A5051711446- Multiple Sclerosis Research Studies
- Inflammatory Myopathies and Dermatomyositis
- Peripheral Neuropathies and Disorders
- Polyomavirus and related diseases
- Muscle Physiology and Disorders
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Immunotherapy and Immune Responses
- Parkinson's Disease and Spinal Disorders
- Myasthenia Gravis and Thymoma
- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Systemic Sclerosis and Related Diseases
- Sphingolipid Metabolism and Signaling
- Autoimmune and Inflammatory Disorders Research
- Eosinophilic Disorders and Syndromes
- Cancer-related molecular mechanisms research
- COVID-19 Clinical Research Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Retinal and Optic Conditions
- Cell Adhesion Molecules Research
- Genetic Neurodegenerative Diseases
- Rheumatoid Arthritis Research and Therapies
- T-cell and B-cell Immunology
- Ophthalmology and Eye Disorders
University of the Sacred Heart
2025
Università Cattolica del Sacro Cuore
2014-2024
Agostino Gemelli University Polyclinic
2016-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2024
University of Verona
2024
Ospedale Policlinico San Martino
2022
Multiple Sclerosis Society
2022
University of Genoa
2022
Don Carlo Gnocchi Foundation
2018
Nini Hospital
2018
Mutations in the gene encoding fused-in-sarcoma (FUS) have been identified a subset of patients with sporadic and familial amyotrophic lateral sclerosis (ALS). Variants 3' untranslated region (3'UTR) FUS also reported ALS patients, but their pathogenic role has not assessed. We sequenced whole 3'UTR 420 who were negative for mutations currently known genes 480 ethnically matched controls. detected four variants (c.*48 G>A, c.*59 c.*108 C>T c.*110 G>A) one compared none controls (P = 0.02).We...
Objective To explore whether age at onset increased over time despite a shortened interval from the initial clinical demyelinating event to diagnosis of multiple sclerosis (MS), as promoted by updated diagnostic criteria. Methods This was an independent, multicentre, retrospective study based on data 4345 patients with relapsing-onset MS attending three tertiary Clinics in Italy. After stratifying year into four periods (<1991, 1991–2000, 2001–2010, 2011–2021), we analysed temporal trends...
<h3>Objective</h3> To assess long-term (2 years) effects of bimagrumab in participants with sporadic inclusion body myositis (sIBM). <h3>Methods</h3> Participants (aged 36–85 who completed the core study (RESILIENT [Efficacy and Safety Bimagrumab/BYM338 at 52 Weeks on Physical Function, Muscle Strength, Mobility sIBM Patients]) were invited to join an extension study. Individuals continued same treatment as (10 mg/kg, 3 1 mg/kg or matching placebo administered IV infusions every 4 weeks)....
The main aim of the study is to evaluate efficacy and safety profile ocrelizumab (OCR), rituximab (RTX), cladribine (CLA), employed as natalizumab (NTZ) exit strategies in relapsing-remitting multiple sclerosis (RRMS) patients at high-risk for progressive multifocal leukoencephalopathy (PML). This a multicentre, retrospective, real-world on consecutive RRMS from eleven tertiary Italian MS centres, who switched NTZ OCR, RTX, CLA January 1st, 2019, December 31st, 2019. primary outcomes were...
Abstract Several biomarkers from multiple sclerosis (MS) patients’ biological fluids have been considered to support diagnosis, predict disease course, and evaluate treatment response. In this study, we assessed the CSF concentration of selected molecules implicated in MS pathological process. To investigate diagnostic prognostic significance target candidate both relapsing (RMS, n = 107) progressive (PMS, 18) patients other inflammatory (OIND, 10) non-inflammatory (ONIND, 15) neurological...
