A5034189865- Global Cancer Incidence and Screening
- Cervical Cancer and HPV Research
- Reproductive tract infections research
- COVID-19 and healthcare impacts
- Endometrial and Cervical Cancer Treatments
- Genital Health and Disease
- Colorectal Cancer Screening and Detection
- Health Promotion and Cardiovascular Prevention
- Economic and Financial Impacts of Cancer
Erasmus MC
2020-2024
Erasmus University Rotterdam
2020
Many breast, cervical, and colorectal cancer screening programmes were disrupted due to the COVID-19 pandemic. This study aimed estimate effects of five restart strategies after disruption on required capacity burden.Microsimulation models simulated for screening. The estimated capacity, incidence, cancer-specific mortality a 6 months. varied in whether screens caught up or not and, if so, immediately delayed, upper age limit was increased.The without catch-up missed led an increase 2.0,...
Abstract Background: In the Netherlands, lower high-risk human papillomavirus (hrHPV) positivity but higher cervical intraepithelial neoplasia (CIN) 2+ detection were found in self-collected compared with clinician-collected samples. To investigate possible reason for these differences, we sociodemographic and screening characteristics of women related to outcomes. Methods: We extracted data from PALGA on all primary hrHPV screens associated follow-up tests 857,866 screened women, invited...
With the implementation of primary high-risk human papillomavirus (hrHPV) screening in Netherlands, an increase was observed number unnecessary referrals (≤Cervical Intraepithelial Neoplasia (CIN) 1) to colposcopy. We aimed investigate which alternative triage strategies safely reduce HPV-based cervical cancer programmes.Microsimulation model MISCAN used simulate unvaccinated cohort ten million 30-year old Dutch women. calculated referrals, incidence, mortality, costs and QALYs for 24...
Declining attendance in the Dutch cervical cancer screening programme was recently observed, coinciding with preparations for implementing primary hrHPV-based screening, which implemented January 2017. We aimed to investigate factors were related decreased attendance. conducted a population-based cohort study including all women aged 30 60 years who eligible between 2014 and 2018. Attendance defined as participation within 15 months of start invitation-eligible year. used data from pathology...
Abstract Background Human papillomavirus (HPV) vaccination and intensifying screening expedite cervical cancer (CC) elimination, yet also deteriorate the balance between harms benefits of screening. We aimed to find strategies that eliminate CC rapidly but maintain an acceptable harms-benefits ratio Methods Two microsimulation models (STDSIM MISCAN) were applied simulate HPV transmission for Dutch female population 2022 2100. estimated elimination year ratios 228 unique scenarios varying in...
To calculate the changes in harms and benefits of cervical cancer screening over first three rounds Dutch high-risk human papillomavirus (hrHPV) programme.Microsimulation study.Dutch hrHPV programme; women are invited for every 5 or 10 years (depending on age history) from 30 to 65.Partly vaccinated population 100 million women.Microsimulation model MISCAN was used estimate effects. Sensitivity analyses were performed test characteristics attendance.Harms (screening tests, unnecessary...
ABSTRACT Background Computer‐assisted screening (CAS) shows equal performance compared to manual screening, although results are heterogeneous. Furthermore, using CAS may save costs through a potentially increased productivity of technicians, therefore also offering solution for temporary and structural capacity shortage. We evaluated the circumstances under which will be cost‐effective cytology triage in primary HPV‐based cervical programme. Methods Microsimulation model MISCAN‐Cervix was...