A5091030151- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Infant Nutrition and Health
- Preterm Birth and Chorioamnionitis
- Neonatal and Maternal Infections
- Respiratory viral infections research
- Neonatal Health and Biochemistry
- Sarcoma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Gut microbiota and health
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Immune Response and Inflammation
- Skin and Cellular Biology Research
- Pediatric Hepatobiliary Diseases and Treatments
- 14-3-3 protein interactions
- Pneumonia and Respiratory Infections
- Neuroscience of respiration and sleep
- Pregnancy and preeclampsia studies
- Medical Imaging and Pathology Studies
- Hematopoietic Stem Cell Transplantation
- Dermatological and Skeletal Disorders
- Testicular diseases and treatments
- Signaling Pathways in Disease
- Child and Adolescent Health
- Galectins and Cancer Biology
University of Lübeck
2010-2024
Universitäres Kinderwunschzentrum Lübeck
2015-2024
University Hospital Schleswig-Holstein
2020-2024
Klinik und Poliklinik für Kinder- und Jugendmedizin
2023
Cincinnati Children's Hospital Medical Center
2021-2022
University of Cincinnati Medical Center
2021-2022
German Center for Infection Research
2021
Abstract The German Neonatal Network (GNN) is a prospective cohort study with the focus on long term development of very-low-birth-weight infants. It was aim this to determine detailed information causes mortality in GNN birth 2010. Major contributors hospital were recorded by attending neonatologists for (VLBW) infants born centres data quality approved on-site monitoring. 2 221 VLBW 2010, and death occurred Male carried higher risk than females (58.8% males among non-survivors vs. 51.7%...
Regulatory T cells (Tregs) are important for the ontogenetic control of immune activation and tissue damage in preterm infants. However, role Tregs development bronchopulmonary dysplasia (BPD) is yet unclear. The aim our study was to characterize CD4+ CD25+ forkhead box protein 3 (FoxP3)+ peripheral blood well-phenotyped infants (n =382; 23 + 0 - 36 6 weeks gestational age) with a focus on first 28 days life clinical endpoint BPD (supplemental oxygen longer than age). In subgroup infants, we...
Animal models imply that the perinatal exposure to antibiotics has a substantial impact on microbiome establishment of offspring. We aimed evaluate effect timing antimicrobial prophylaxis for cesarean section before versus after cord clamping gut composition term born infants. performed an exploratory, single center randomized controlled clinical trial. included forty pregnant women with elective at term. The intervention group received dose intravenous cefuroxime (n = 19), control 30...
Perinatal inflammatory stress is associated with early life morbidity and lifelong consequences for pulmonary health. Chorioamnionitis, an condition affecting the placenta fluid surrounding developing fetus, affects 25 to 40% of preterm births. Severe chorioamnionitis birth significantly increased risk disease secondary infections in childhood, suggesting that fetal inflammation may markedly alter development lung. Here, we used intra-amniotic lipopolysaccharide (LPS) challenge induce...
In recent years galectin-3 has gained attention as a signalling molecule, mainly in inflammatory diseases. Data on expression neonates, however, are limited, and of this lectin cord blood not yet been reported. The aim study was to determine levels term preterm neonates well after stimulation with the prevalent pathogen Streptococcus agalactiae. Cord samples were incubated for 24 h assessed by enzyme-linked immunosorbent assay. There is positive correlation between gestational age blood....
Abstract In contrast to transplant recipients, there is a paucity of data regarding frequency and clinical significance viraemia in children receiving conventional chemotherapy. prospective observational study, we assessed the impact with cytomegalovirus (CMV), Epstein-Barr virus (EBV), adenovirus, human herpesvirus-6 (HHV6) herpes-simplex 1/2 (HSV1/2) paediatric cancer patients at diagnosis, routine examination during intensive chemotherapy, febrile neutropenia (FN). Seventy-nine (median...
Objective To provide epidemiological data of infants < 90 days age with suspected late-onset sepsis (LOS) and evaluate distinct immunological specificities. We hypothesized that previously healthy 3 months have a yet undefined predisposition; e.g. differences in lymphocyte subsets including regulatory T cells. Methods performed an exploratory, single center study between January 1 st , 2019 June 2021. Routine diagnostics included conventional culture (blood, cerebrospinal fluid,...
Up to 40% of preterm births are associated with histological chorioamnionitis (HCA), which leads elevated levels pro-inflammatory mediators and microbial products in the amniotic fluid, come contact fetal lungs. Yet, pulmonary immune responses such exposure remain poorly characterized. To address this gap, we used our established HCA model, pregnant Rhesus macaques receive intraamniotic (IA) saline or LPS. IA LPS induced a potent rapid myeloid cell response lungs, dominated by neutrophils...
Hintergrund Pneumonien gehören zu den häufigsten Infektionen im Kindesalter. Bei schweren Verläufen mit stationärer Aufnahme wird häufig eine Bildgebung durchgeführt. Das radiologische Bild ist vielfältig und lässt kaum Rückschlüsse auf die Genese zu.
Abstract Background Effective local therapy (surgery, radiation) and systemic multidrug chemotherapy are mandatory for curing childhood sarcoma. The standard radiation pediatric patients with soft‐tissue sarcoma (STS) is external beam radiotherapy (EBRT). Because EBRT may cause long‐term side effects adverse on the patients’ health quality of life (QoL), alternative strategies required. Interventional (IRT; brachytherapy) established as a treatment several tumors in adulthood. Single‐center...
Abstract Intrauterine inflammation/infection (IUI), which is present in up to 40% of premature births, leads elevated levels pro-inflammatory mediators and microbial products within the amniotic fluid, come close contact fetal mucosae. Yet, knowledge on mucosal responses IUI exposure remains limited. To address these questions, we used a non-human primate model IUI, pregnant Rhesus macaques received intra-amniotic (IA) LPS, compared with IA saline. We found that LPS induced robust rapid...
Abstract Malformations of or injuries to the developing lung are associated with perinatal morbidity and mortality lifelong consequences for subsequent pulmonary health. One fetal exposure linked poor health outcomes is chorioamnionitis, which impacts up 25-40% preterm births. Severe chorioamnionitis prematurity significantly increased risk disease secondary infections in childhood, suggesting that inflammation may alter developmental ontogeny lung. To test this hypothesis, we used...
Introduction: Soft tissue sarcomas represent the third most solid tumors in pediatric patients besides CNS and neuroblastomas. Local therapy is mandatory for cure of malignant soft tumors. Along with surgery radiation constitutes an important part local therapy. Brachytherapy has significant advantages over common We analysed all children undergoing brachytherapy sarcoma Lübeck within past 20 years compared event free survival overall these patient historical controls.
Einleitung Kommt es bei intensiv vorbehandelten pädiatrisch-onkologischen Patienten unter oder nach Therapie zum Auftreten von respiratorischen Beschwerden, so erfordert dies eine gewissenhafte Differenzialdiagnostik. Insbesondere opportunistische Infektionen aber auch seltene Lungenerkrankungen müssen hierbei berücksichtigt werden.
Die moderne Neonatalogie hat, nicht zuletzt seit der Einführung Surfactanttherapie, viele Fortschritte bezüglich des Überlebens auch extrem frühgeborener Kinder gemacht. Daten zu aktuellen Mortalitätsrisiken Allerkleinsten sind rar. Das Deutsche Frühgeborenennetzwerk (GNN) veröffentlichte jetzt, was extreme Frühchen derzeit am meisten gefährdet.