A5083531243- Lipid Membrane Structure and Behavior
- Heat shock proteins research
- Endoplasmic Reticulum Stress and Disease
- Lipid metabolism and biosynthesis
- Metabolomics and Mass Spectrometry Studies
- Protein Structure and Dynamics
- Adipose Tissue and Metabolism
- Microbial Metabolic Engineering and Bioproduction
- Fatty Acid Research and Health
- Receptor Mechanisms and Signaling
- Cholesterol and Lipid Metabolism
- Mitochondrial Function and Pathology
- thermodynamics and calorimetric analyses
- Cellular transport and secretion
- Cancer, Lipids, and Metabolism
- RNA and protein synthesis mechanisms
- Peroxisome Proliferator-Activated Receptors
- Eicosanoids and Hypertension Pharmacology
- Erythrocyte Function and Pathophysiology
- Diet and metabolism studies
- Autophagy in Disease and Therapy
- Granular flow and fluidized beds
- Ion channel regulation and function
- Photosynthetic Processes and Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
HUN-REN Szegedi Biológiai Kutatóközpont
2016-2025
Institute of Biochemistry
2016-2025
Hungarian Academy of Sciences
2011-2024
Hungarian Research Network
2021-2023
Ecole d'Ingénieurs de PURPAN
2014
Alzheimer disease is characterized by accumulation of the β-amyloid peptide (Aβ) generated β- and γ-secretase processing amyloid precursor protein (APP). The intake polyunsaturated fatty acid docosahexaenoic (DHA) has been associated with decreased deposition a reduced risk in several epidemiological trials; however, exact underlying molecular mechanism remains to be elucidated. Here, we systematically investigate effect DHA on amyloidogenic nonamyloidogenic APP potential cross-links...
Understanding how plants sense and respond to heat stress is central improve crop tolerance productivity. Recent findings in Physcomitrella patensdemonstrated that the controlled passage of calcium ions across plasma membrane regulates shock response (HSR). To investigate effect lipid composition on plant HSR, we acclimated P. patens a slightly elevated yet physiological growth temperature analysed signature influx under mild shock. Compared tissues grown at 22°C, 32°C had significantly...
Aging and pathophysiological conditions are linked to membrane changes which modulate membrane-controlled molecular switches, causing dysregulated heat shock protein (HSP) expression. HSP co-inducer hydroxylamines such as BGP-15 provide advanced therapeutic candidates for many diseases since they preferentially affect stressed cells unlikely have major side effects. In the present study in vitro dynamic simulation, experiments with lipid monolayers vivo ultrasensitive fluorescence microscopy...
Apolipoprotein E4 (apoE4) is the most prevalent genetic risk factor for Alzheimer's disease (AD). Epidemiological studies revealed that consumption of docosahexaenoic acid (DHA: 22 : 6 (ω3)), a major brain polyunsaturated fatty acid, protective fo
Cellular membranes respond rapidly to various environmental perturbations. Previously we showed that modulations in membrane fluidity achieved by heat stress (HS) resulted pronounced organization alterations which could be intimately linked the expression and cellular distribution of shock proteins. Here examine heat-induced changes using several visualisation methods. With Laurdan two-photon microscopy demonstrate that, contrast enhanced formation ordered domains surface membranes,...
MEPS Marine Ecology Progress Series Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsTheme Sections 512:39-54 (2014) - DOI: https://doi.org/10.3354/meps10864 Temporal and inter-specific variations in forage fish feeding conditions NW Mediterranean: lipid content fatty acid compositional changes H. Pethybridge1, N. Bodin2,3,*, E.-J. Arsenault-Pernet3, J.-H. Bourdeix4, B. Brisset4, J.-L. Bigot4, D. Roos4, M....
Membrane function is fundamental to life. Each species explores membrane lipid diversity within a genetically predefined range of possibilities. How composition in turn defines the functional space available for evolution membrane-centered processes remains largely unknown. We address this question using related fission yeasts Schizosaccharomyces pombe and japonicus. show that, unlike S. that generates membranes where both glycerophospholipid acyl tails are predominantly 16–18 carbons long,...
