A5107995565- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Neonatal and fetal brain pathology
- Childhood Cancer Survivors' Quality of Life
- Non-Invasive Vital Sign Monitoring
- Optical Imaging and Spectroscopy Techniques
- Dialysis and Renal Disease Management
- Palliative Care and End-of-Life Issues
- Grief, Bereavement, and Mental Health
- Ethics and Legal Issues in Pediatric Healthcare
- Hemodynamic Monitoring and Therapy
- Child and Adolescent Health
- Congenital Diaphragmatic Hernia Studies
- Neonatal Health and Biochemistry
- Birth, Development, and Health
- Neuroscience of respiration and sleep
- Congenital Heart Disease Studies
- Pregnancy and preeclampsia studies
- Retinopathy of Prematurity Studies
- Respiratory Support and Mechanisms
- Erythropoietin and Anemia Treatment
- Cancer-related molecular mechanisms research
- Migration, Health and Trauma
- Pediatric Pain Management Techniques
- Preterm Birth and Chorioamnionitis
European Society for Paediatric Research
2024
University Hospital of Zurich
2015-2024
University of Zurich
2014-2024
Swiss Epilepsy Center
2022
See-Spital
2019
Olgahospital
2011
Universitäts Frauenklinik
2011
West Middlesex University Hospital
2009
Monash Medical Centre
1999-2003
Monash University
1999-2003
OBJECTIVE. Erythropoietin has been shown to be protective against hypoxic-ischemic and inflammatory injuries in cell culture, animal models of brain injury, clinical trials adult humans. The rationale for our study was that early administration high-dose recombinant human erythropoietin may reduce perinatal injury (intraventricular hemorrhage periventricular leukomalacia) very preterm infants improve neurodevelopmental outcome. We investigated whether shortly after birth subsequently during...
Abstract CD31 + CD45RA RO – lymphocytes contain high numbers of T cell receptor circle (TREC)‐bearing cells; however, the correlation between CD4 and TREC during aging under lymphopenic conditions has not yet been sufficiently investigated. We analyzed TREC, telomere length telomerase activity within sorted in healthy individuals from birth to old age. Sorted naive contained numbers, whereas cells (comprising ⩽5% aging) did TREC. overall remained rich despite an age‐related tenfold reduction...
<h3>Importance</h3> Very preterm infants are at risk of developing encephalopathy prematurity and long-term neurodevelopmental delay. Erythropoietin treatment is neuroprotective in animal experimental human clinical studies. <h3>Objective</h3> To determine whether prophylactic early high-dose recombinant erythropoietin (rhEPO) improves outcome 2 years' corrected age. <h3>Design, Setting, Participants</h3> Preterm born between 26 weeks 0 days' 31 6 gestation were enrolled a randomized,...
OBJECTIVE. Our goal was to investigate the effect of placentofetal transfusion on cerebral oxygenation in preterm infants by near-infrared spectroscopy. SUBJECTS. A total 39 with a median gestational age 30.4 weeks were randomly assigned an experiment group (n = 15) and control 24). INTERVENTIONS. The delivery immediately followed maternal administration syntocinon, infant placed 15 cm below placenta, cord clamping delayed 60 90 seconds. delivered conventionally. At ages 4 24 hours,...
To assess grief and post-traumatic growth in parents 2-6 years after the death of a premature baby (24-26 weeks' gestation) to evaluate Pictorial Representation Illness Self-Measure (PRISM) assessment bereavement.Fifty-four were assessed for their experiences during hospitalization by questionnaires regarding (MTS), growth, affective symptoms visual representation self (PRISM).Even loss extremely preterm infant still suffer lot from bereavement, mothers more so than fathers (Mann-Whitney U...
Fetal hemoglobin, HbF (α2γ2), is the main hemoglobin synthesized up to birth, but it subsequently declines and adult HbA (α2β2), becomes predominant. Several studies have indicated that expression of subunit γ-globin might be regulated post-transcriptionally. This could confered by ∼22-nucleotide long microRNAs associate with argonaute proteins specifically target mRNAs inhibit protein expression. Indeed, applying immunopurifications, we found mRNA was associated 2 isolated from...
In the last 20 years, chances for intact survival extremely preterm infants have increased in high income countries. Decisions about withholding or withdrawing intensive care remain a major challenge born at limits of viability. Shared decision-making regarding these fragile between health professionals and parents has become preferred model today. However, there is an ongoing ethical debate on how decisions life-sustaining treatment should be reached who final word when do not agree. We...
The aim of the study was to analyze neonatal impact a methadone maintenance program in pregnancy, and social resources families involved.Descriptive analysis data live births after 24 weeks gestation pregnant women enrolled program. 86 babies were analyzed.Median gestational age 38 (0)/(7) (31-41) weeks; 21 (24%) premature. Median birthweight 2662 (1340-4050) g; 27% growth retarded (<3rd centile), 13% had microcephaly centile). Sixty-two percent developed abstinence syndrome requiring...
