A5087494074- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Neutropenia and Cancer Infections
- Transplantation: Methods and Outcomes
- Immunodeficiency and Autoimmune Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Mesenchymal stem cell research
- Eosinophilic Disorders and Syndromes
- Oral health in cancer treatment
- Blood groups and transfusion
- Horticultural and Viticultural Research
- Hematological disorders and diagnostics
- Erythrocyte Function and Pathophysiology
- Polyomavirus and related diseases
- Viral-associated cancers and disorders
- Head and Neck Cancer Studies
- Empathy and Medical Education
- Hemoglobinopathies and Related Disorders
- Blood disorders and treatments
- Childhood Cancer Survivors' Quality of Life
- Global Cancer Incidence and Screening
St. James's Hospital
2007-2024
Trinity College Dublin
2012-2024
Chelsea and Westminster Hospital
2016
European Hematology Association
2010-2013
John Wiley & Sons (United Kingdom)
2011
Institute of Technology Carlow
2011
Radboud University Nijmegen
2008
Radboud University Medical Center
2008
University of Basel
2008
European Society for Blood and Marrow Transplantation
1988-2006
Recent studies have shown that long-term survivors of acquired aplastic anemia may be at high risk for malignant diseases. We assessed the cancer after was treated with immunosuppression or bone marrow transplantation and sought to identify factors according treatment. The study population consisted 860 patients by 748 who had received transplants treatment severe anemia. analyzed overall relative in general population. In calculating risk, we excluded myelodysplastic syndromes acute...
This is an analysis of 509 patients with severe aplastic anaemia (SAA) treated in Europe between 1981 and 1986; 218 were by allogeneic bone marrow transplantation (BMT) from HLA identical sibling donors 291 immunosuppressive therapy (IS) antilymphocyte globulin (ALG). The overall actuarial survival was 63% after BMT 61% IS at 6 years. All fulfilled the criteria SAA; however, most a neutrophil count <0.2 × 10 9 /l also had infections haemorrhages. Therefore further subclassification...
The Prospective Oral Mucositis Audit assessed the incidence, duration, and determinants of severe oral mucositis (OM; WHO toxicity scale grades 3 to 4) in patients with multiple myeloma (MM) or non-Hodgkin's lymphoma (NHL) receiving high-dose conditioning chemotherapy before autologous stem-cell transplantation.Patients MM (n = 109; mean age, 57 +/- 8 years) NHL 88; 50 13 were treated melphalan (200 mg/m(2)) carmustine 300 mg/m(2), etoposide 800 cytarabine 1,600 140 mg/m(2) chemotherapy,...
The purpose of this guideline is to provide a rational approach the investigation and management patients with acquired aplastic anaemia. These guidelines have been produced by both specialists in field anaemia experienced district general hospital haematologists, reviewed members British Committee for Standards Haematology (BCSH) General Task Force. Because rare disease, many statements comments first part manuscript are based on review literature expert or consensus opinion rather than...
Summary This study was designed to determine the incidence of relapse and factors predictive for in 719 patients with severe aplastic anaemia (SAA) after immunosuppressive treatment (IS). Patients developing myelodysplasia or acute leukaemia IS, receiving a transplant, were excluded from this analysis. Response defined as reaching complete independence transfusions, becoming again transfusion dependent. criteria validated by similar figures when using other ‘relapse criteria’ such drop...
Summary 134 patients with acquired aplastic anaemia (AA) were given HALG 15 mg/kg/d for 5 d and methylprednisolone 1 month, randomized to receive ( n = 69) or not 65) oxymetholone 2 p.o. daily 4 months. Early mortality (<120 d) was comparable in the two arms 12/69 (17%) 11/65 (17%), correlated severity of disease (39%, 10% 6% respectively neutrophil counts (PMN) <0.2, 0.2–0.5, >0.5 × 10 9 /l). The response rate at 120 significantly greater receiving androgens (56% v 40%; P 0.04); it...
Summary Ninety‐one patients were studied serially for chimeric status following allogeneic stem cell transplantation (SCT) severe aplastic anaemia (SAA) or Fanconi Anaemia (FA). Short tandem repeat polymerase chain reaction (STR‐PCR) was used to stratify into five groups: (A) complete donor chimeras ( n = 39), (B) transient mixed 15) (C) stable 18), (D) progressive 14) (E) recipient with early graft rejection 5). As serial sampling not possible in Group E, chimerism results 86 available...
We have analyzed 2,002 patients grafted in Europe between 1976 and 1998 from an identical twin (n = 34), HLA-identical sibling 1,699) or alternative donor 269), which included unrelated family mismatched donors. The proportions of surviving these three groups are, respectively, 91, 66 37%: major causes failure were acute graft-versus host disease (GvHD) (11%), infection (12%), pneumonitis (4%), rejection (4%). In multivariate Cox analysis, factors predicting outcome patient’s age (p <...
Background. Increased risk of transplant related mortality in male recipients female hematopoietic stem cell grafts and vitro reactivity lymphocytes against H-Y encoded gene products females with rejected have been documented. An increased rejection is not reported for solid organ or transplants the role as transplantation antigen has controversial. Methods. Data from 1481 patients a aplastic anemia 154 centers 28 countries were analyzed. Outcome was compared between donors same opposite...
ACUTE leukemia after bone marrow transplantation for severe aplastic anemia is a rare event.1 , 2 In previous reports, such has been shown to originate in host cells.2 We report the development of acute monoblastic donor cells nine months patient with anemia. used cytogenetic analysis and novel application polymerase chain reaction (PCR) show that was donor-cell origin. The hematologically normal at time remained so this writing 18 later. Case Report A 19-year-old man presented . . .
Summary Chimaerism was assessed in five recipients following sex mismatched allogeneic bone marrow transplantation. Techniques included karyotyping of cells, dot blot DNA analysis blood and suspensions, vitro amplification by the polymerase chain reaction (PCR) using suspensions stored slides. Results karyotypic suggested complete chimaerism four patients, while one patient mixed detected. Mixed also detected, however, a second PCR confirmed on all tissues examined. is sensitive tool for...
In this single centre study of childhood acute lymphoblastic leukaemia (ALL) patients treated on the Medical Research Council UKALL 97/99 protocols, it was determined that minimal residual disease (MRD) detected by real time quantitative polymerase chain reaction (RQ-PCR) and 3-colour flow cytometry (FC) displayed high levels qualitative concordance when evaluated at multiple time-points during treatment (93.38%), a combined use both approaches allowed multi time-point evaluation MRD...
Abstract Objectives To measure the psychological effect of an art intervention on hospitalized patients and explore benefits to their quality life. Methods We conducted a large prospective randomized trial between July 2006 August 2009 intervention, Open Window (OW), in undergoing stem cell transplantation for hematological malignancy compared with control group. The primary endpoint measured levels anxiety, depression, stress using Hospital Anxiety Depression Scale Distress Thermometer....
Between August 1989 and November 2003, 33 patients at our center with acquired aplastic anemia underwent bone marrow transplantation (BMT) from HLA-identical sibling donors cyclophosphamide in vivo anti-CD52 monoclonal antibodies (MoAb) for conditioning. The median age BMT was 17 years (range, 4-46 years). Before BMT, 58% were heavily transfused (>50 transfusions), 42% had previously experienced treatment failure antithymocyte globulin-based immunosuppressive therapy. Unmanipulated used as...