Changes in the levels of three structurally and functionally different important thermoprotectant molecules, namely small heat shock proteins (sHsps), trehalose, lipids, have been investigated upon Schizosaccharomyces pombe. Both α-crystallin-type sHsps (Hsp15.8 Hsp16) were induced after prolonged high-temperature treatment but with kinetic profiles. The shsp null mutants display a weak, significant, sensitivity indicating their importance thermal stress management. induction is wild type...
Prediabetes is a condition affecting more than 35% of the population. In some forms, excessive carbohydrate intake (primarily refined sugar) plays prominent role. symptomless, mostly unrecognized disease which increases cardiovascular risk. our work, we examined effect fructose-enriched diet on cardiac function and lipidome as well proteome muscle. Male Wistar rats were divided into two groups. The control group received normal while fructose-fed 60% fructose-supplemented chow for 24 weeks....
Cell membranes actively participate in stress sensing and signalling. Here we present the first in-depth lipidomic analysis to characterize alterations fission yeast Schizosaccharomyces pombe response mild heat (HS). The lipidome was assessed by a simple one-step methanolic extraction. Genetic manipulations that altered triglyceride (TG) content absence or presence of HS gave rise distinct fingerprints for S. pombe. Cells unable produce TG demonstrated long-lasting growth arrest enhanced...
Drosophila spermatogenesis is an ideal system to study the effects of changes in lipid composition, because spermatid elongation and individualization requires extensive membrane biosynthesis remodelling. The bulk transcriptional activity completed with entry cysts into meiotic division, which makes post-meiotic stages very sensitive even a small reduction gene products. In this study, we describe effect composition during using hypomorphic male sterile allele CDP-DAG synthase ( CdsA ) gene....
Inappropriate nutrition and a sedentary lifestyle can lead to obesity, one of the most common risk factors for several chronic diseases. Although regular physical exercise is an efficient approach improve cardiometabolic health, exact cellular processes are still not fully understood. We aimed analyze morphological, gene expression, lipidomic patterns in liver adipose tissues response exercise. Healthy (wild type on normal diet) hyperlipidemic, high-fat diet-fed (HFD-fed) apolipoprotein...
Abstract Background Obesity is a growing problem worldwide and major risk factor for many chronic diseases. The accumulation of adipose tissue leads to the release significant amounts pro-inflammatory cytokines adipokines, resulting in low-grade systemic inflammation. However, mechanisms behind development obesity-related diseases are not fully understood. Therefore, our study aimed investigate pathological changes inflammatory processes at level individual organs two different diet-induced...
Biosynthesis of lipids and fatty acids (FAs) is a tightly regulated complex process essential for the normal functioning various cellular processes as sufficient lipid availability progression several malignant tumor types. Despite its importance, roles individual steps in biosynthesis during growth their subsequent interaction with intracellular signaling pathways are still not well understood. In our study, we used RasV12, Scribble deficient carcinoma model Drosophila to demonstrate that...
Background and objectives: Post-operative pain (POP) is a common complication after root canal treatment influenced by various clinical patient-related factors. The present study evaluated the incidence intensity of POP following using bioceramic sealer, performed operators with different levels experience. Material methods: A total 115 patients were included in this prospective observational study. Patients treated experience: postgraduate students (PGSs) endodontic specialists (ESs)....
Multiple sclerosis (MS) and Guillain-Barré syndrome (GBS) are demyelinating disorders affecting the central nervous system peripheral (PNS), respectively. Cerebrospinal fluid (CSF) is one of most valuable sources diagnostic biomarkers in neurological diseases. In present study high sensitivity shotgun mass spectrometry was used to characterise CSF lipidome patients with MS, GBS controls non-demyelinating The quantification 222 lipid molecular species revealed characteristic changes absolute...
Homeostatic maintenance of the physicochemical properties cellular membranes is essential for life. In yeast, trehalose accumulation and lipid remodeling enable rapid adaptation to perturbations, but their crosstalk was not investigated. Here we report about first in-depth, mass spectrometry-based lipidomic analysis on heat-stressed Schizosaccharomyces pombe mutants which are unable synthesize (tps1Δ) or degrade (ntp1Δ) trehalose. Our experiments provide data role as a membrane protectant in...