A5078938730- Gastroesophageal reflux and treatments
- Gastrointestinal motility and disorders
- Eosinophilic Esophagitis
- Esophageal and GI Pathology
- Helicobacter pylori-related gastroenterology studies
- Dysphagia Assessment and Management
- Esophageal Cancer Research and Treatment
- Diet and metabolism studies
- Music Therapy and Health
- Congenital gastrointestinal and neural anomalies
- Pathogenesis and Treatment of Hiccups
- Bariatric Surgery and Outcomes
- Tracheal and airway disorders
- Mental Health Research Topics
- Ion Channels and Receptors
- Gastric Cancer Management and Outcomes
- Health, psychology, and well-being
- Gut microbiota and health
- Respiratory and Cough-Related Research
- Whipple's Disease and Interleukins
- Child Nutrition and Feeding Issues
- Complementary and Alternative Medicine Studies
- Gastrointestinal disorders and treatments
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Therapeutic Uses of Natural Elements
Maastricht University Medical Centre
2008-2025
Maastricht University
2013-2024
University Medical Center
2007-2019
Erasmus MC
2010
University Medical Center Utrecht
2005-2007
Utrecht University
2005-2007
University of Groningen
2007
Objectives: Transoral incisionless fundoplication (TIF) was developed in an attempt to create a minimally invasive endoscopic procedure that mimics antireflux surgery. The objective of this trial evaluate effectiveness TIF compared with proton pump inhibition population consisting gastroesophageal reflux disease (GERD) patients controlled inhibitors (PPIs) who opted for intervention over lifelong drug dependence. Methods: Patients chronic GERD were randomized (2:1) or continuation PPI...
Intestinal permeability has been studied in small groups of IBS patients with contrasting findings.To assess intestinal at different sites the GI tract subtypes well-characterised and healthy controls (HC), to potential confounding factors.IBS HC underwent a multi-sugar test site-specific permeability. Sucrose excretion lactulose/rhamnose ratio 0-5 h urine indicated gastroduodenal permeability, respectively. Sucralose/erythritol 0-24 5-24 whole gut colonic Linear regression analysis was used...
BACKGROUND The additional yield of esophageal impedance monitoring in identification reflux as the cause symptoms is unknown. OBJECTIVES To compare symptom–reflux association analysis combined pH-impedance data with pH alone. METHODS In 60 patients heartburn and regurgitation combined, 24-h was performed. Acid-suppressive medication stopped 1 wk advance. Patients (48) at least one symptom during measurement period were selected for further analysis. instructed to note time nature their...
<b>Background:</b> Endoscopic treatment for gastro-oesophageal reflux disease (GORD) is rapidly emerging, but there a great need randomised controlled trials to evaluate the efficacy. <b>Design and setting:</b> A single-centre, double-blind, randomised, sham-controlled trial of endoscopic gastroplication by Endocinch suturing system. <b>Patients interventions:</b> 60 patients with GORD were randomly assigned three gastroplications (n = 20), sham procedure 20) or observation 20). The research...
Abstract Background Visceral hypersensitivity is a frequently observed hallmark of irritable bowel syndrome (IBS). Studies have reported differently about the presence visceral in IBS resulting from lack standardization barostat procedure and due to different criteria used assess hypersensitivity. We aimed calculate optimal cutoff detect IBS. Methods A total 126 patients 30 healthy controls (HC) were included for assessment visceroperception by barostat. Pain perception was assessed on...
Alterations in serotonin (5-HT) metabolism have been postulated to play a role the pathogenesis of irritable bowel syndrome (IBS). However, previous reports regarding 5-HT IBS are contradicting.To compare platelet poor plasma (PPP) and 5-hydroxyindole acetic acid (5-HIAA) levels their ratio large cohort patients healthy controls (HC), including IBS-subgroup analysis.Irritable HC were evaluated for fasting PPP 5-HIAA levels. Furthermore, GI-symptom diary, GSRS, quality life, anxiety...
Non-obstructive dysphagia (NOD) often poses diagnostic problems. The aim of this study was to evaluate the value addition multichannel intraluminal impedance (MII) recording esophageal manometry in work-up patients with NOD.A total 40 consecutive NOD underwent combined MII and perfusion manometry. Ten liquid 10 viscous boluses were tested each patient. Values for bolus presence time (BPT) at four sites transit (TBTT) calculated. Bolus (BT) considered be normal when BPT all TBTT within limits...
<h3>Background</h3> Pneumatic balloon dilatation (PD) is a regular treatment modality for achalasia. The reported success rates of PD vary. Recurrent symptoms often require repeated or surgery. <h3>Objective</h3> To identify predicting factors symptom recurrence requiring treatment. <h3>Methods</h3> Between 1974 and 2006, 336 patients were treated with included in this longitudinal cohort study. median follow-up was 129 months (range 1–378). Recurrence achalasia defined as combination...
Irritable bowel syndrome (IBS) is a heterogenous disorder with visceral hypersensitivity as important hallmark. It not known whether IBS patients have different epidemiological and clinical characteristics compared without hypersensitivity. Aim of our study was to compare in detail large group hyper- vs normosensitive respect characteristics.IBS (Rome III criteria) been recruited for large-scale cohort study. All from this who underwent rectal barostat procedure were included allocated based...