Abstract Background : The increase in neonatal survival recent decades has been followed by an later disabilities. This given rise to many new ethical issues. In different countries, efforts are being made define guidelines regarding withholding or withdrawing intensive care and end‐of‐life decisions critically ill newborn infants. These have be differentiated from decision‐making models which structure the process of decision making for individual child. Such a framework existence our...
Early detection of cerebral hypoxemia is an important aim in neonatology. A relevant parameter to assess brain oxygenation may be the tissue oxygen saturation (StO2) measured by near-infrared spectroscopy (NIRS). So far reproducibility StO2 measurements was too low for clinical application, probably due inhomogeneities. The this study test a novel sensor geometry which reduces influence Thirty clinically stable newborn infants, with gestational age median 33.9 (range 26.9 41.9) weeks, birth...
Abstract Aim: To assess health‐related quality of life young adults born very preterm compared with a term control group. Methods: A cohort infants <1250 g and group, both between 1983 1985, were surveyed as at the median age 23 years. Questionnaires including Short Form 36 Health Survey (SF 36) modified lifestyle questionnaire assessed life, health attitudes, height weight, chronic diseases, medication drug consumption. Results: Fifty‐two preterms 75 controls matched for sex participated...
Medical personnel working in intensive care often face difficult ethical dilemmas. These may represent important sources of distress and lead to a diminished self-perceived quality eventually burnout.The aim this study was identify work-related assess symptoms burnout among physicians nurses Swiss neonatal units (NICUs).In summer 2015, we conducted an anonymous online survey comprising 140 questions about decisions concerning extremely preterm infants. Of these questions, 12 related 10...
This study reports 5-year neurodevelopmental outcomes for Swiss children born before 32 weeks' gestation and randomized at birth to receive early high-dose recombinant human erythropoietin (rhEpo) vs placebo.
We have designed a versatile, multi-channel near-infrared spectrophotometry (NIRS) instrument for the purpose of mapping neuronal activation in neonatal and adult brain response to motor, tactile, visual stimulation. The optical linearity, stability, high signal noise ratio (>70 dB) were demonstrated using an vitro validation procedure. In vivo measurements on forearm also performed. Changes oxygenation, induced by arterial occlusion forearm, recorded shown compare well with acquired...
Fifty-four appropriate for gestational age preterm infants (less than 35 weeks gestation) were followed prospectively from birth with coagulation and real-time ultrasound studies. Coagulation analyses included fibrinogen, prothrombin time, thrombin time platelet count. The occurrence of peri-intraventricular hemorrhage (PIVH) was documented by portable 5 MHz Echo Scanner. Definite PIVH present in 21 babies (38%). studies showed especially lower values fibrinogen levels less 30 gestation...
Abstract Background The gold standard to assess hyperbilirubinemia in neonates remains the serum bilirubin measurement. Unfortunately, this is invasive, painful, and costly. Bilimed ® , a new transcutaneous bilirubinometer, suggests more accuracy compared existing non-invasive bilirubinometers because of its technology. It furthermore takes into account different skin colours. No contact with needed during measurement, no additional material costs occur. Our aim was agreement between preterm...
Abstract This paper gives an overview of principles, technologies, and applications using near infrared spectrometry imaging (NIRS NIRI) to study brain function. The physical background is reviewed technologies their properties are discussed. Advantages limitations NIRI described. basic functional signals obtained by NIRI, the neuronal hemodynamic signal described in particular publications about former reviewed. Applications adults neonates reviewed, too.
Abstract Non-invasive cardiac output monitoring, via electrical biosensing technology (EBT), provides continuous, multi-parameter hemodynamic variable monitoring which may allow for timely identification of instability in some neonates, providing an opportunity early intervention that improve neonatal outcomes. EBT encompasses thoracic (TEBT) and whole body (WBEBT) methods. Despite the lack relative accuracy these technologies, as compared to transthoracic echocardiography, use technologies...
Importance Children born very preterm are at risk for long-term neurodevelopmental sequelae. Prophylactic high-dose recombinant human erythropoietin (rhEpo) shortly after birth has not been shown to improve cognitive, motor, and behavioral development 2 5 years. Objective To investigate whether early rhEpo is associated with better executive functions processing speed—late-maturing cognitive functions—in school-aged children preterm. Design, Setting, Participants This single-center cohort...
1 Extracardiac constraint and sensitivity to arterial pressure may be critical factors that limit the functional reserves of developing fetal heart in utero. We hypothesise extracardiac is predominant factor limits stroke volume (SV). To test this hypothesis we studied six chronically instrumented sheep determine relative roles play determining left ventricular (LV) function. 2 Pregnant ewes (128-131 days gestation, term = 147 days) were anaesthetised (5 mg kg−1 Propofol I.V., then 1.5 %...