A5064884634- Neuroscience and Neuropharmacology Research
- Media Studies and Communication
- Neurogenesis and neuroplasticity mechanisms
- Memory and Neural Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Media, Gender, and Advertising
- Neurobiology of Language and Bilingualism
- Neurotransmitter Receptor Influence on Behavior
- Barrier Structure and Function Studies
- Humor Studies and Applications
- Lipid Membrane Structure and Behavior
- Mitochondrial Function and Pathology
- Nerve injury and regeneration
- Alzheimer's disease research and treatments
- Breast Cancer Treatment Studies
- Neuroendocrine regulation and behavior
- Neuropeptides and Animal Physiology
- Media Influence and Health
- Diet and metabolism studies
- Gender, Feminism, and Media
- Traumatic Brain Injury and Neurovascular Disturbances
- Receptor Mechanisms and Signaling
- Ion channel regulation and function
- Public Relations and Crisis Communication
- Language Development and Disorders
University of Augsburg
2019-2022
Deutsche Montan Technologie (Germany)
2020
Heinrich Heine University Düsseldorf
2013-2019
University of Basel
2006-2016
University of Fribourg
2012
University of Bern
2001
Ludwig-Maximilians-Universität München
1986-1995
Universitäts Frauenklinik
1994
Krankenhaus Bethanien
1990-1993
University of Münster
1989
Abstract: At 1, 2, and 4 weeks after unilateral premotor motor cortex ablation in rats, a significant lasting decrease glutamate levels the ipsilateral versus contralateral striatum was observed. A corresponding fall aspartate seen only 1 week. In contrast, there large increase striatal concentrations of lysine, threonine, alanine, glutamine week cortical ablation. This correlates with extensive glial proliferation deafferented striatum. Four GABA concentration significantly increased. There...
Theories of eudaimonic entertainment and destigmatization concur to suggest that empathic feelings elicited by portrayals Paralympic athletes can increase audience interest in para-sports lead prosocial attitude change toward persons with disabilities general. Three experiments were conducted examine this dual, mutually reinforcing function empathy promoting public awareness destigmatization. Participants watched television spots about the Paralympics different levels empathy. As expected,...
Protease nexin-1 (PN-1), a member of the serpin superfamily, controls activity extracellular serine proteases and is expressed in brain. Mutant mice overexpressing PN-1 brain under control Thy-1 promoter (Thy 1/PN-1) or lacking (PN-1-/-) were found to develop epileptic vivo vitro. Theta burst-induced long-term potentiation (LTP) NMDA receptor-mediated synaptic transmission CA1 field hippocampal slices augmented Thy 1/PN-1 reduced PN-1-/- mice. Compensatory changes GABA-mediated inhibition...
A primary function of epithelial and endothelial monolayers is the formation barriers that separate tissues into functional compartments. Tight junctions (TJs) seal intercellular space between single cells a monolayer. TJs thus contribute importantly to homeostasis cerebrospinal fluid as they help in maintaining blood-brain barrier (BBB) blood-cerebrospinal (CSF). The composition differs by its localization well stage development according respective function. Claudin-3 typically present...
This study was performed to examine the maintenance of blood vessels in vitro cortical organotypic slice cultures mice with special emphasis on basic fibroblast growth factor (FGF-2), which is known promote angiogenesis and preserve integrity blood–brain barrier. Slices neonatal day 3 or 4 mouse brain were maintained for 3, 7, 10 d (DIV) under standard culture conditions presence FGF-2. Immunohistochemistry VIII-related antigen laminin revealed a relative low number conditions. In contrast,...
Isolated chromaffin granules incubated in 10 millimolar calcium chloride aggregated, forming contact sites with a pentalaminar membrane structure. These circular attachment were free of membrane-associated particles, which accumulated at the periphery. Incubation 20 ethylenediaminetetraacetic acid reversed these changes, are regarded as initial events fusion reaction.
Interrelationship between the breakdown of blood–brain barrier (BBB) to Evans blue and elevations in regional cerebral blood flow (rCBF) was studied rabbits subjected adrenaline- or metaraminol-induced systemic hypertension also bicuculline-induced seizures. The rCBF assessed small samples from various regions brain with use [ 3 H]nicotine, permeability BBB evaluated an tracer. In acute hypertension, extravasations were observed occipital cortex sometimes superior colliculus, i.e., which...
In the gravimetric method for estimation of water content in brain tissue, four factors that may affect specific gravity (SG) measurements are described and evaluated. These are: (1) purity kerosene (K) monobromobenzene (MBB), (2) duration interaction MBB with tissue and/or standard solutions, (3) size samples, (4) temperature. A water-soluble contaminant K, which can be effectively extracted by treatment, significantly decrease SO values. Conversely, MBB, SG samples tends to increase...
Abstract: The activities of the enzymes GABA system, glutamate decarboxylase (GAD) and GABA‐transaminase, were measured in discrete regions rabbit brain before onset during course sustained epileptiform seizures induced by vitamin B 6 , analogue methoxypyridoxine (MP). GAD a reaction mixture alternatively containing cofactor pyridoxal‐5′‐phosphate (PLP) excess or no PLP (holoenzyme GAD). A comparison between these two estimations showed that apoenzyme is only partially saturated with degree...
Modification by O-GlcNAc involves a growing number of eucaryotic nuclear and cytosolic proteins. Glycosylation intracellular proteins is dynamic process that in several cases competes with acts as reciprocal modification system to phosphorylation. O-Linked beta-N-acetylglucosamine transferase (OGT) levels are highest the brain, neurodegenerative disorders such Alzheimer disease have been shown involve abnormally phosphorylated key proteins, probably result hypoglycosylation. Here, we show...