A5060733104- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Biochemical Analysis and Sensing Techniques
- Hypothalamic control of reproductive hormones
- Birth, Development, and Health
- Pancreatic function and diabetes
- Diet and metabolism studies
- Neuropeptides and Animal Physiology
- Growth Hormone and Insulin-like Growth Factors
- Neuroendocrine regulation and behavior
- Sleep and Wakefulness Research
- Adipokines, Inflammation, and Metabolic Diseases
- Axon Guidance and Neuronal Signaling
- Autophagy in Disease and Therapy
- Receptor Mechanisms and Signaling
- Neuroscience of respiration and sleep
- Circadian rhythm and melatonin
- Neurogenesis and neuroplasticity mechanisms
- Barrier Structure and Function Studies
- Diet, Metabolism, and Disease
- Genetic Syndromes and Imprinting
- Eating Disorders and Behaviors
- Pregnancy and preeclampsia studies
- Obesity, Physical Activity, Diet
- Stress Responses and Cortisol
Inserm
2015-2025
Université de Lille
2016-2025
Centre Hospitalier Universitaire de Lille
2020-2025
Lille Neurosciences & Cognition
2018-2024
European Genomic Institute for Diabetes
2024
Centre de Recherche Jean Pierre Aubert
2013-2022
University of Southern California
2010-2019
Children's Hospital of Los Angeles
2010-2019
University of California, Los Angeles
2018
Southern California University for Professional Studies
2010-2018
In adult mammals, the adipocyte-derived hormone leptin acts on brain to reduce food intake by regulating activity of neurons in arcuate nucleus hypothalamus (ARH). Here, we report that neural projection pathways from ARH are permanently disrupted leptin-deficient (Lep ob /Lep ) mice and treatment adulthood does not reverse these neuroanatomical defects. However, Lep neonates with exogenous rescues development projections, promotes neurite outgrowth vitro. These results suggest plays a...
The arcuate nucleus of the hypothalamus (ARH) is a critical component forebrain pathways that regulate variety neuroendocrine functions, including an important role in relaying leptin signals to other parts hypothalamus. However, neonatal rodents do not lose weight response treatment same way as adults, suggesting certain aspects signaling may be mature. We tested this possibility by using DiI axonal labeling examine development projections from ARH mice, paying particular attention...
The median eminence is one of the seven so-called circumventricular organs. It located in basal hypothalamus, ventral to third ventricle and adjacent arcuate nucleus. This structure characteristically contains a rich capillary plexus features fenestrated endothelium, making it direct target blood-borne molecules. also highly specialized ependymal cells called tanycytes, which line floor ventricle. has been hypothesized that functions these create barrier prevents substances portal spaces...
ABSTRACT Tanycytes are highly specialized ependymal cells that form a blood–cerebrospinal fluid (CSF) barrier at the level of median eminence (ME), circumventricular organ (CVO) located in tuberal region hypothalamus. This layer harbors well‐organized tight junctions, hallmark central nervous system barriers is lacking fenestrated portal vessels ME. The displacement properties from vascular to ventricular side allows diffusion blood‐borne molecules into parenchyma ME while tanycyte junctions...
Circulating hormones influence multiple aspects of hypothalamic development and play a role in directing formation neural circuits. Leptin is secreted by adipocytes functions as key developmental signal that promotes axon outgrowth from the arcuate nucleus (ARH) during discrete critical period. To determine cellular mechanisms which leptin impacts circuits, we examined roles for receptor (LepRb) signals neonatal mice. LepRb, ERK, STAT3 signaling were required leptin-stimulated neurite ARH...
Abstract Leptin plays a pivotal role in the regulation of energy homeostasis and neuroendocrine functions, increasing evidence indicates that leptin acts on brain to mediate many these effects. Recent data have also suggested influences development during early postnatal life. Here we examined distribution cells express mRNA encoding long form receptor ( LepRb ) adult mouse brains by using situ hybridization. In both adults neonates, was largely restricted regions known control balance....
A complex neural network regulates body weight and energy balance, dysfunction in the communication between gut this is associated with metabolic diseases, such as obesity. The stomach-derived hormone ghrelin stimulates appetite through interactions neurons arcuate nucleus of hypothalamus (ARH). Here, we evaluated physiological neurobiological contribution during development by specifically blocking action early postnatal mice. Ghrelin blockade neonatal mice resulted enhanced ARH projections...
Excess nutrient supply and rapid weight gain during early life are risk factors for the development of obesity adulthood. This metabolic malprogramming may be mediated by endocrine disturbances critical periods development. Ghrelin is a hormone secreted from stomach that acts centrally to promote feeding behavior binding growth secretagogue receptors in arcuate nucleus hypothalamus. Here, we examined whether neonatal overnutrition causes changes ghrelin system. We used well-described mouse...
Maternal diabetes is a common complication of pregnancy, and the offspring diabetic mothers have higher risk developing obesity type 2 later in life. Despite these observations, precise biological processes mediating this metabolic programming are not well understood. Here, we explored consequences maternal on organization hypothalamic neural circuits involved regulation energy balance. To accomplish aim, used mouse model insulin deficiency induced by streptozotocin injections. was found to...
The transition to puberty and adult fertility both require a minimum level of energy availability. adipocyte-derived hormone leptin signals the long-term status peripheral stores serves as key metabolic messenger neuroendocrine reproductive axis. Humans mice lacking or its receptor fail complete are infertile. Restoration levels in these individuals promotes sexual maturation, which requires pulsatile, coordinated delivery gonadotropin-releasing pituitary resulting surge luteinizing (LH);...
Hypothalamic melanocortin neurons play a pivotal role in weight regulation. Here, we examined the contribution of Semaphorin 3 (SEMA3) signaling to development these circuits. In genetic studies, found 40 rare variants SEMA3A-G and their receptors (PLXNA1-4; NRP1-2) 573 severely obese individuals; disrupted secretion and/or through multiple molecular mechanisms. Rare this set genes were significantly enriched 982 cases compared 4,449 controls. zebrafish mutagenesis screen, deletion 7 pathway...