A5063506763- Ion Channels and Receptors
- Helicobacter pylori-related gastroenterology studies
- Neuropeptides and Animal Physiology
- Essential Oils and Antimicrobial Activity
- Asthma and respiratory diseases
- Pharmacological Receptor Mechanisms and Effects
- Synthesis of β-Lactam Compounds
- Respiratory and Cough-Related Research
- Neurogenesis and neuroplasticity mechanisms
- Tryptophan and brain disorders
- Gastroesophageal reflux and treatments
- Neuroendocrine Tumor Research Advances
- Neuroscience of respiration and sleep
- Cannabis and Cannabinoid Research
- Gastrointestinal motility and disorders
- Respiratory Support and Mechanisms
- Lung Cancer Research Studies
- Stress Responses and Cortisol
- Indoor Air Quality and Microbial Exposure
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Phenothiazines and Benzothiazines Synthesis and Activities
- Odor and Emission Control Technologies
- Inhalation and Respiratory Drug Delivery
- Ion Transport and Channel Regulation
- Microbial metabolism and enzyme function
University of Pecs
2016-2024
Sex differences exist in chronic pain pathologies, and gonadal estradiol (E2) alters the sensation. The nocisensor transient receptor potential vanilloid 1 (TRPV1) plays a critical role triggering pain. Here we examined impact of E2 on function TRPV1 mice sensory neurons vitro vivo. Both mechano- thermonociceptive thresholds plantar surface paw female were significantly lower proestrus compared with estrus phase. These higher ovariectomized (OVX) sham-operated This difference was absent...
Smoking is recognised as an independent risk factor in the development of chronic pancreatitis (CP). Cystic fibrosis transmembrane conductance regulator (CFTR) function and ductal fluid bicarbonate secretion are also known to be impaired CP, so it crucial understand relationships between smoking, pancreatic CP.
Sporadic clinical reports suggested that marijuana smoking induces spontaneous pneumothorax, but no animal models were available to validate these observations and study the underlying mechanisms. Therefore, we performed a systematic in CD1 mice as predictive model assessed pathophysiological alterations response 4-mo-long whole body smoke with integrative methodologies comparison tobacco smoke. Bronchial responsiveness was measured unrestrained plethysmography, cell profile bronchoalveolar...
Introduction: The world population is ageing, resulting in increased prevalence of age-related comorbidities and healthcare costs. Limited data are available on intestinal health elderly populations. Structural functional changes, including altered visceroperception, may lead to bowel habits abdominal symptoms healthy individuals irritable syndrome (IBS) patients. Our aim was explore changes gastrointestinal underlying mechanisms. Methods: In total, 780 subjects (IBS patients n = 463, 317)...
Marijuana is a widely used recreational drug with increasing legalization worldwide for medical purposes. Most experimental studies use either synthetic or plant-derived cannabinoids to investigate the effect of on anxiety and cognitive functions. The aim this study was mimic real life situations where young people smoke cannabis regularly relax from everyday stress. Therefore, we exposed adult male NMRI mice daily stress concomitant marijuana 2 months investigated consequences physiology,...
Thyme (TO), cinnamon (CO), and Ceylon type lemongrass (LO) essential oils (EOs) are commonly used for inhalation. However, their effects mechanisms on inflammatory processes not well-documented, the number of in vivo data that would be important to determine potential benefits or risks is low. Therefore, we analyzed chemical composition investigated activity TO, CO, LO airway functions parameters an acute pneumonitis mouse model. The components commercially available EOs were measured by gas...
The Transient Receptor Potential Ankyrin 1 (TRPA1) cation channel expressed on capsaicin-sensitive afferents, immune and endothelial cells is activated by inflammatory mediators exogenous irritants, e.g., endotoxins, nicotine, crotonaldehyde acrolein. We investigated its involvement in acute chronic pulmonary inflammation using Trpa1 gene-deleted (Trpa1−/−) mice. Acute pneumonitis was evoked intranasal Escherichia coli endotoxin (lipopolysaccharide: LPS) administration, bronchitis daily...