Achalasia is characterized by a functional esophagogastric junction (EGJ) obstruction. The luminal imaging probe (EndoFLIP) method to assess EGJ distensibility. In homogeneous group of newly diagnosed achalasia patients treated with pneumatic dilation (PD), we aimed (i) determine whether the assessment distensibility has added value in management and (ii) evaluate differs between subtypes.Twenty-six were graded PD (30 35 mm) separated 1 week. was measured EndoFLIP technique before after 30...
Transoral incisionless fundoplication is a recently introduced endoluminal technique for the treatment of gastroesophageal reflux disease (GERD). The objective this study was to determine outcomes in chronic GERD patients who were referred surgical management.A cohort 38 underwent transoral (TIF) tertiary care setting. Pre- and post-procedure assessment included GERD-related quality life questionnaires, proton pump inhibitor (PPI) usage, 24-h pH measurements, upper gastrointestinal...
Abstract Background Irritable bowel syndrome ( IBS ) is characterized by heterogeneous pathophysiology and low response to treatment. Up 60% of patients suffers from visceral hypersensitivity, which associated with symptom severity underlying pathophysiological mechanisms. Recently, positive effects probiotics in have been reported, but overall the was modest. We performed a study patients, hypersensitivity measured rectal barostat, aiming assess effect 6 weeks multispecies probiotic mix on...
Summary Background A previous single‐centre study showed that lower oesophageal sphincter electrical stimulation therapy (LES‐EST) in gastro‐oesophageal reflux disease (GERD) patients improves symptoms and decreases acid exposure. Aim To evaluate safety efficacy of LES‐EST GERD with incomplete response to proton pump inhibitors (PPIs) a prospective, international, multicentre, open‐label study. Methods patients, partially responsive PPIs, received LES‐EST. health‐related quality life...
Abstract Background Antireflux therapy may lead to recovery of impaired mucosal integrity in gastro‐esophageal reflux disease ( GERD ) patients as reflected by an increase baseline impedance. The study objective was evaluate the effect endoscopic fundoplication and proton pump inhibitor PPI on impedance heartburn severity patients. Methods Forty‐seven randomized n = 32) or 15), 29 healthy controls were included. Before randomization 6 months after treatment, obtained during 24‐h pH‐impedance...
Abstract Background and study aims There are no reliable data to predict which patients with gastroparesis (GP) would benefit the most from gastric peroral endoscopic pyloromyotomy (G-POEM). The aim of present was assess whether antro-duodenal motility patterns pyloric distensibility can outcome G-POEM in decompensated GP. Patients methods In an open-label study, GP refractory symptoms were eligible for treatment if attempts according a standardized stepwise protocol had failed. Baseline...
ABSTRACT Hypermobility spectrum disorders (HSD) and hypermobility Ehlers–Danlos syndrome (hEDS) are frequently associated with gastrointestinal symptoms, although the underlying mechanisms remain unclear. This study aimed to compare antroduodenal motility in patients without HSD/hEDS. We included 239 (50 HSD/hEDS 189 non‐HSD/hEDS) symptoms undergoing manometry (ADM). The prevalence of dysmotility was not different between both groups, but enteric less common group (13% vs. 34%, p = 0.006)....
Rumination syndrome is a disorder of unknown etiology characterized by regurgitation recently ingested food. We aimed to improve the diagnosis rumination classification separate symptoms using (1) an ambulatory manometry/impedance (AMIM) measurement and (2) single-catheter high-resolution (HRIM) measurement.A total 96 during AMIM 37 HRIM were analyzed in five patients with clinically diagnosed syndrome.AMIM identified events 85 out reported (symptom index (SI): 89%). Of these events, 63%...
Objective There is no evidence-based treatment for persistent dysphagia after laparoscopic fundoplication. The aim of this study was to evaluate the effect pneumatic dilation on Design We performed a multicentre, single-blind, randomised sham-controlled trial patients with (>3 months) Patients an Eckardt symptom score ≥4 were randomly assigned (PD) using 35 mm balloon or sham dilation. Primary outcome success, defined as <4 and minimal reduction 2 points in 30 days. Secondary outcomes...
Abstract Multichannel intraluminal impedance (MII) is being used increasingly to assess oesophageal bolus clearance. However, there no good standardization of the parameters that define ‘effective clearance’. The aim this study was these important and determine their normal values. Concurrent perfusion manometry MII were performed in 42 healthy volunteers. Ten, 5‐mL liquid (saline) boluses then, 10 × low viscous tested each subject right‐lateral position. Normal values for presence time...
SUMMARY Background Frequent belching is a common symptom in patients with functional dyspepsia reported incidence up to 80%. We hypothesized that possibly have higher frequency of than healthy subjects secondary frequent air swallowing. Aim To assess swallowing, belching, acid and non‐acid reflux patterns dyspepsia. Methods Combined 24‐h oesophageal impedance pH monitoring was performed 10 controls. Analysis the impedance‐pH signals included swallows, reflux. Results The swallows were...