A5009392053- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Regulation of Appetite and Obesity
- Pregnancy and preeclampsia studies
- Neonatal Respiratory Health Research
- Obesity, Physical Activity, Diet
- Epigenetics and DNA Methylation
- Breastfeeding Practices and Influences
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Neuroendocrine regulation and behavior
- Infant Nutrition and Health
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Neuropeptides and Animal Physiology
- Biochemical Analysis and Sensing Techniques
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diet, Metabolism, and Disease
- Assisted Reproductive Technology and Twin Pregnancy
- Infant Development and Preterm Care
- Child and Adolescent Health
- Sleep and Wakefulness Research
- Hypothalamic control of reproductive hormones
- Reproductive System and Pregnancy
- Congenital Diaphragmatic Hernia Studies
Charité - Universitätsmedizin Berlin
2015-2024
Humboldt-Universität zu Berlin
2002-2024
Freie Universität Berlin
2018-2024
Université Sorbonne Paris Nord
2020
Vivantes Klinikum
2020
Assistance Publique – Hôpitaux de Paris
2020
McMaster University
2016-2017
Center for Pediatric Endocrinology Zurich
2017
Heinrich Heine University Düsseldorf
2016-2017
Simon Fraser University
2016
Pre- and neonatal overfeeding programmes a permanent obesity disposition accompanying diabetic cardiovascular disorders, by unknown mechanisms. We proposed that early may alter DNA methylation patterns of hypothalamic promoter regions genes critically involved in the lifelong regulation food intake body weight. induced rearing Wistar rats small litters (SL) thereafter mapped status CpG dinucleotides gene promoters from tissue, using bisulfite sequencing. Neonatal led to rapid weight gain,...
To investigate possible permanent consequences of an early postnatal overfeeding, the following experimental model was used: Male Wistar rats were divided into three groups after birth: (1) Small litters with 3-4 newborns (overnutrition), (2) normal 12 animals (normonutrition), and (3) large 20-24 newborn (undernutrition). After weaning all had free access to tap water standard pellet diet. The serum insulin level from small on day 15 life highly significantly increased as compared other...
Offspring born to women with pregnancies complicated by diabetes are at increased childhood risk of developing obesity and impaired glucose tolerance (IGT). In population-based studies, breast-feeding has been shown be protective against later in life. To date, the role on offspring diabetic mothers (ODM) not investigated this context.A total 112 ODM (type 1 diabetes, n = 83; gestational 29) were evaluated prospectively for impact ingestion either breast milk (DBM) or nondiabetic banked...
OBJECTIVE—To investigate the growth of children from pregnancies with gestational diabetes mellitus (GDM) and its association antenatal maternal, fetal, recent anthropometric parameters mother father. RESEARCH DESIGN AND METHODS—In 324 Caucasian women GDM, BMI before pregnancy, maternal glycemic values, measurements fetal abdominal circumference were recorded. The weight height infants measured at birth follow-up 5.4 years (range 2.5–8.5). In addition, somatic data routine examinations 6,...
Background —Immunoadsorption (IA) and subsequent immunoglobulin (Ig) G substitution represent an additional therapeutic approach in dilated cardiomyopathy (DCM). It remains to be elucidated whether this treatment modulates myocardial inflammation, which is possibly a causal factor of ventricular dysfunction. Methods Results —From 25 DCM patients (EF <30%), 12 were randomized for IA therapy IgG at 1-month intervals until month 3. Before (<7 days) after therapy, right biopsies obtained...
Aim: Prenatal and neonatal overfeeding programs a permanent obesity diabetes disposition, e.g., due to induction of hypothalamic insulin resistance. We investigated acquired alterations the DNA methylation pattern receptor promoter (IRP) which might be an underlying molecular mechanism.
Maternal low protein malnutrition during gestation and lactation (LP) is an animal model frequently used for the investigation of long-term deleterious consequences perinatal growth retardation. Both retardation at birth are risk factors diabetic cardiovascular disturbances in later life. The pathophysiologic mechanisms responsible unknown. Hypothalamic nuclei decisively involved central nervous regulation food intake, body weight metabolism. We investigated effects a diet (8% protein;...
We recently reported on an elevation of neurons expressing the main orexigenic peptide neuropeptide Y (NPY) in arcuate hypothalamic nucleus (ARC) neonatally hyperinsulinaemic offspring gestational diabetic mother rats (GD) at weaning. To investigate possible consequences, long-term outcome those animals was examined. At adult age, GD showed hyperphagia (p < 0.001), basal hyperinsulinaemia 0.05) and impaired glucose tolerance 0.05), were overweight 0.01). This accompanied by elevated number...
Litter size is a biological variable that strongly influences adult physiology in rodents. Despite evidence from previous decades and recent studies highlighting its major impact on metabolism, information about litter currently underreported the scientific literature. Here, we urge this important should be explicitly stated research articles.
Insulin is a potent modulator of central nervous development and suggested to influence the differentiation maturation hypothalamic structures involved in regulation body weight metabolism. Hyperinsulinemic offspring mothers with impaired glucose tolerance during pregnancy (gestational diabetes, GD) have an increased risk develop overweight diabetes mellitus life, while underlying pathophysiological mechanisms are still unknown. To investigate effects perinatal hyperinsulinism on...
Food intake and energy expenditure are regulated by neuropeptides in the hypothalamus. While cocaine- amphetamine-regulated transcript (CART) peptide melanocortins such as alpha-melanocyte-stimulating hormone (alpha-MSH) anorexigenic increase expenditure, endogenous melanocortin receptor antagonist agouti gene-related protein (AGRP), melanin-concentrating (MCH) neuropeptide Y (NPY) orexigenic, anabolic peptides. Alterations regulatory balance may promote excessive weight gain. The action of...