A5005900658- Multiple Sclerosis Research Studies
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Optical Imaging and Spectroscopy Techniques
- Systemic Lupus Erythematosus Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced MRI Techniques and Applications
- Wound Healing and Treatments
- Cell Image Analysis Techniques
- Visual perception and processing mechanisms
- Dementia and Cognitive Impairment Research
- Glaucoma and retinal disorders
- Scoliosis diagnosis and treatment
- Peripheral Neuropathies and Disorders
- Mesenchymal stem cell research
- Ocular Diseases and Behçet’s Syndrome
- Vestibular and auditory disorders
- Advanced Fluorescence Microscopy Techniques
Hadassah Medical Center
2015-2021
Hebrew University of Jerusalem
2016-2021
Humboldt-Universität zu Berlin
2020
Charité - Universitätsmedizin Berlin
2020
Freie Universität Berlin
2020
University of California, Irvine
2020
National Multiple Sclerosis Society
2018
In this study (trial registration: NCT02166021), we aimed to evaluate the optimal way of administration, safety and clinical efficacy mesenchymal stem cell (MSC) transplantation in patients with active progressive multiple sclerosis. Forty-eight (28 males 20 females) sclerosis (Expanded Disability Status Scale: 3.0-6.5, mean : 5.6 ± 0.8, age: 47.5 12.3) evidence either worsening or activity during previous year, were enrolled (between 2015 2018). Patients randomized into three groups treated...
Clinical outcome in multiple sclerosis was suggested to be driven by not only remyelination but also adaptive reorganization. This mechanism needs further understood.To explore anatomical and functional visual networks patients with optic neuritis (ON) assess the relative weight of each connectivity modality expedite recovery.Between March 11, 2011, May 26, 2014, 39 either clinically isolated syndrome (CIS) ON (n = 18) or other CIS (non-ON) 21) were recruited 1 28 months following an initial...
Diffusion Tensor Imaging (DTI) can evaluate microstructural tissue damage in the optic radiation (OR) of patients with clinically isolated syndrome (CIS), early relapsing-remitting multiple sclerosis and neuromyelitis optica spectrum disorders (NMOSD). Different post-processing techniques, e.g. tract-based spatial statistics (TBSS) probabilistic tractography, exist to quantify this damage. To capacity TBSS-based atlas region-of-interest (ROI) combination 1) posterior thalamic ROIs from Johns...
Background: Over the last few years there has been growing interest in use of visual measures as useful tools for multiple sclerosis (MS) prognosis and tracking. Optic neuritis (ON) being a prevalent often-presenting symptom disease, well high occurrence rate posterior system damage independent ON (optic radiation lesions), make prime candidate such endeavors. However, while makes convenient model early stages MS, processes which may be true those drastically change disease progresses, due...
In developed countries, multiple sclerosis (MS) is the leading cause of non-traumatic neurological disability in young adults. MS a chronic demyelinating disease central nervous system, which myelin attacked, changing white matter structure and leaving lesions. The demyelination has direct effect on conductivity. This can be examined visual where damage highly prevalent MS, to substantial delays conduction, commonly measured with evoked potentials (VEPs). structural system often estimated...
To differentiate between visual cortical network topology changes following optic neuritis (ON) stemming from different inflammatory disease types, we used mathematical graph theory-based tools to analyze functional imaging data.Sixty-two patients were recruited into this cross-sectional study, 23 of whom had neuromyelitis optica spectrum disorder (NMOSD) with ON, 18 clinically isolated syndrome (CIS)-ON, and 21 other CIS episodes. Twenty-six healthy controls (HCs) also recruited. All...
Abstract The gradual accrual of disability over time in progressive multiple sclerosis is believed to be driven by widespread degeneration. Yet another facet the problem may reside loss brain's ability adapt damage incurred as disease progresses. In this study, we attempted examine whether changes associated with optic neuritis structural and functional visual networks can still discerned patients even years after acute insult. Forty‐eight patients, 21 27 without prior neuritis, underwent...
Objective: Evaluate impact of optic neuritis (ON) on visual cortical network using resting state functional connectivity MRI (RS-fcMRI). Background: In recent years, clinical outcome following an acute inflammatory attack in multiple sclerosis was suggested not only to be driven by tissue repair or remyelination but also influenced adaptive reorganization. Methods: 17 clinically isolated syndrome (CIS) ON patients and CIS non-ON underwent RS-fcMRI, optical coherence tomography (OCT),...
Objective: to examine whether past conclusions regarding dynamic visual functions in first-time optic neuritis (ON) patients hold advanced-stage MS with and without ON. Background: have been previously suggested better reflect the demyelinative damage caused nerve by a ON episode. Design/Methods: 48 patients, prior (N = 21, N nonON 27, time from episode > 7 years), underwent battery of static tests, as well VEP at two time-points, 66.1±10.4 days apart. Dynamic tests included...
Objective: To utilize diffusion tensor imaging (DTI) and resting state functional MRI (rsfMRI) to study the effect of localized gray matter damage on white networks integrity through model posterior cortical atrophy (PCA). Background: In contrary long-held beliefs, white-matter involvement in predominantly gray-matter diseases is well accepted. However, whether mechanism explain fibers’ degeneration or not dependent a debate. PCA neurodegenerative syndrome. The involved visual system also...
Objective: To study connectivity patterns within the visual cortex following optic neuritis (ON) and to test whether network behavior damage nerve is driven by disease type or form of disability. Background: We have previously shown that functional modification in clinically isolated ON (CIS-ON) patients may occur compensate for sustained affected nerve. Now, utilizing graph theory analysis methods we delve into individual regions system expand our include neuromyelitis optica spectrum...
To explore changing disparity (CD)-based motion-in-depth (MID) perception in optic neuritis (ON) patients and to evaluate its relationship inter-ocular delays.