional states behavior, enabling precision treatment, diagnosis, symptom monitoring. At the same time, passive continuous nature which they often collect data from patients non-clinical settings raises ethical issues related privacy self-determination....
Importance: Current approaches to functional outcome assessment in persons with severe traumatic brain injury (TBI) may not reflect the perspectives of TBI or caregivers. Objective: Determine lowest level recovery after that is perceived be acceptable by and Design: Cross-sectional crowdsourcing online survey disseminated May-July 2024. Setting: United States. Participants: Persons a history requiring assistance basic daily activities Exposure(s): History TBI. Outcome(s)/Measure(s): An...
Interest and investment in closed-loop or adaptive deep brain stimulation (aDBS) systems have quickly expanded due to this neurotechnology's potential more safely effectively treat refractory movement psychiatric disorders compared conventional DBS. A large neuroethics literature outlines ethical concerns about DBS aDBS systems. Few studies, however, examined stakeholder perspectives issues research other next-generation devices. To help fill gap, we conducted semi-structured interviews with...
The annual Deep Brain Stimulation (DBS) Think Tank aims to create an opportunity for a multidisciplinary discussion in the field of neuromodulation examine developments, opportunities and challenges field. proceedings Sixth Annual recapitulate progress applications neurotechnology, neurophysiology emerging techniques treatment range psychiatric neurological conditions including Parkinson's disease, essential tremor, Tourette syndrome, epilepsy, cognitive disorders, addiction. Each section...
The literature on deep brain stimulation (DBS) and adaptive DBS (aDBS) raises concerns that these technologies may affect personality, mood, behavior. We conducted semi-structured interviews with researchers (n = 23) involved in developing next-generation systems, exploring their perspectives ethics policy topics including whether DBS/aDBS can cause such changes. majority of reported being aware or behavioral (PMB) changes recipients DBS/aDBS. Researchers offered varying estimates the...
BackgroundThere has been substantial controversy in the neuroethics literature regarding extent to which deep brain stimulation (DBS) impacts dimensions of personality, mood, and behavior.Objective/Hypothesis: Despite extensive debate theoretical literature, there remains a paucity empirical data available support or refute claims related psychosocial changes following DBS.MethodsA mixed-methods approach was used examine perspectives patients who underwent DBS their authenticity, autonomy,...
Abstract Although glutamate receptor 1 (GluR1)‐containing α‐amino‐3‐hydroxyl‐5‐methyl‐4‐isoxazole‐propionate receptors (GluR1‐AMPARs) are implicated in synaptic plasticity, it has yet to be demonstrated whether endogenous GluR1‐AMPARs undergo activity‐dependent trafficking vivo synapses support short‐term memory (STM) formation. The paradigm of pavlovian fear conditioning (FC) can used address this question, because a discrete region—the lateral amygdala (LA)—has been shown unambiguously...
Advances in genomics have led to calls for developing population-based preventive genomic sequencing (PGS) programs with the goal of identifying genetic health risks adults without known risk factors. One critical issue minimizing harms and maximizing benefits PGS is determining kind degree control individuals should over generation, use, handling their information. In this article we examine whether offer opportunity selectively opt out or analysis specific conditions (the menu approach) be...