Diabetes mellitus is a common metabolic disease leading to hyperglycemia due insufficient pancreatic insulin production or effect. Amine oxidase copper containing 3 (AOC3) an enzyme that belongs the semicarbazide-sensitive amine family, which may be novel therapeutic target treat diabetic complications. We aimed explore effects of AOC3 inhibition and test actions our inhibitor multi-target drug candidate, SZV 1287, compared selective reference compound, LJP 1207, in 8-week long...
Acute gastritis is often untreatable by acid secretion-inhibiting drugs. Understanding the protective mechanisms including role of Transient Receptor Potential Ankyrin1 (TRPA1) and Vanilloid1 (TRPV1) channels localized on capsaicin-sensitive afferents non-neuronal structures might identify novel therapeutic approaches. Therefore, we characterized a translational model using iodoacetamide (IAA) investigated TRPA1/V1 expressions. Wistar rats CD1, C57Bl/6J mice were exposed to IAA-containing...
<b>Introduction and aims:</b> Idiopathic pulmonary fibrosis is associated with a median survival of just 2-3 years after diagnosis. Current therapies ameliorate functional decrement, but do not inhibit the progression or reduce mortality. Thus, effective anti-fibrotic are desperately needed. Based on our previous results in other organs, we aimed to investigate whether Sigma-1 receptor (S1R) agonist fluvoxamine (FLU) can fibrosis. <b>Methods:</b> Fibrotic processes were induced TGF-β PDGF...
The potential role of the transient receptor Vanilloid 1 (TRPV1) non-selective cation channel in gastric carcinogenesis remains unclear. main objective this study was to evaluate TRPV1 expression cancer (GC) and precursor lesions compared with controls. Patient inclusion based on a retrospective review pathology records. Patients were subdivided into five groups: Helicobacter pylori (H. pylori)-associated gastritis intestinal metaplasia (GIM) (n = 12), chronic atrophic (CAG) GIM 13), H....
Several clinical studies indicate that smoking predisposes its consumers to esophageal inflammatory and malignant diseases, but the cellular mechanism is not clear. Ion transporters protect epithelial cells by maintaining intracellular pH at normal levels. In this study, we hypothesized affects function of ion transporters, thus playing a role in development smoking-induced diseases. Esophageal cell lines were treated with cigarettesmoke extract (CSE), viability proliferation cells, as well...
Force provided by elastomers used in orthodontics can be affected several factors present the oral cavity. The aim of our study was to investigate role mouthwashes, toothbrushing, and smoking force decay such elastomers. Tensile strength, changes continuously exerted, elastic chains (Ortho Organizer Masel Short Power Chain) ligatures (Dentaurum Masel) two separate manufacturers were measured. Measurements initially made on untreated elastics, followed exposure different environmental...
Abstract Background Cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) are often associated with airway fluid acidification. Mutations in the cystic transmembrane conductance regulator ( CFTR ) gene leads to impaired bicarbonate secretion contributing CF pathology. Chronic cigarette smoke (CS) -the major cause of COPD- is reported induce acquired dysfunction underlying acidification inflammation. We hypothesize that bicarbonate-containing aerosols could be beneficial for...
Scots pine (SO) and clove (CO) essential oils (EOs) are commonly used by inhalation, their main components shown to reduce inflammatory mediator production. The aim of our research was investigate the chemical composition commercially available SO CO gas chromatography-mass spectrometry study effects on airway functions inflammation in an acute pneumonitis mouse model. Inflammation evoked intratracheal endotoxin EOs were inhaled three times during 24 h experimental period. Respiratory...
Background: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease hallmarked by irreversible damage of cartilage and bone. Matrix metalloproteinases (MMPs) involved in connective tissue remodeling play an important role this process. Numerous MMPs have been examined humans animals, but their functions are still not fully understood. Therefore, we investigated the K/BxN serum-transfer model rheumatoid with broad-spectrum MMP inhibitor subantimicrobial dose doxycycline (SDD) using...