A5052028481- Physics of Superconductivity and Magnetism
- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Advanced MRI Techniques and Applications
- Quantum and electron transport phenomena
- Superconducting and THz Device Technology
- Neutrino Physics Research
- Quantum Chromodynamics and Particle Interactions
- Superconductivity in MgB2 and Alloys
- Theoretical and Computational Physics
- Magnetic Properties and Applications
- Botulinum Toxin and Related Neurological Disorders
- Magnetic properties of thin films
- Semiconductor materials and devices
- Pain Mechanisms and Treatments
- Peripheral Nerve Disorders
- Advanced Neuroimaging Techniques and Applications
- Particle Detector Development and Performance
- MRI in cancer diagnosis
- Dark Matter and Cosmic Phenomena
- Magnetic Properties of Alloys
- Nuclear physics research studies
- Advanced NMR Techniques and Applications
- Magnetic and transport properties of perovskites and related materials
- Atomic and Subatomic Physics Research
Fermi National Accelerator Laboratory
2010-2024
University Hospital Heidelberg
2017-2021
Heidelberg University
2017-2021
German Center for Diabetes Research
2019
Brandenburg University of Technology Cottbus-Senftenberg
2003-2007
Ruhr University Bochum
1982-2002
Kiel University
1998
University of Oxford
1993-1996
Victoria Hospital
1979
Western University
1979
<h3>Importance</h3> Lowering serum cholesterol levels is a well-established treatment for dyslipidemia in patients with type 2 diabetes (T2D). However, nerve lesions T2D increase lower levels, suggesting that lowering associated diabetic polyneuropathy (DPN) T2D. <h3>Objective</h3> To investigate whether there an association between and peripheral without DPN. <h3>Design, Setting, Participants</h3> This single-center, cross-sectional, prospective cohort study was performed from June 1, 2015,...
Clinical studies have suggested that changes in peripheral nerve microcirculation may contribute to damage diabetic polyneuropathy (DN). High-sensitivity troponin T (hsTNT) assays been recently shown provide predictive values for both cardiac and microangiopathy type 2 diabetes (T2D). This study investigated the association of sciatic structural 3 Tesla (3T) magnetic resonance neurography (MRN) with hsTNT N-terminal pro-brain natriuretic peptide serum levels patients T2D. MRN at 3T was...
Nerve damage in diabetic neuropathy (DN) is assumed to begin the distal legs with a subsequent progression hands and arms at later stages. In contrast, recent studies have found that lower limb nerve lesions DN predominate proximal sciatic that, upper limb, functions can be impaired early stages of DN.In this prospective, single-center cross-sectional study, participants underwent diffusion-weighted 3 Tesla magnetic resonance neurography order calculate nerve's fractional anisotropy (FA),...
Background The pathophysiologic mechanisms underlying painful symptoms in diabetic polyneuropathy (DPN) are poorly understood. They may be associated with MRI characteristics, which have not yet been investigated. Purpose To investigate correlations between nerve structure, load and spatial distribution of lesions, pain patients DPN. Materials Methods In this prospective single-center cross-sectional study, participants type 1 or 2 diabetes volunteered June 2015 March 2018. Participants...
Abstract Glioblastoma multiforme alters healthy tissue vasculature by inducing angiogenesis and vascular remodeling. To fully comprehend the structural functional properties of resulting network, it needs to be studied collectively considering both geometric topological properties. Utilizing Single Plane Illumination Microscopy (SPIM), detailed capillary structure in entire tumor-bearing mouse brains could resolved three dimensions. At scale smallest capillaries, systems bulk U87-...
Objectives To apply the MB (multiband) excitation and blipped-CAIPI (blipped-controlled aliasing in parallel imaging) techniques a spin gradient-echo (SAGE) EPI sequence to improve slice coverage for vessel architecture imaging (VAI). Materials methods Both with in-plane were incorporated into (GE)/spin-echo (SE) simultaneous tracking of dynamic MR signal changes both GE SE contrasts after injection contrast agent. singleband (SB) compared using 20-channel head coil at 3 Tesla,...
Diffuse tumor infiltration into the adjacent parenchyma is an effective dissemination mechanism of brain tumors. We have previously developed correlated high field magnetic resonance imaging and ultramicroscopy (MR-UM) to study neonangiogenesis in a glioma model. In present we used MR-UM investigate neoangiogenesis translational approach. compare patterns four models human disease: whereas U87MG model resembles metastases with encapsulated growth extensive neoangiogenesis, S24 experimental...