<h3>Objective</h3> To directly compare fingolimod (FNG) and dimethyl fumarate (DMF) on no evident disease activity (NEDA) status in patients with relapsing-remitting multiple sclerosis (RRMS) from 7 outpatient clinics Central Italy. <h3>Methods</h3> We analyzed data of RRMS who started an oral agent, namely DMF or FNG, either as first treatment (naives) after switching self-injectable drugs (switchers). performed a propensity score (PS)–based nearest-neighbor matching within caliper 0.05 to...
In recent years, an autoantibody directed against the 5′-citosolic nucleotidase1A (cN1A) was identified in sera of sporadic inclusion body myositis (s-IBM) patients with widely variable sensitivity (33%–76%) and specificity (87%–100%). We assessed sensitivity/specificity anti-cN1A antibodies Italian cohort s-IBM patients, searching for a potential correlation clinical data. collected data from 62 consecutive other inflammatory myopathies patients. Testing performed using commercial ELISA....
In the pathogenesis of autoimmune disorders, modulation leukocytes' trafficking plays a central role, still poorly understood. Here, we focused on effect TLR2 ligands in T helper cells through reshuffling CD44 isoforms repertoire. Concurrently, strain background and haplotype affected Wnt/β-catenin signaling pathway expression splicing factors. During EAE, mCD44v9-v10 was specifically enriched forebrain showed an increased ability to bind stably osteopontin. Similarly, observed that hCD44v7...
Since February 2020, the outbreak of COVID-19 in Italy has forced health care system to undergo profound rearrangements its services and facilities, especially worst-hit areas Northern Italy. In this setting, inpatient outpatient had rethink reorganize their activities meet needs patients during "lockdown". The Italian Association Myology developed a survey estimate impact these changes on affected by neuromuscular disorders specialized centers acute phase pandemic.We an electronic that was...
Objective: Neurological sequelae of SARS-CoV-2 infection have already been reported, but there is insufficient data about the impact pandemic on management patients with chronic neurological diseases. We aim to analyze effect COVID-19 and social restriction rules these fragile patients. Methods: Patients neurologic diseases routinely followed at outpatient clinic Gemelli University Hospital, Rome, were assessed for symptoms suggestive in period, consequences restrictions, disease features,...
High-dose pulsed methylprednisolone-related liver injury cases have been reported in the literature, but a prospective study patients with multiple sclerosis (MS) has never performed. The aim of this was to evaluate prevalence and severity MS after methylprednisolone therapy.We performed observational single-center on treated i.v. 1,000 mg/day for 5 days. We tested functionality before 2 weeks treatment. In case severe injury, defined according "Hy's law," comprehensive hepatologic workup...
Recent studies estimated an incidence of 4–25% disease rebound after withdrawal fingolimod (FTY) for any reason, but specific data on reactivation FTY due to pregnancy are limited. The aim the study was evaluate frequency and predictors in patients who stopped pregnancy. A multicentre retrospective cohort conducted four Italian MS centres 2013–2019. Both planned unplanned pregnancies were included. annualized relapse rate (ARR) calculated before treatment, during year delivery. In total, 27...
To investigate the longitudinal dynamic of lymphocyte subsets during treatment with ocrelizumab (OCR) in patients multiple sclerosis (PwMS).A multicenter retrospective study was conducted 161 PwMS starting OCR grouped naive (naive, n = 40), switching from fingolimod (FTY, 52), and other immunomodulating drugs (other, 69). Mean subset (total, CD3+, CD4+, CD8+, CD20+, natural killer) counts were analyzed at baseline, 6 months, 12 months. Rate lymphocytopenia for each calculated all time points...
Background The assessment of treatment response is a crucial step for patients with relapsing-remitting multiple sclerosis on disease-modifying therapies (DMTs). We explored whether scoring system developed within the MAGNIMS (MRI in Multiple Sclerosis) network to evaluate injectable drugs can be adopted also oral DMTs. Methods A multicentre dataset 1200 who started three DMTs (fingolimod, teriflunomide and dimethyl fumarate) was collected network. Disease activity after first year...