A5029548943- Autopsy Techniques and Outcomes
- Prenatal Screening and Diagnostics
- Birth, Development, and Health
- Neonatal Respiratory Health Research
- Dementia and Cognitive Impairment Research
- Tumors and Oncological Cases
- Restraint-Related Deaths
- Neuroscience of respiration and sleep
- Connective tissue disorders research
- Urological Disorders and Treatments
- Genetic Syndromes and Imprinting
- Pregnancy and preeclampsia studies
- Congenital Diaphragmatic Hernia Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Ethics and Legal Issues in Pediatric Healthcare
- Renal and related cancers
- Congenital Anomalies and Fetal Surgery
- Neurofibromatosis and Schwannoma Cases
- Teratomas and Epidermoid Cysts
- Neuroblastoma Research and Treatments
- Fetal and Pediatric Neurological Disorders
- Autoimmune Bullous Skin Diseases
- Genetic and Kidney Cyst Diseases
- Bone and Dental Protein Studies
- Hepatocellular Carcinoma Treatment and Prognosis
Women's and Children's Hospital
2015-2024
The University of Adelaide
2012-2024
South Australia Pathology
2012-2024
University of Virginia Children's Hospital
2023
Boston Children's Hospital
1991-2013
Dementia Australia
2008-2012
Manchester Royal Infirmary
1998
St. Mary’s Hospital
1997
St. Mary's Hospital
1995-1997
University of Toronto
1996
Hepatocellular carcinoma (HCC) is rare in young children. We attempted to see if immunohistochemical and mutational-analysis studies could demonstrate that deficiency of the canalicular bile acid transporter salt export pump (BSEP) mutation ABCB11 , encoding BSEP, underlay progressive familial intrahepatic cholestasis (PFIC)—or “neonatal hepatitis” suggesting PFIC—that was associated with HCC studied 11 cases pediatric setting PFIC or PFIC. Archival liver were retrieved immunostained for...
Nephrogenesis is ongoing at the time of birth for majority preterm infants, but whether postnatal renal development follows a similar trajectory to normal in utero growth unknown. Here, we examined tissue collected autopsy from 28 kidneys neonates, whose survival ranged 2 68 days, including 6 that had restricted intrauterine growth. In addition, 32 still-born gestational controls. We assessed width nephrogenic zone, number glomerular generations, cross-sectional area corpuscle, and maturity...
<i>Background:</i> Computerized cognitive testing has the potential to be an effective way assess and monitor cognition in large neuroepidemiological studies. CogState is a game-like computerized test with demonstrated validity reliability that shown sensitivity decline older individuals over time. This study aimed evaluate serial usability of specifically within community cohort. <i>Methods:</i> The battery was administered healthy volunteers aged 50 years above at...
Worldwide, approximately 10% of neonates are born preterm. The majority preterm when the kidneys still developing; therefore, during early postnatal period renal function is likely reflective immaturity and/or injury. This study evaluated glomerular and tubular urinary neutrophil gelatinase-associated lipocalin (NGAL; a marker injury) in first month life. Preterm term infants were recruited from Monash Newborn (neonatal intensive care unit at Medical Centre) Jesse McPherson Private Hospital,...
BackgroundDuring normal human kidney development, nephrogenesis (the formation of nephrons) is complete by term birth, with the majority nephrons formed late in gestation. The aim this study was to morphologically examine fetal kidneys from 20 41 weeks gestation.MethodsKidney samples were obtained at autopsy 71 infants that died acutely utero or within 24 h after birth. Using image analysis, nephrogenic zone width, number glomerular generations, renal corpuscle cross-sectional area and...
Abstract Background Progressive intraindividual decline in memory and cognition is characteristic of dementia may be useful detecting very early Alzheimer's disease pathology. Methods This study evaluated the slopes cognitive performance over a 12‐month period 263 healthy, community‐dwelling, adult volunteers aged ≥50 years. Participants completed brief computerized battery tests (CogState) at baseline during 3‐, 6‐, 9‐, follow‐up assessments. Linear mixed models were used to estimate...
