A5089230954- Advanced MRI Techniques and Applications
- Chronic Myeloid Leukemia Treatments
- Empathy and Medical Education
- Genetic diversity and population structure
- Animal Ecology and Behavior Studies
- Chronic Lymphocytic Leukemia Research
- Sarcoma Diagnosis and Treatment
- Electron Spin Resonance Studies
- Ultrasound and Hyperthermia Applications
- Neonatal Respiratory Health Research
- Innovations in Medical Education
- Wildlife Ecology and Conservation
- Cerebral Venous Sinus Thrombosis
- Restraint-Related Deaths
- Neuroscience of respiration and sleep
- Erythropoietin and Anemia Treatment
- Multiple Sclerosis Research Studies
- Blood transfusion and management
- Vascular Tumors and Angiosarcomas
- Functional Brain Connectivity Studies
- NMR spectroscopy and applications
- Chemotherapy-induced organ toxicity mitigation
- Multiple Myeloma Research and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
UPMC Health System
2025
Dalhousie University
2001-2024
Saint John Regional Hospital
2024
Northwick Park Hospital
2021
King's College London
2017
King's College Hospital NHS Foundation Trust
2017
Creative Commons
2016
University College London
2005-2015
The Royal Free Hospital
2005-2015
National University Cancer Institute, Singapore
2010
Abstract We have used the CPMG pulse sequence to measure proton T 2 values and water content in spinal cord brain samples from Hartley guinea pigs inoculated produce experimental allergic encephalomyelitis (EAE). Relaxation data were fitted using minuit , a non‐linear curve fitting routine. Three exponentials provided best fit (10 ms (13%), 76 (57%), 215 (30%)) two for tissue (4%), 92 (96%)). Least squares algorithms also analyse terms of discrete smooth distributions relaxation times. The...
The ketogenic diet has demonstrated good efficacy in children with pharmacologically resistant seizures. Relatively few serious complications have been reported the more than 70 years which used. We report a child who developed acute pancreatitis and died. A 9-year-old girl had seizure disorder associated developmental delay owing to glucose transport protein deficiency. medium chain triglyceride oil initiated shortly after diagnosis infancy. She was not on anticonvulsants. presented coma...
Abstract Magnetic resonance (MR) imaging can be used to monitor the development of thermal lesions induced in tissue using interstitial laser photocoagulation (ILP). A potential application for ILP is treatment surgically inaccessible brain tumors. For successful clinical MR‐monitored ILP, it necessary relate MR images actual lesions. In this preliminary study we performed normal brains anesthetized cats by delivering interstitially 1.0, 1.5, and 2.0 W continuous‐wave Nd:YAG energy (1,064...
Interest has developed in using magnetic resonance (MR) imaging to monitor the volume of tissue destroyed by interstitial laser photocoagulation (ILP). In these experiments, ILP was induced normal brains 9 anesthetized cats delivering 1.5 W continuous-wave Nd:YAG energy (1,064 nm) from a single 400-microns core optical fiber for 1,000 s. The irradiations were monitored proton spin-echo MR during and immediately after at postirradiation survival times 2, 5, 14 days. At 2 days postirradiation,...
Abstract Background Shorter antibiotic courses are non-inferior to longer for treatment of uncomplicated gram-negative bacteremia (GNB). This study evaluated the impact a pharmacist-driven stewardship effort use clinical decision support software (CDSS; ILÚM Insight, Infectious Diseases Connect, Inc.) plus an evidence-based algorithm on duration therapy (DOT) GNB in UPMC health system, USA. Methods retrospective cohort utilized CDSS alerts Enterobacterales adults from March August 2022...
Estimating the rate and scale of dispersal is essential for predicting dynamics fragmented populations, yet empirical estimates are typically imprecise often negatively biased. We maximized detection events between small, subdivided populations water voles (Arvicola terrestris) using a novel method that combined direct capture-mark-recapture with microsatellite genotyping to identify parents offspring in different hence infer dispersal. validated individuals known from trapping data have...
Abstract Aim To characterize the presenting features and outcomes in children with seronegative autoimmune encephalitis, to evaluate whether scores at nadir for Modified Rankin Scale (mRS) Clinical Assessment Autoimmune Encephalitis (CASE) or its paediatric‐specific modification (ped‐CASE) are predictive of outcomes. Method This observational study included younger than 18 years age encephalitis. Demographics clinical data were collected. The mRS CASE/ped‐CASE used disease severity....
Abstract Objective To determine the bone mineral density (BMD) status of our juvenile dermatomyositis (DM) population and to compare frequency osteopenia in patients with active disease requiring corticosteroids that inactive who are not receiving corticosteroids. Methods Medical charts all children diagnosed as having DM at institution between 1989 1999 were reviewed for demographic clinical data, including activity duration corticosteroid therapy. BMD measurements lumbar spine (L1–L4)...
Abstract The phylogeographic pattern of mitochondrial DNA variation in water voles ( Arvicola terrestris ) from 57 localities across the United Kingdom and representative samples Spain, France, Switzerland Finland was determined sequence central portion control region. Twenty‐seven different haplotypes were resolved which formed two distinct phylogenetic clades. This major division separated found Scotland those England Wales. Nested clade analysis indicated that such a consequence...
The genetic structure of nine colonies the water vole, Arvicola terrestris, in one area NE Scotland was studied. Non-destructive samples from 478 individuals (mostly immature animals) were typed for 12 microsatellites. Cases Hardy-Weinberg disequilibrium frequent within all colonies. five inland part study also showed cases linkage disequilibrium. All high levels diversity (unbiased H = 0.52-0.74). sampled successive years significant annual changes composition. differentiation each other,...
A magnetic resonance scanner has been used to obtain images at 0.14 T, based on the water in aspen (Populustremuloides Michx.). In addition visualization of expected structural features such as annual growth-rings and knots, several additional appear that require further study. Kiln-dried wood does not contain sufficient give an image, but can do so after impregnation with water.
Case-informed learning is an umbrella term we use to classify pedagogical approaches that text-based cases for learning. Examples include Problem-Based, Case-Based, and Team-Based approaches, amongst others. We contend the at heart of case-informed are philosophical artefacts reveal traditional positivist orientations medical education medicine, more broadly, through their centering scientific knowledge objective fact. This orientation, however, leads absence human experience medicine in...
The incidence of respiratory depression following treatment prolonged seizures with benzodiazepines is variable in the literature. We retrospectively reviewed charts children treated for seizure over a one year period. Of 56 treated, 30 received lorazepam, 19 diazepam, and seven both drugs. Twenty two episodes (39%) were multiple doses benzodiazepines. In eight events (14%), there was documented administration or more benzodiazepine; six these, given. used often at low end less than...
Hidden knots and regions of decay in aspen (Populustremuloides Michx.) sample are highlighted using the nuclear magnetic resonance imaging technique. The images were obtained on a whole-body scanner that operates at 0.14 T for protons. water different responds differently, thereby imparting this useful information.
Journal Article MAGNETIC RESONANCE IMAGING OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN PRIMATES Get access W. A. STEWART, STEWART 1MRI Facility University of GuelphGuelph, Ontario, Canada Correspondence to: Dr W.A. Stewart, Magnetic Imaging Facility, Guelph, NIG 2WI. Search for other works by this author on: Oxford Academic PubMed Google Scholar E. C. ALVORD, JR, JR 2Department Pathology WashingtonSeattle, USA S. HRUBY, HRUBY L. D. HALL, HALL 3Department ChemistryVancouver, BC, PATY...