A5007079238- Gastrointestinal motility and disorders
- Mental Health Research Topics
- Health, psychology, and well-being
- Gut microbiota and health
- Perfectionism, Procrastination, Anxiety Studies
- Gastroesophageal reflux and treatments
- Endometriosis Research and Treatment
- Diet and metabolism studies
- Eating Disorders and Behaviors
- Pathogenesis and Treatment of Hiccups
- Sleep and related disorders
- Congenital gastrointestinal and neural anomalies
- Child Nutrition and Feeding Issues
- Schizophrenia research and treatment
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Infant Health and Development
- Pelvic floor disorders treatments
- Mental Health and Psychiatry
- Complementary and Alternative Medicine Studies
- Cognitive and psychological constructs research
- Music Therapy and Health
- Clostridium difficile and Clostridium perfringens research
- Intestinal and Peritoneal Adhesions
- Connective tissue disorders research
- Behavioral Health and Interventions
Maastricht University
2016-2025
Radboud University Nijmegen
2023
Catharina Ziekenhuis
2023
Maastricht University Medical Centre
2019-2022
Geneeskundige en Gezondheidsdienst
2021
University Medical Center
2016-2019
<h3>Background and aims</h3> Proton pump inhibitors (PPIs) are among the top 10 most widely used drugs in world. PPI use has been associated with an increased risk of enteric infections, notably <i>Clostridium difficile.</i> The gut microbiome plays important role by resisting or promoting colonisation pathogens. In this study, we investigated influence on microbiome. <h3>Methods</h3> composition 1815 individuals, spanning three cohorts, was assessed tag sequencing 16S rRNA gene. difference...
To gain insight into the complex microbiome-gut-brain axis in irritable bowel syndrome (IBS), several modalities of biological and clinical data must be combined. We aimed to identify profiles fecal microbiota metabolites associated with IBS delineate specific phenotypes that represent potential pathophysiological mechanisms. Fecal were measured using proton nuclear magnetic resonance (1H-NMR) spectroscopy gut microbiome shotgun metagenomic sequencing (MGS) a combined dataset 142 patients...
Background & AimsIrritable bowel syndrome (IBS) is associated with substantial costs to society. Extensive data on direct (health care consumption) and indirect (health-related productivity loss) are lacking. Hence, we examined the socioeconomic of IBS assessed which patient characteristics higher costs.MethodsCross-sectional from 3 Rome-defined Dutch cohorts (n = 419) were collected. Bootstrapped mean evaluated per using validated questionnaires (ie, medical cost questionnaire...
Abstract Background The Rome criteria for irritable bowel syndrome ( IBS ) have been revised and are expected to apply only the subset of III subjects with abdominal pain as predominant symptom, occurring at least once a week. aim this study was determine percentage that fulfills IV evaluate differences between ‐positive IV‐negative subjects. Methods Four hundred four completed 14‐day end‐of‐day symptom diary, Gastrointestinal Symptom Rating Scale GSRS ), Hospital Anxiety Depression Scale,...
Abstract Background Self‐rating scales are frequently used to screen for anxiety and depression in patients with irritable bowel syndrome (IBS). Different cutoff values recommended literature, guidelines have suggested the use of other screening instruments over time. The aim this study was assess correlation between most commonly psychological IBS compare custom scores these instruments. Methods Irritable ( n = 192) completed several questionnaires including Hospital Anxiety Depression...
Abstract Background Retrospective questionnaires are frequently used for symptom assessment in irritable bowel syndrome ( IBS ) patients, but influenced by recall bias and circumstantial psychological factors. These limitations may be overcome random, repeated, momentary during the day, using electronic Experience Sampling Methodology ESM ). Therefore, we compared to retrospective paper patients. Methods Twenty‐six patients (Rome III) were included, of which 16 diagnosed with panic disorder...
Abstract Background Irritable bowel syndrome (IBS) is a brain‐gut disorder, of which the natural course varies between patients and difficult to predict. This study aimed evaluate symptom evolution over 5‐year follow‐up period identify baseline predictors for severity quality life (QoL) at follow‐up. Methods Maastricht IBS cohort participants completed questionnaires upon inclusion regarding demographics lifestyle, gastrointestinal (GI) symptoms, anxiety depression, QoL. The same...
Abstract Background End‐of‐day questionnaires, which are considered the gold standard for assessing abdominal pain and other gastrointestinal ( GI ) symptoms in irritable bowel syndrome IBS ), influenced by recall ecological bias. The experience sampling method ESM is characterized random repeated assessments natural state environment of a subject, herewith overcomes these limitations. This report describes development patient‐reported outcome measure PROM based on principle, taking into...
Stool consistency has been associated with fecal microbial composition. often varies over time, in subjects and without gastrointestinal disorders, raising the question whether variability composition should be considered microbiota studies. We evaluated within-subject day-to-day stool association irritable bowel syndrome (IBS) healthy subjects, seven days.Twelve IBS patients 12 collected samples during consecutive days. was determined by patient-reported Bristol Scale (BSS) dry weight...