Recommended treatment for travelers' diarrhea includes the combination of an antibiotic, usually a fluoroquinolone or azithromycin, and loperamide rapid resolution symptoms. However, adverse events, postdose nausea with high-dose effectiveness single-dose rifaximin, emerging resistance to front-line agents are evidence gaps underlying current recommendations.A randomized, double-blind trial was conducted in 4 countries (Afghanistan, Djibouti, Kenya, Honduras) between September 2012 July...
Central conducting lymphatic anomaly (CCLA), characterized by the dysfunction of core collecting vessels including thoracic duct and cisterna chyli, presenting as chylothorax, pleural effusions, chylous ascites, lymphedema, is a severe disorder often resulting in fetal or perinatal demise. Although pathogenic variants RAS/mitogen activated protein kinase (MAPK) signaling pathway components have been documented some patients with CCLA, genetic etiology remains uncharacterized most cases....
Acute upper airway obstruction in a 4-month-old male infant who presented as sudden death syndrome is described. At autopsy external tracheal compression and tracheobronchitis with plugging of the trachea bronchi by an abundant mucopurulent exudate were found. The source inflammation was adjacent esophagus where previous impaction coin had caused pressure necrosis mucosal erosion transmural granulation tissue formation. This case reported to demonstrate that foreign bodies remain esophagus,...
A nine-year-old boy died suddenly and unexpectedly following a two day history of intermittent headaches. At autopsy colloid cyst the third ventricle was found that had obstructed foramen Monro caused hydrocephalus with prominent cerebral edema. Colloid cysts are rare entities in childhood not usually included differential diagnosis pediatric sudden death. This report describes clinicopathological features such case.
SUMMARY A 3½‐year‐old boy presented on three occasions with painful, itchy, oedematous plaques his limbs. On two he had received hepatitis B vaccination 11–13 days previously, and the third occasion triple antigen (DTP) 10 earlier. Skin biopsy revealed a prominent infiltrate of eosinophils involving entire thickness dermis. In addition there were ‘flame figures’ consisting eosinophilic necrotic collagen surrounded by granular basophilic debris. The clinical histological pictures consistent...
This study was undertaken to investigate the occurrence of viral infection in fetal death by examining tissues for presence DNA several agents. Tissue specimens including heart, kidney, liver, lung, and placenta 73 cases were examined with 27 elective termination pregnancy as a control group. extracted from these samples tested HSV, CMV, EBV, VZV, HHV-6, HHV-7, PVB19. Viral found one or more tissue 25/73 (34%): CMV 20, HSV 5, parvovirus B19 HHV-7 3, HHV-6 2. The has been reported rarely. No...
Dentigerous cysts are usually of developmental nature but may be inflammatory origin especially in paediatric populations. It is important to understand the histological features dentigerous enable accurate diagnosis. The aim this study present epidemiological, clinical and histopathological seen a tertiary referral hospital.The medical, radiographic histopathology records Department Pathology, Women's Children's Hospital, Adelaide, Australia, during January 1998 December 2013 were reviewed...
ABSTRACT It has been proposed that sudden and unexpected death in infants due to intestinal infection with Clostridium botulinum may mimic the clinicopathological features of infant deathsyndrome. Between 3.3 3.8% some series have had this neurotoxin‐producing bacterium isolated on faecal culture. Prospective screening 248 presenting syndrome Adelaide Children's Hospital over a 10 year period from 1981to 1990 was conducted. Faecal samples were obtained both small large intestines cultured...
Records of the Adelaide Children's Hospital Histopathology Department were reviewed for cases deaths resulting from hanging or wedging occurring in early childhood and infancy. The 14 identified analyzed with respect to age, sex, circumstances death, postmortem findings. mean age at death was months (range, 6-36 months) male female ratio 9:5. In one case, occurred a baby car seat, another pram/stroller, curtain cord responsible. remaining 11 cases, baby's crib. eight mechanism partial...