Diabetic neuropathy (DPN) is one of the most severe and yet poorly understood complications diabetes mellitus. In vivo imaging dorsal root ganglia (DRG), a key structure for understanding DPN, has been restricted to animal studies. These have shown correlation decreased DRG volume with neuropathic symptom severity. Our objective was investigate correlations morphology signal characteristics at 3 Tesla (3T) magnetic resonance neurography (MRN) clinical serological data in diabetic patients...
A hysteretic transition to a high-injection-current nonequilibrium state in metallic contacts between silver and high-purity single-crystal tantalum was recently observed by the author H. Lerchner. Oscillations of conductance with bias this are interpreted as geometrical resonances excess current caused bias-driven variation superconductor--normal-metal phase-boundary position. Quantitative numerical results obtained from an extension one-dimensional Blonder-Tinkham-Klapwijk...
Abstract Well-developed phonon-structures are observed on Ta/Ta-Oxid/Ag and Nb/Nb-Oxid/Ag tunneling junctions, if the conditions of oxidation suitably choosen. These structures analyzed ac-cording to McMillan's numerical program results discussed. From nonlinear current-voltage characteristics in normal state, informations obtained electronic structure semiconducting oxid presenting barrier. Impurity concentration leading a nonideal semiconductor gap oxid, seems be largely reduced is...
The Peroxiredoxin 1 (PRDX1) gene maps to chromosome arm 1p and is hemizygously deleted epigenetically silenced in isocitrate dehydrogenase or 2 (IDH)-mutant 1p/19q-codeleted oligodendroglial tumors. In contrast, IDH-wildtype astrocytic gliomas including glioblastomas mostly lack epigenetic silencing express PRDX1 protein. our study, we investigated how contributes the infiltrative growth of gliomas. Focusing on p38α-dependent pathways, analyzed clinical data from 133 patients NOA-04 trial...
Three-dimensional assessment of optically cleared, entire organs and organisms has recently become possible by tissue clearing selective plane illumination microscopy ("ultramicroscopy"). Resulting datasets can be highly complex, encompass over a thousand images with millions objects data several gigabytes per acquisition. This constitutes major challenge for quantitative analysis. We have developed post-processing tools to quantify microvessels their distribution in three-dimensional from...
Abstract Die Temperaturabhängigkeit der spontanen Magnetisierung von Nickel auf Silikagel mit Korngrößen um 35 Å wird aus Messungen Anfangssuszeptibilität in kleinen Feldern zwischen 77 und 600 °K bestimmt vorliegenden theoretischen experimentellen Ergebnissen verglichen. hohen bis 20 kOe bei drei Temperaturen werden mitgeteilt es untersucht, inwieweit solchen Rückschlüsse die spontane gezogen können.
We correlated the results of biopsy a muscle nerve, sensory and tibialis anterior with electrophysiologic studies in 13 patients sensorimotor polyneuropathy 6 normal findings. There were significant correlations between teased fiber changes conduction abnormalities both nerves nerves. The density large myelinated fibers lateral fascicle deep peroneal (LFDP) nerve significantly motor unit estimate compound action potential amplitude extensor digitorum brevis (EDB) muscle. Other...
Conductance-voltage characteristics measured on Ta/Ta2O5/Ag tunneling junctions are strongly asymmetric. A similar result is known for Al/Al2O3/Pb junctions. In the case results fully consistent with two-band model κ (E) dependence in oxide barrier. value of 2 V obtained ’’contact potential’’ describing barrier asymmetry. This well understood basis electrochemical data Ta2O5 surface films Ta. The same mechanism suggested to apply
Low temperature specific heat measurements on a copper +0.7 at% cobalt alloy isothermally aged at 400 degrees C indicate the existence of linear magnetic cluster contribution as predicted by theory superparamagnetism. Quantitative analysis making use particle size data from gives mean anisotropy energy order 106 erg cm-3.
Two different ways of preparing the oxide barrier in tunneling junctions on Ta and Nb yield conductance-voltage characteristics. While a ’’dirty’’ preparation method with atmospheric air as an oxidation medium leads to strongly polarity-dependent but temperature-independent characteristics, we find rather symmetric voltage-dependent temperature-dependent (hence ’’low-quality’’) characteristics when is performed pure oxygen dc plasma discharge. High or low quality former latter case,...
The concept of uniform bulk magnetization in superparamagnetic particles is examined critically. By a straightforward idealization the conditions met actual samples, it shown that this related to fundamental problem physical statistics magnetic first-order phase transitions. Thus, fact applicable experimental data on superparamagnets has far-reaching consequences with respect nature transition at zero field.