A5000053818- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Lymphatic System and Diseases
- Immune cells in cancer
- Cytomegalovirus and herpesvirus research
- Vascular Malformations and Hemangiomas
- Autoimmune and Inflammatory Disorders Research
- HIV Research and Treatment
- Hippo pathway signaling and YAP/TAZ
- Renal and related cancers
- Immunotherapy and Immune Responses
- Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Cellular Mechanics and Interactions
- Optical Coatings and Gratings
- Neonatal Respiratory Health Research
- T-cell and Retrovirus Studies
- Microfluidic and Bio-sensing Technologies
- Legionella and Acanthamoeba research
- Lymphatic Disorders and Treatments
- Reproductive System and Pregnancy
- Bacterial biofilms and quorum sensing
- Mosquito-borne diseases and control
- Near-Field Optical Microscopy
- Antimicrobial Resistance in Staphylococcus
Centre for Cancer Biology
2020-2023
University of South Australia
2019-2023
South Australia Pathology
2020-2023
Lions Eye Institute
2018
The University of Western Australia
2018
University of Manchester
2013-2017
Centre for Inflammation Research
2013-2017
Imperial College London
2013
Jagiellonian University
2011
Key Points Rituximab causes a polarization of B cells, involving reorganization CD20, intercellular adhesion molecule 1, and moesin, orientation the microtubule organizing center. The cells induced by rituximab augments its therapeutic role in triggering ADCC effector NK cells.
Staphylococcus aureus possesses 16 two-component systems (TCSs), two of which (GraRS and NsaRS) belong to the intramembrane-sensing histidine kinase (IM-HK) family, is conserved within firmicutes. NsaRS has recently been documented as being important for nisin resistance in S. . In this study, we present a characterization reveal that, with other IM-HK TCSs, it responds disruptions cell envelope. Analysis using lacZ reporter–gene fusion demonstrated that nsaRS expression upregulated by...
The repositioning of inhibitory receptors on natural killer cells by an activating receptor is revealed superresolution microscopy.
Super-resolution microscopy has revealed that immune cell receptors are organized in nanoscale clusters at surfaces and synapses. However, mechanisms functions for this organization remain unclear. Here, we used super-resolution to compare the surface of paired killer Ig-like (KIR), KIR2DL1 KIR2DS1, on human primary natural cells lines. Activating KIR2DS1 assembled two-fold larger than its inhibitory counterpart KIR2DL1. Site-directed mutagenesis established size nanoclusters is controlled...
The atypical cadherin FAT4 has established roles in the regulation of planar cell polarity and Hippo pathway signaling that are context dependent. recent identification mutations Hennekam syndrome, features which include lymphedema, lymphangiectasia, mental retardation, uncovered an important role for lymphatic vasculature. syndrome is also caused by collagen calcium binding EGF domains 1 (CCBE1) ADAM metallopeptidase with thrombospondin type motif 3 (ADAMTS3), encoding a matrix protein...
Central conducting lymphatic anomaly (CCLA), characterized by the dysfunction of core collecting vessels including thoracic duct and cisterna chyli, presenting as chylothorax, pleural effusions, chylous ascites, lymphedema, is a severe disorder often resulting in fetal or perinatal demise. Although pathogenic variants RAS/mitogen activated protein kinase (MAPK) signaling pathway components have been documented some patients with CCLA, genetic etiology remains uncharacterized most cases....
Chediak-Higashi syndrome (CHS) is a rare disorder caused by biallelic mutations in the lysosomal trafficking regulator gene (LYST), resulting formation of giant lysosomes or lysosome-related organelles several cell types. The disease characterized immunodeficiency and fatal hemophagocytic lymphohistiocytosis impaired function cytotoxic lymphocytes, including natural killer (NK) cells.We sought to determine underlying biochemical cause cytotoxicity NK cells patients with CHS.We generated...
Recent outbreaks of Ebola and Zika have highlighted the possibility that viruses may cause enduring infections in tissues like eye, including neural retina, which been considered immune privileged. Whether this is a peculiarity exotic remains unclear, since impact more common viral on compartments has not examined, especially immunocompetent hosts. Cytomegalovirus common, universally distributed pathogen, generally innocuous healthy individuals. hosts cytomegalovirus can access reside there...
One potential strategy for the prevention of HIV infection is to induce virus specific mucosal antibody that can act as an immune barrier prevent transmission. The application chemokines after immunisation, termed "prime-pull", has been shown recruit T cells sites. We wished determine whether this could be used increase B and in vaginal mucosa following immunisation with antigen. BALB/c mice were immunised intranasally trimeric gp140 prior chemokine CCL28 or synthetic TLR4 ligand MPLA,...