A5025936343- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Esophageal and GI Pathology
- Dysphagia Assessment and Management
- Respiratory and Cough-Related Research
- Helicobacter pylori-related gastroenterology studies
- Obstructive Sleep Apnea Research
- Organ Transplantation Techniques and Outcomes
- Tracheal and airway disorders
- Frailty in Older Adults
- Liver Diseases and Immunity
- Immune Response and Inflammation
- Gallbladder and Bile Duct Disorders
- Immunotherapy and Immune Responses
- Vascular anomalies and interventions
- Mobile Health and mHealth Applications
- Dialysis and Renal Disease Management
- Pediatric health and respiratory diseases
- T-cell and B-cell Immunology
- Cytomegalovirus and herpesvirus research
- Medical History and Research
- Social Media in Health Education
- Anesthesia and Neurotoxicity Research
- Renal Transplantation Outcomes and Treatments
- Liver Disease Diagnosis and Treatment
Amsterdam University Medical Centers
2020-2023
University of Amsterdam
2020-2023
Community Link
2021
Brigham and Women's Hospital
2015-2017
Harvard University
2015-2017
University of Groningen
2017
University Medical Center Groningen
2015
Abstract CD4 + CD25 Foxp3 Tregs have been shown to play a central role in immune homeostasis while preventing from fatal inflammatory responses, Th17 cells traditionally recognized as pro-inflammatory mediators implicated myriad of diseases. Studies the potential convert into and Tregs. Increasing evidence pointed out key molecule during this transdifferentiation process, however molecules that allow such development remain unknown. Here, we investigated impact NAD on fate in-depth,...
The aim of this study was to investigate the effect spontaneous sleep positions on occurrence nocturnal gastroesophageal reflux.In patients referred for ambulatory pH-impedance reflux monitoring, concurrent position measured using a measurement device (measuring left, right, supine, and prone positions).Fifty-seven were included. We observed significantly shorter acid exposure time in left (median 0.0%, P25-P75, 0.0%-3.0%), compared with right lateral 1.2%, 0.0%-7.5%, P = 0.022) supine 0.6%,...
Although inability to belch has previously been linked dysfunction of the upper esophageal sphincter (UES), its underlying pathogenesis remains unclear. Our aim was study mechanisms and effect UES botulinum toxin (botox) injections in these patients.We prospectively enrolled consecutive patients with symptoms belch. Patients underwent stationary high-resolution impedance manometry (HRIM) provocation ambulatory 24-h pH-impedance monitoring before 3 months after botox injection.Eight (four...
Objective There is no evidence-based treatment for persistent dysphagia after laparoscopic fundoplication. The aim of this study was to evaluate the effect pneumatic dilation on Design We performed a multicentre, single-blind, randomised sham-controlled trial patients with (>3 months) Patients an Eckardt symptom score ≥4 were randomly assigned (PD) using 35 mm balloon or sham dilation. Primary outcome success, defined as <4 and minimal reduction 2 points in 30 days. Secondary outcomes...
Background Accurate information on the natural course of giant paraesophageal hernia is scarce, challenging therapeutic decisions whether or not to operate. Objective We aimed investigate long‐term outcomes, including hernia‐related deaths and complications (e.g. volvulus, gastrointestinal bleeding, strangulation) patients with that were conservatively managed, determine factors associated clinical outcome. Methods retrospectively analysed charts diagnosed between January 1990 August 2019,...
Immunosuppression in elderly recipients has been underappreciated clinical trials. Here, we assessed age-specific effects of the calcineurin inhibitor tacrolimus (TAC) a murine transplant model and its relevance on human T cells. Old recipient mice exhibited prolonged skin graft survival compared with young animals after TAC administration. More important, half dose was sufficient old to achieve comparable systemic trough levels. administration able reduce proinflammatory interferon-γ...
INTRODUCTION: This study aimed to assess the diagnostic yield of routine esophageal biopsies in patients with refractory reflux symptoms. METHODS: We prospectively enrolled consecutive referred for upper endoscopy and collected histological, clinical, endoscopic data. RESULTS: Of 301 included patients, 14 (4.7%) met clinicopathological definition eosinophilic esophagitis. Presence dysphagia, food bolus impaction, atopic background, typical features were factors strongest association accuracy...
Abstract Background and study aims Epiphrenic diverticula are rare mainly occur in patients with underlying esophageal motility disorders. The current standard treatment is surgical diverticulectomy often combined by myotomy associated significant adverse event (AE) rates. aim of this was to examine the efficacy safety peroral endoscopic reducing symptoms diverticula. Patients methods We performed a retrospective cohort including an diverticulum who underwent POEM between October 2014...
Summary Background Although nighttime reflux symptoms are common, the presence of nocturnal is seldom confirmed with a standard 24 hours pH study. Aim To study patients supine using prolonged wireless monitoring. Methods In this retrospective study, typical acid were studied 96‐h Patients compared to those without. Night‐to‐night variability and diagnostic accuracy 24‐, 48‐ 72‐hours studies 96‐hours “gold standard” evaluated. Results Of 105 included (61.9% females; mean age 46.8 ± 14.4...
The aim of the study was to evaluate effect an electronic positional therapy wearable device on nocturnal gastroesophageal reflux measured by pH-impedance monitoring.We performed a single-center, prospective, interventional in 30 patients with symptoms and esophageal acid exposure time (AET) ≥1.5% off acid-suppressive medication ambulatory monitoring. Patients were treated for 2 weeks. vibrates right lateral decubitus position so it conditions avoid that sleep position. After weeks...
Abstract Background Gastroesophageal reflux disease (GERD) is one of the most prevalent gastrointestinal diseases in western world. Lifestyle modifications and proton pump inhibitors (PPIs) form basis management GERD. A subset patients seeks for (natural) alternative therapies besides PPIs. benesco™ an over‐the‐counter nutrition based on quercetin which has a presumed positive effect esophageal barrier function. Therefore we aim to assess symptoms. Methods We performed double‐blind...
Renske A B Oude Nijhuis, Thijs Kuipers, Jac M Oors, Thomas V K Herregods, Boudewijn F Kessing, Jeroen Schuitenmaker, Andreas J P Smout, and Albert Bredenoord. Neurogastroenterol Motil -0001;0:. https://doi.org/10.5056/jnm23014
Introduction: Older donor organs are increasingly utilized to close the gap between demand and supply. We submit that aging-associated kinetics of damage associated molecular patterns (DAMPs) such as mitochondrial DNA (mtDNA) drive augmented susceptibility older ischemia reperfusion injury (IRI). Methods: Old young mice underwent bilateral clamping renal pedicles (ischemic time, 22 min at controlled body temp.) representing an established model IRI. MtDNA levels were tested by qPCR;...