A5017253744- Vector-borne infectious diseases
- Vector-Borne Animal Diseases
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Malaria Research and Control
- Entomopathogenic Microorganisms in Pest Control
- Insect symbiosis and bacterial influences
- Plant Virus Research Studies
- Insect and Pesticide Research
- Microbial infections and disease research
- Parasites and Host Interactions
- Parasitic infections in humans and animals
- Toxin Mechanisms and Immunotoxins
- Mycobacterium research and diagnosis
- Bacteriophages and microbial interactions
- Congenital Anomalies and Fetal Surgery
- Global Maternal and Child Health
- Transgenic Plants and Applications
- Animal Disease Management and Epidemiology
- Child Nutrition and Water Access
- Poverty, Education, and Child Welfare
- Parasitic Infections and Diagnostics
- Genomics and Phylogenetic Studies
- Insect Pest Control Strategies
- Seed Germination and Physiology
University of Nairobi
2015-2025
Kenyatta National Hospital
2025
Nairobi Hospital
2025
Jomo Kenyatta University of Agriculture and Technology
2015-2022
Kenya Medical Research Institute
2022
University of California, Irvine
2022
Case Western Reserve University
2022
Maseno University
2022
Kenyatta University
2022
Lee University
2022
A novel apicomplexan parasite was serendipitously discovered in horses at the United States – Mexico border. Phylogenetic analysis based on 18S rDNA showed erythrocyte-infective to be related to, but distinct from, Theileria spp. Africa, most similar taxa being from waterbuck and mountain zebra. The degree of sequence variability observed locus also suggests likely existence additional cryptic species. Among described species, genome this equid is that equi, a pathogen horses. estimated...
Summary At present, there is little information on the phylogenetic diversity of microbial species that inhabit gastrointestinal tracts wildlife. To increase understanding in this area, we initiated a characterization bacterial digestive three wild African ruminant namely eland ( Taurotragus oryx ), Thompson's gazelle Gazella rufifrons ) and Grant's granti together with domesticated species, zebu cattle Bos indicus non‐ruminant zebra Equus quagga ). Bacterial was analysed by PCR...
Background Theileria parva causes an acute fatal disease in cattle, but infections are asymptomatic the African buffalo (Syncerus caffer). Cattle can be immunized against parasite by infection and treatment, immunity is partially strain specific. Available data indicate that CD8+ T lymphocyte responses mediate protection and, recently, several antigens recognised cells have been identified. This study set out to determine nature extent of polymorphism two these antigens, Tp1 Tp2, which...
African Cape buffalo (Syncerus caffer) is the wildlife reservoir of multiple species within apicomplexan protozoan genus Theileria, including Theileria parva which causes East coast fever in cattle. A parasite, has not yet been formally named, known as sp. (buffalo) recognized a potentially distinct based on rDNA sequence, since 1993. We demonstrate using reverse line blot (RLB) and sequencing 18S genes, that an area where cattle co-graze there heavy tick challenge, T. can frequently be...
A cross-sectional study was conducted to determine the seroprevalence of Brucella spp. and Leptospira risk factors exposure in cattle three zones with varying land use types wildlife-livestock interactions. Five villages were selected purposively; two areas intensive livestock-wildlife interactions (zone 1), another moderate 2) one where are rarer 3). Sera samples collected from 1170 belonging 390 herds all tested for antibodies against abortus interrogans serovar hardjo using ELISA kits....
Livestock-wildlife interactions promote the transmission of a wide range infectious diseases that constraint livestock production. We used participatory appraisal approach to find out and rank concern pastoralists in zone intense wildlife-livestock interaction another with limited interactions. Four villages were selected purposively areas intensive cattle-wildlife (zone 1), two low moderate 2). Data collected focus group discussions (FGDs) using epidemiological methods (PE); each had 8-13...
A major risk factor for the spread of livestock diseases and their vectors is uncontrolled transboundary movement live animals trade grazing. Such movements constrain effective control tick-transmitted pathogens, including Theileria parva. Only limited studies have been undertaken to identify ticks tick-borne (TTBDs) affecting cattle in central African countries, Cameroon. We hereby report collection baseline data on prevalence T. parva Cameroon through a countrywide cross-sectional survey,...
There are no commercially available vaccines against human protozoan parasitic diseases, despite the success of vaccination-induced long-term protection infectious diseases. East Coast fever, caused by protist Theileria parva, kills one million cattle each year in sub-Saharan Africa, and contributes significantly to hunger poverty region. A highly effective, live, multi-isolate vaccine T. parva exists, but its component isolates have not been characterized. Here we sequence compare three...
Background Tungiasis is a parasitic disease caused by the sand flea Tunga penetrans also known as jigger flea. Communities living in precarious conditions tropical and sub countries bear brunt of infection. The main objective this study was to determine burden Vihiga County Kenya. Methods This cross-sectional conducted 21 villages 3 Sub-locations County, western A total 437 participants, 5 years old above were clinically examined for presence tungiasis after consenting take part study....
Rhipicephalus appendiculatus is the primary vector of Theileria parva, etiological agent East Coast fever (ECF), a devastating disease cattle in sub-Saharan Africa. We hypothesized that vaccine targeting tick proteins are involved attachment and feeding might affect success possibly reduce tick-borne transmission T. parva. Here we report evaluation multivalent cocktail antigens for their ability to R. tick-transmission parva natural host-tick-parasite challenge model. Cattle were inoculated...
Theileria parva is the etiologic agent of East Coast fever, an economically important disease cattle in sub-Saharan Africa. This protozoan parasite biologically transmitted by Rhipicephalus appendiculatus (Neumann) (Acari: Ixodidae). An understanding vector-parasite interaction may aid development improved methods for controlling transmission. We developed quantitative polymerase chain reaction (qPCR) and nested PCR (nPCR) assays targeting T. parva-specific p104 gene to study pathogenesis...
Tungiasis or jigger infestation is a parasitic disease caused by the female sand flea Tunga penetrans. Secondary infection of lesions this common in endemic communities. This study sought to shed light on bacterial pathogens causing secondary infections tungiasis and their susceptibility profiles commonly prescribed antibiotics. Participants were recruited with help Community Health Workers. Swabs taken from which showed signs infection. Identification suspected bacteria colonies was done...
All canine hookworms are known to be zoonotic, causing infections ranging from transient skin irritations prolonged 'creeping eruptions', eosinophilic enteritis and even patent intestinal infections. There is little information on hookworm species their public health significance in sub-Saharan Africa. This study determined the prevalence of dogs different climatic zones Kenya. Dog faecal samples were collected environment, eggs isolated by zinc chloride flotation subjected DNA extraction....