Introduction: The world population is ageing, resulting in increased prevalence of age-related comorbidities and healthcare costs. Limited data are available on intestinal health elderly populations. Structural functional changes, including altered visceroperception, may lead to bowel habits abdominal symptoms healthy individuals irritable syndrome (IBS) patients. Our aim was explore changes gastrointestinal underlying mechanisms. Methods: In total, 780 subjects (IBS patients n = 463, 317)...
INTRODUCTION: Sleep quality may affect symptom experience in irritable bowel syndrome (IBS). Our aim was to investigate the relationship between sleep and gastrointestinal (GI) symptoms using actigraphy sampling method. METHODS: Patients with IBS were recruited from a tertiary Neurogastroenterology clinic community. GI mood recorded on smartphone application, 10 times per day, over 7 consecutive days. Subjective every morning reflect night before. Objective measures of estimated wrist-worn...
Real-time assessment of gastrointestinal (GI) symptoms in irritable bowel syndrome (IBS) using the experience sampling method (ESM) is suggested as a more appropriate approach than currently used end-of-day or end-of-week reports. This psychometric evaluation study assesses validity and reliability previously developed ESM-based patient-reported outcome measure (PROM) for real-time GI symptom IBS.
INTRODUCTION: Gastrointestinal symptoms in irritable bowel syndrome (IBS) have been correlated with psychological factors using retrospective symptom assessment. However, real-time assessment might reveal the interplay between abdominal and affective more reliably a longitudinal perspective. The aim was to evaluate association stress pain, Experience Sampling Method (ESM) as real-time, repeated measurement method. METHODS: Thirty-seven patients IBS (26 women; mean age 36.7 years) 36 healthy...
Abstract Background Patient‐reported outcome measures (PROMs) are used to assess symptoms in patients with functional dyspepsia (FD). Current end‐of‐day questionnaires have several limitations including sensitivity recall and ecological bias. The experience sampling method (ESM) is characterized by random repeated assessments across momentary states daily life therefore less sensitive these limitations. This study describes the development of a novel PROM based on ESM technology. Methods An...
Abstract Background Confirming treatment response in clinical trials for irritable bowel syndrome (IBS) is challenging, due to the lack of biomarkers and limitations currently available symptom assessment tools. The Experience Sampling Method (ESM) might overcome these by collecting digital assessments randomly repeatedly during daily life. This study evaluated differences change abdominal pain between real‐time (ie, ESM) retrospective (ie , Gastrointestinal Symptom Rating Scale [GSRS] an...
Irritable bowel syndrome (IBS) has a high comorbidity with mental disorders. The present paper aims to visualise the interplay between IBS and affect (anxiety mood) in daily life. Furthermore, this may be different depending on risk factors such as childhood trauma. Using momentary assessment (Experience Sampling Method), data of 24 individuals diagnosed both panic disorder were analysed (15 non-trauma 9 low-trauma-score patients). Networks constructed, based multilevel time-lagged linear...
End-of-day symptom diaries are recommended by drug regulatory authorities to assess treatment response in patients with irritable bowel syndrome. We developed a smartphone app measure response.Because the employment of an syndrome is relatively new, we aimed explore patients' adherence diary use and characteristics associated adherence.A was serve as diary. Patients (based on Rome IV criteria) were instructed fill out end-of-day questionnaires during 8-week treatment. Additional online...
INTRODUCTION: Irritable bowel syndrome (IBS) has a major impact on emotional, social, and professional life. This study aimed to evaluate general life satisfaction, subjective measure of well-being, in IBS patients, determine which factors are associated with higher satisfaction. METHODS: patients (n = 195, mean age 51.4 ± 16.5 years, 73.8% female) recruited from primary secondary/tertiary care completed questionnaires regarding gastrointestinal symptoms, quality life, psychological factors,...
Momentary ecological assessment indicated alleviated abdominal pain in escitalopram treatment of irritable bowel syndrome (IBS) with comorbid panic disorder. Hitherto, little is known about symptom formation, i.e., how psychological impact physical symptoms, and vice versa, the effect SSRI-treatment on formation.To investigate somatic symptoms co-vary over time IBS patients disorder they are affected by treatment.Experience sampling data from 14 were obtained a single-centre, double-blind,...
Abstract Background Due to important biases, conventional end‐of‐day and end‐of‐week assessment methods of gastrointestinal symptoms in functional dyspepsia (FD) are considered suboptimal. Real‐time symptom based on the experience sampling method (ESM) could be a more accurate measurement method. This study aimed evaluate validity reliability an ESM‐based patient‐reported outcome measure (PROM) for FD. Methods Thirty‐five patients with FD (25 female, mean age 44.7 years) completed PROM (a...