Luis Arriola‐Martinez
A5033974585- Acute Myeloid Leukemia Research
- Lymphatic System and Diseases
- Hippo pathway signaling and YAP/TAZ
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Histiocytic Disorders and Treatments
- Vascular Tumors and Angiosarcomas
- Chronic Myeloid Leukemia Treatments
- Cancer-related molecular mechanisms research
- Chronic Lymphocytic Leukemia Research
- Hemoglobinopathies and Related Disorders
- Developmental Biology and Gene Regulation
- Renal and related cancers
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- RNA regulation and disease
- RNA Research and Splicing
- Neonatal Respiratory Health Research
- Wnt/β-catenin signaling in development and cancer
University of South Australia
2021-2024
Centre for Cancer Biology
2021-2024
South Australia Pathology
2021-2024
Garvan Institute of Medical Research
2017
Despite their abundance, the molecular functions of long non-coding RNAs in mammalian nervous systems remain poorly understood. Here we show that RNA, NEAT1, directly modulates neuronal excitability and is associated with pathological seizure states. Specifically, NEAT1 dynamically regulated by activity vitro vivo, binds epilepsy-associated potassium channel-interacting proteins including KCNAB2 KCNIP1, induces a hyper-potentiation phenotype iPSC-derived human cortical neurons following...
Individuals with germ line variants associated hereditary hematopoietic malignancies (HHMs) have a highly variable risk for leukemogenesis. Gaps in our understanding of premalignant states HHMs hampered efforts to design effective clinical surveillance programs, provide personalized preemptive treatments, and inform appropriate counseling patients. We used the largest known comparative international cohort germline RUNX1, GATA2, or DDX41 variant carriers without (HMs) identify patterns...
Abstract Despite a growing catalog of secreted factors critical for lymphatic network assembly, little is known about the mechanisms that modulate expression level these molecular cues in blood vascular endothelial cells (BECs). Here, we show BEC‐specific transcription factor, SOX7, plays crucial role non‐cell‐autonomous manner by modulating angiocrine signals to pattern vessels. While SOX7 not expressed (LECs), conditional loss function mouse embryos causes dysmorphic dermal phenotype. We...
Abstract The genomics era has facilitated the discovery of new genes that predispose individuals to bone marrow failure (BMF) and hematological malignancy (HM). We report ETS-related gene (ERG), a novel, autosomal dominant BMF/HM predisposition gene. ERG is highly constrained transcription factor critical for definitive hematopoiesis, stem cell function, platelet maintenance. colocalizes with other factors, including RUNX family 1 (RUNX1) GATA binding protein 2 (GATA2), on promoters or...
Abstract Despite a growing catalogue of secreted factors critical for lymphatic network assembly, little is known about the mechanisms that modulate expression level these molecular cues in blood vascular endothelial cells (BECs). Here, we show BEC-specific transcription factor, SOX7, plays crucial role vessel patterning by modulating lymphangiocrine signals. While SOX7 not expressed (LECs), loss function mouse embryos causes dysmorphic dermal phenotype. We identify novel distant regulatory...